protein

WTAP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WTAP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

79Connections

0Hypotheses

0Analyses

50Outgoing

27Incoming

0Experiments

0Debates

Summary

Page for WTAP Protein (Wilms' Tumor 1-Associated Protein)

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🔬 Protein Info

Gene Symbol	WTAP
Aliases	Wilms' Tumor 1-Associated Protein
Function	WTAP (Wilms' Tumor 1-Associated Protein) is a 399-amino acid nuclear protein that serves as a regulatory subunit of the N6-methyladenosine (m6A) methyltransferase complex.
Subcellular Localization	</strong> Nucleus (nuclear speckles)</div> <div class="infobox-row"><strong>Pr
Molecular Weight	44.2 kDa
Amino Acids	399 aa
Pathways	Wnt, Tgf-Β, Ferroptosis
GeneCards	WTAP
Human Protein Atlas	WTAP
Associated Diseases	Als, Cancer
Interactions	ACSL5, BAMBI, CSF2, FERROPTOSIS, HDAC5, METTL3
KG Connections	79 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

WTAP Protein (Wilms' Tumor 1-Associated Protein)

protein · 750 words

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Pathway Diagram

graph TD
    WTAP["WTAP"]
    Cancer{"Cancer"}
    WTAP -->|"therapeutic target"| Cancer
    Als{"Als"}
    WTAP -->|"therapeutic target"| Als
    Ms{"Ms"}
    WTAP -->|"therapeutic target"| Ms
    Carcinoma{"Carcinoma"}
    WTAP -->|"inhibits"| Carcinoma
    WTAP -->|"inhibits"| Ms
    WTAP -->|"associated with"| Als
    WTAP -->|"associated with"| Cancer
    WTAP -->|"activates"| Carcinoma
    ALS{"ALS"}
    WTAP -->|"contributes to"| ALS
    WTAP -->|"contributes to"| Cancer
    PPARGC1A["PPARGC1A"]
    WTAP -->|"inhibits"| PPARGC1A
    HNRNPA2B1["HNRNPA2B1"]
    WTAP -->|"therapeutic target"| HNRNPA2B1
    KDM5A["KDM5A"]
    KDM5A -->|"upregulates"| WTAP
    HNRNPA2B1 -->|"associated with"| WTAP
    IGF2BP1["IGF2BP1"]
    IGF2BP1 -->|"associated with"| WTAP
    METTL3["METTL3"]
    METTL3 -->|"associated with"| WTAP
    ACSL5["ACSL5"]
    ACSL5 -->|"activates"| WTAP
    BAMBI["BAMBI"]
    BAMBI -->|"activates"| WTAP
    PPARGC1A -->|"associated with"| WTAP
    GENES["GENES"]
    GENES -->|"contributes to"| WTAP
    IGF2BP1 -->|"contributes to"| WTAP
    CANCER["CANCER"]
    CANCER -->|"contributes to"| WTAP
    ROS["ROS"]
    ROS -->|"inhibits"| WTAP
    ACSL5 -->|"inhibits"| WTAP
    style WTAP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (52)

Target	Relation	Type	Str
N6-Methyladenosine	regulates	compound	0.95
m6A modification	mediates	process	0.85
PPARGC1A	downregulates	gene	0.85
m6A Modification	regulates	process	0.85
Ms	inhibits	disease	0.65
Carcinoma	activates	disease	0.65
Carcinoma	inhibits	disease	0.65
Als	expressed_in	disease	0.65
ALS	contributes_to	disease	0.65
Als	activates	disease	0.65
Cancer	associated_with	disease	0.65
Cancer	activates	disease	0.65
Als	associated_with	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
PPARGC1A	inhibits	gene	0.64
CSF2	activates	gene	0.60
Rb	associated_with	protein	0.60
Stat3	therapeutic_target	protein	0.60
Ras	associated_with	protein	0.60
Igf	therapeutic_target	protein	0.60
FERROPTOSIS	inhibits	gene	0.60
ROS	inhibits	gene	0.60
HNRNPA2B1	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
IGF2BP1	therapeutic_target	gene	0.60
METTL3	associated_with	gene	0.60
YTHDF1	contributes_to	gene	0.60
WNT	inhibits	gene	0.60
RNA	therapeutic_target	gene	0.60
METTL3	inhibits	gene	0.60
RORA	expressed_in	gene	0.60
TGM2	expressed_in	gene	0.60
PIK3R1	expressed_in	gene	0.60
YTHDF2	activates	gene	0.60
YTHDF2	associated_with	gene	0.60
ACSL5	inhibits	gene	0.60
BAMBI	inhibits	gene	0.60
PPARGC1A	associated_with	gene	0.60
Wnt	inhibits	pathway	0.60
Tgf-Β	inhibits	pathway	0.60
Ferroptosis	inhibits	pathway	0.60
Ferroptosis	activates	pathway	0.60
HNRNPA2B1	contributes_to	gene	0.60
Wnt	activates	pathway	0.60
IGF2BP1	contributes_to	gene	0.60
CANCER	contributes_to	gene	0.60
RNA	contributes_to	gene	0.60
ALKBH5	associated_with	gene	0.60

Incoming (27)

Source	Relation	Type	Str
KDM5A	upregulates	gene	0.80
TNF	activates	gene	0.60
METTL3	associated_with	gene	0.60
ACSL5	activates	gene	0.60
BAMBI	activates	gene	0.60
PPARGC1A	associated_with	gene	0.60
ROS	inhibits	gene	0.60
ACSL5	inhibits	gene	0.60
BAMBI	inhibits	gene	0.60
HDAC5	activates	gene	0.60
FERROPTOSIS	inhibits	gene	0.60
IGF2BP1	associated_with	gene	0.60
HNRNPA2B1	associated_with	gene	0.60
PPARGC1A	inhibits	gene	0.60
GENES	contributes_to	gene	0.60
CANCER	contributes_to	gene	0.60
WNT	inhibits	gene	0.60
NR1D2	expressed_in	gene	0.60
CKAP4	expressed_in	gene	0.60
GAIN	expressed_in	gene	0.60
LAMP3	expressed_in	gene	0.60
ABCG1	expressed_in	gene	0.60
METTL14	expressed_in	gene	0.60
FTO	associated_with	gene	0.60
RNA	therapeutic_target	gene	0.60
HNRNPA2B1	therapeutic_target	gene	0.60
ALKBH5	associated_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning WTAP in their description or question text

No additional research found