Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HTRA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
HTRA1 is a gene implicated in neurodegeneration research. Key relationships include: contributes to, implicated in. Associated with Aging, Als, Dementia. Connected to 10 entities in the SciDEX knowledge graph.
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| Gene Symbol | HTRA1 |
| Full Name | HTRA1 serine peptidase 1 |
| Chromosome | 10q26.13 |
| Protein Family | HTRA serine protease family |
| Protein Type | Protease |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 53 kDa |
| Amino Acids | 480 aa |
| Exons | 6 |
| Pathways | TGF-β |
| UniProt ID | Q92743 |
| NCBI Gene ID | 5657 |
| Ensembl ID | ENSG00000166033 |
| OMIM | 607784 |
| GeneCards | HTRA1 |
| Human Protein Atlas | HTRA1 |
| Associated Diseases | neurodegeneration |
| Interactions | AND, APOE, GENETIC LOCI, Proteins, Ras, VEGFA |
| KG Connections | 33 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
HTRA1["HTRA1"]
Dementia{"Dementia"}
HTRA1 -->|"contributes to"| Dementia
Aging{"Aging"}
HTRA1 -->|"contributes to"| Aging
Als{"Als"}
HTRA1 -->|"contributes to"| Als
Stroke{"Stroke"}
HTRA1 -->|"contributes to"| Stroke
COL4A1["COL4A1"]
HTRA1 -->|"contributes to"| COL4A1
OVERVIEW["OVERVIEW"]
HTRA1 -->|"contributes to"| OVERVIEW
Notch(["Notch"])
HTRA1 -->|"contributes to"| Notch
neurodegeneration["neurodegeneration"]
HTRA1 -->|"implicated in"| neurodegeneration
NOTCH3["NOTCH3"]
NOTCH3 -->|"contributes to"| HTRA1
GENES["GENES"]
GENES -->|"contributes to"| HTRA1
style HTRA1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | interacts_with | disease | 0.65 |
| Aging | contributes_to | disease | 0.65 |
| Dementia | contributes_to | disease | 0.65 |
| Als | contributes_to | disease | 0.65 |
| Stroke | contributes_to | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| Dementia | expressed_in | disease | 0.65 |
| Stroke | expressed_in | disease | 0.65 |
| ALS | interacts_with | disease | 0.65 |
| GENETIC LOCI | interacts_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| NOTCH3 | contributes_to | gene | 0.60 |
| Notch | contributes_to | pathway | 0.60 |
| APOE | associated_with | gene | 0.60 |
| Ras | interacts_with | protein | 0.60 |
| COL4A1 | contributes_to | gene | 0.60 |
| OVERVIEW | contributes_to | gene | 0.60 |
| VEGFA | regulates | gene | 0.60 |
| VEGFA | activates | gene | 0.60 |
| Endothelial | contributes_to | cell_type | 0.60 |
| Pericyte | contributes_to | cell_type | 0.60 |
| App | contributes_to | protein | 0.60 |
| AMYLOID | expressed_in | gene | 0.60 |
| DEMENTIA | expressed_in | gene | 0.60 |
| Tgf-Β | activates | pathway | 0.60 |
| White Matter | expressed_in | brain_region | 0.55 |
| Proteins | interacts_with | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning HTRA1 in their description or question text
No additional research found