gene

PDGFB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PDGFB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

88Connections

0Hypotheses

0Analyses

50Outgoing

23Incoming

0Experiments

0Debates

Summary

PDGFB is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, expressed in. Associated with ALS, Aging, Als. Connected to 46 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PDGFB
Full Name	Platelet Derived Growth Factor Subunit B
Chromosome	22q13
Function	PDGFB encodes the B chain of platelet-derived growth factor, which can form homodimers (PDGF-BB) or heterodimers (PDGF-AB) with the A chain.
Pathways	Inflammasome
UniProt ID	[P01127](https://www.uniprot.org/uniprot/P01127)
Ensembl ID	ENSG00000127314
OMIM	190040
GeneCards	PDGFB
Human Protein Atlas	PDGFB
Associated Diseases	Aging, Als, Basal Ganglia Calcifications, Fahr_disease, Ms
Interactions	App, CMPK2, GENES, Il-1, IL-1, JAM2
KG Connections	88 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PDGFB — Platelet Derived Growth Factor Subunit B

gene · 537 words

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Pathway Diagram

graph TD
    PDGFB["PDGFB"]
    Aging{"Aging"}
    PDGFB -->|"associated with"| Aging
    Ms{"Ms"}
    PDGFB -->|"associated with"| Ms
    Parkinson{"Parkinson"}
    PDGFB -->|"associated with"| Parkinson
    Als{"Als"}
    PDGFB -->|"associated with"| Als
    PDGFB -->|"regulates"| Ms
    PDGFB -->|"inhibits"| Ms
    Fibrosis{"Fibrosis"}
    PDGFB -->|"expressed in"| Fibrosis
    PDGFB -->|"expressed in"| Als
    ALS{"ALS"}
    PDGFB -->|"associated with"| ALS
    Fahr_disease{"Fahr_disease"}
    PDGFB -->|"causes"| Fahr_disease
    Blood_Brain_Barrier(["Blood-Brain Barrier"])
    PDGFB -->|"associated with"| Blood_Brain_Barrier
    PDGFRB["PDGFRB"]
    PDGFB -->|"associated with"| PDGFRB
    JUN["JUN"]
    JUN -->|"associated with"| PDGFB
    JAM2["JAM2"]
    JAM2 -->|"associated with"| PDGFB
    PDGFRB -->|"associated with"| PDGFB
    PDGFRB -->|"regulates"| PDGFB
    GENES["GENES"]
    GENES -->|"regulates"| PDGFB
    GENES -->|"inhibits"| PDGFB
    PDGFRB -->|"expressed in"| PDGFB
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
    MITOCHONDRIAL_DYSFUNCTION -->|"associated with"| PDGFB
    GENES -->|"associated with"| PDGFB
    XPR1["XPR1"]
    XPR1 -->|"associated with"| PDGFB
    SLC20A2["SLC20A2"]
    SLC20A2 -->|"associated with"| PDGFB
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"associated with"| PDGFB
    style PDGFB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (65)

Target	Relation	Type	Str
Primary Familial Brain Calcification	associated_with	disease	0.95
Primary Familial Brain Calcification	causes	disease	0.95
Basal Ganglia Calcifications	causes	disease	0.93
Fahr's Disease	risk_factor_for	disease	0.90
neurovascular unit	modulates	cell_type	0.80
Atherosclerosis	activates	disease	0.65
Als	activates	disease	0.65
Aging	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Als	associated_with	disease	0.65
Fibrosis	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Ms	inhibits	disease	0.65
Ms	regulates	disease	0.65
ALS	associated_with	disease	0.65
Fahr_disease	causes	disease	0.64
T Cell	activates	cell_type	0.60
Fibroblast	activates	cell_type	0.60
Macrophage	activates	cell_type	0.60
Il-1	activates	protein	0.60
App	activates	protein	0.60
Rb	associated_with	protein	0.60
TGFB3	expressed_in	gene	0.60
TGFB1	expressed_in	gene	0.60
TGFB2	expressed_in	gene	0.60
VEGFB	expressed_in	gene	0.60
CSF2	expressed_in	gene	0.60
Vegf	expressed_in	protein	0.60
Rb	expressed_in	protein	0.60
MERTK	activates	gene	0.60
TREM2	activates	gene	0.60
PARKINSON	associated_with	gene	0.60
MYORG	associated_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
CMPK2	associated_with	gene	0.60
Pdgf	associated_with	protein	0.60
PDGF	activates	gene	0.60
Inflammasome	activates	pathway	0.60
Neutrophil	activates	cell_type	0.60
Tgf-Β	expressed_in	pathway	0.60
SLC20A2	interacts_with	gene	0.60
XPR1	interacts_with	gene	0.60
BLM	expressed_in	gene	0.60
JAM2	associated_with	gene	0.60
JUN	associated_with	gene	0.60
PDGFRB	interacts_with	gene	0.60
GENES	associated_with	gene	0.60
XPR1	associated_with	gene	0.60
SLC20A2	associated_with	gene	0.60

Incoming (23)

Source	Relation	Type	Str
CMPK2	associated_with	gene	0.60
MYORG	associated_with	gene	0.60
IL-1	activates	gene	0.60
GENES	inhibits	gene	0.60
JUN	associated_with	gene	0.60
JAM2	associated_with	gene	0.60
PDGFRB	associated_with	gene	0.60
PDGFRB	expressed_in	gene	0.60
GENES	regulates	gene	0.60
XPR1	regulates	gene	0.60
SLC20A2	regulates	gene	0.60
PARKINSON	associated_with	gene	0.60
MYORG	interacts_with	gene	0.60
PDGFRB	regulates	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
CMPK2	interacts_with	gene	0.60
VEGFA	expressed_in	gene	0.60
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.60
GENES	associated_with	gene	0.60
XPR1	associated_with	gene	0.60
SLC20A2	associated_with	gene	0.60
PDGFRB	interacts_with	gene	0.50
JAM2	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PDGFB in their description or question text

No additional research found