concept

MSR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MSR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

151Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

MSR1 is a concept in neurodegeneration research. Key relationships include: biomarker for, activates, expressed in. Associated with ALS, Als, Alzheimer. Connected to 94 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	MSR1
Key Genes/Proteins	ALZHEIMER, AND, App, CANCER, CCR9, CD14
Related Diseases	Als, ALS, Alzheimer, Alzheimer's Disease, ALZHEIMER'S DISEASE
Related Pathways	Cholesterol

Pathway Diagram

graph TD
    MSR1["MSR1"]
    MSR1 -->|"regulates"| PHAGOCYTOSIS["PHAGOCYTOSIS"]
    MSR1 -->|"activates"| Dementia["Dementia"]
    MSR1 -->|"activates"| Als["Als"]
    MSR1 -->|"activates"| Alzheimer["Alzheimer"]
    MSR1 -->|"activates"| Parkinson["Parkinson"]
    MSR1 -->|"activates"| Ms["Ms"]
    MSR1 -.biomarker for.-> Inflammation["Inflammation"]
    MSR1 -.biomarker for.-> Atherosclerosis["Atherosclerosis"]
    HSPA1A["HSPA1A"] -->|"activates"| MSR1
    NR4A2["NR4A2"] -.biomarker for.-> MSR1
    CXCL2["CXCL2"] -.biomarker for.-> MSR1
    CSF2["CSF2"] -.biomarker for.-> MSR1
    IL1A["IL1A"] -.biomarker for.-> MSR1
    HTR3C["HTR3C"] -.biomarker for.-> MSR1
    IL13RA1["IL13RA1"] -.biomarker for.-> MSR1
    ICAM1["ICAM1"] -->|"activates"| MSR1
    TREM2["TREM2"] -->|"expressed in"| MSR1
    TLR2["TLR2"] -->|"activates"| MSR1

Outgoing (91)

Target	Relation	Type	Str
Dementia with Lewy Bodies	upregulates	disease	0.95
Myelin Phagocytosis	mediates	process	0.90
Alzheimer's Disease	upregulates	disease	0.90
Dementia With Lewy Bodies	upregulates	disease	0.90
Parkinson's Disease Dementia	upregulates	disease	0.90
Microglia	upregulates	cell_type	0.90
Phagocytosis	mediates	process	0.90
Coronary Artery Disease	biomarker_for	disease	0.90
Microglial Phagocytosis	mediates	process	0.85
PARKINSON'S DISEASE DEMENTIA	upregulates	disease	0.85
ALZHEIMER'S DISEASE	upregulates	disease	0.85
DEMENTIA	upregulates	disease	0.85
PHAGOCYTOSIS	regulates	phenotype	0.72
Fibrosis	biomarker_for	disease	0.65
ALS	biomarker_for	disease	0.65
ALS	activates	disease	0.65
Inflammation	biomarker_for	disease	0.65
Ms	expressed_in	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Als	biomarker_for	disease	0.65
Atherosclerosis	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Parkinson	activates	disease	0.65
Ms	activates	disease	0.65
Dementia	activates	disease	0.65
Als	activates	disease	0.65
Alzheimer	activates	disease	0.65
MICROGLIA	expressed_in	cell_type	0.64
MRC1	expressed_in	gene	0.60
PPARG	expressed_in	gene	0.60
P53 Pathway	expressed_in	pathway	0.60
neurodegeneration	associated_with	disease	0.60
STAT3	biomarker_for	gene	0.60
MMP9	biomarker_for	gene	0.60
JAK1	biomarker_for	gene	0.60
HTR3C	biomarker_for	gene	0.60
NTS	biomarker_for	gene	0.60
IL1A	biomarker_for	gene	0.60
LDLR	biomarker_for	gene	0.60
Cholesterol	biomarker_for	pathway	0.60
Immune Response	biomarker_for	pathway	0.60
JUN	activates	gene	0.60
Nf-Κb	expressed_in	pathway	0.60
Oxidative Phosphorylation	expressed_in	pathway	0.60
MBP	associated_with	gene	0.60
HSPA1A	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
MYELIN	activates	gene	0.60
AND	expressed_in	gene	0.60

Incoming (60)

Source	Relation	Type	Str
PARKINSON'S DISEASE	upregulates	disease	0.85
Myelin	upregulates	compound	0.80
TLR2	activates	gene	0.60
NFKBIA	activates	gene	0.60
MRC1	expressed_in	gene	0.60
IL1B	expressed_in	gene	0.60
P53	expressed_in	gene	0.60
ITGAM	activates	gene	0.60
TNF	expressed_in	gene	0.60
NF-ΚB	expressed_in	gene	0.60
CXCL2	expressed_in	gene	0.60
CD14	activates	gene	0.60
CANCER	activates	gene	0.60
PPARG	expressed_in	gene	0.60
TNF-Α	expressed_in	gene	0.60
LDLR	biomarker_for	gene	0.60
ICAM1	activates	gene	0.60
GENES	biomarker_for	gene	0.60
MMP9	biomarker_for	gene	0.60
NTS	biomarker_for	gene	0.60
INFLAMMATION	biomarker_for	gene	0.60
STAT3	biomarker_for	gene	0.60
JAK1	biomarker_for	gene	0.60
TREM2	expressed_in	gene	0.60
HSPA1A	activates	gene	0.60
MBP	associated_with	gene	0.60
NR4A2	biomarker_for	gene	0.60
CXCL2	biomarker_for	gene	0.60
CSF2	biomarker_for	gene	0.60
IL1A	biomarker_for	gene	0.60
HTR3C	biomarker_for	gene	0.60
IL13RA1	biomarker_for	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
MICROGLIA	activates	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
PLP1	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
TNFRSF19	biomarker_for	gene	0.60
RNA	biomarker_for	gene	0.60
AND	biomarker_for	gene	0.60
CCR9	biomarker_for	gene	0.60
GENES	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
PARKINSON	activates	gene	0.60
MYELIN	activates	gene	0.60
DEMENTIA	activates	gene	0.60
MOBP	activates	gene	0.60
RNA	activates	gene	0.60
AND	activates	gene	0.60
GENES	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MSR1 in their description or question text

No additional research found