protein

TRANSFERRIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRANSFERRIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

139Connections

3Hypotheses

0Analyses

50Outgoing

50Incoming

6Experiments

0Debates

Summary

Page for Transferrin Protein

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🔬 Protein Info

Gene Symbol	TRANSFERRIN
Chromosome	3q21.
Molecular Weight	80 kDa
Amino Acids	679 aa
Pathways	Blood-Brain Barrier, Oxidative Stress, Autophagy, Mitophagy, Mitochondrial Function
GeneCards	TRANSFERRIN
Human Protein Atlas	TRANSFERRIN
Associated Diseases	cancer, ferroptosis, ISCHEMIA
Interactions	FERROPORTIN, GPX4, HEPCIDIN, IGF2R, Proteins, SLC7A11
KG Connections	37 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Transferrin Protein

redirect · 668 words

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Pathway Diagram

graph TD
    TRANSFERRIN["TRANSFERRIN"]
    IRON_METABOLISM["IRON METABOLISM"]
    TRANSFERRIN -->|"involved in"| IRON_METABOLISM
    TFR1["TFR1"]
    TRANSFERRIN -->|"binds"| TFR1
    TFR1["TFR1"]
    TFR1 -->|"binds"| TRANSFERRIN
    TRANSFERRIN_RECEPTOR_1["TRANSFERRIN RECEPTOR 1"]
    TRANSFERRIN_RECEPTOR_1 -->|"binds to"| TRANSFERRIN
    TRANSFERRIN_RECEPTOR_2["TRANSFERRIN RECEPTOR 2"]
    TRANSFERRIN_RECEPTOR_2 -->|"binds to"| TRANSFERRIN
    TFR2["TFR2"]
    TFR2 -->|"binds"| TRANSFERRIN
    TXB2["TXB2"]
    TXB2 -->|"associated with"| TRANSFERRIN
    ISCHEMIA["ISCHEMIA"]
    TRANSFERRIN -->|"associated with"| ISCHEMIA
    FERROPORTIN["FERROPORTIN"]
    TRANSFERRIN -->|"associated with"| FERROPORTIN
    MACROPHAGES["MACROPHAGES"]
    TRANSFERRIN -->|"associated with"| MACROPHAGES
    HEPATOCYTES["HEPATOCYTES"]
    TRANSFERRIN -->|"associated with"| HEPATOCYTES
    ferroptosis["ferroptosis"]
    TRANSFERRIN -->|"associated with"| ferroptosis
    BLOOD_BRAIN_BARRIER["BLOOD-BRAIN BARRIER"]
    TRANSFERRIN -->|"activates"| BLOOD_BRAIN_BARRIER
    Proteins["Proteins"]
    TRANSFERRIN -->|"activates"| Proteins
    Proteins["Proteins"]
    TRANSFERRIN -->|"regulates"| Proteins
    Genes["Genes"]
    TRANSFERRIN -->|"interacts with"| Genes
    ST6GAL1["ST6GAL1"]
    TRANSFERRIN -->|"interacts with"| ST6GAL1
    FUT8["FUT8"]
    TRANSFERRIN -->|"interacts with"| FUT8
    IGF2R["IGF2R"]
    TRANSFERRIN -->|"interacts with"| IGF2R
    SORTILIN["SORTILIN"]
    TRANSFERRIN -->|"interacts with"| SORTILIN
    INSULIN["INSULIN"]
    TRANSFERRIN -->|"interacts with"| INSULIN
    BLOOD_BRAIN_BARRIER["BLOOD-BRAIN BARRIER"]
    TRANSFERRIN -->|"associated with"| BLOOD_BRAIN_BARRIER
    BLOOD_BRAIN_BARRIER["BLOOD-BRAIN BARRIER"]
    TRANSFERRIN -->|"interacts with"| BLOOD_BRAIN_BARRIER
    cancer["cancer"]
    TRANSFERRIN -->|"associated with"| cancer
    FERROPORTIN["FERROPORTIN"]
    TRANSFERRIN -->|"interacts with"| FERROPORTIN
    HEPCIDIN["HEPCIDIN"]
    TRANSFERRIN -->|"interacts with"| HEPCIDIN
    ferroptosis["ferroptosis"]
    TRANSFERRIN -->|"activates"| ferroptosis
    GLUTAMATE["GLUTAMATE"]
    TRANSFERRIN -->|"activates"| GLUTAMATE
    CATALASE["CATALASE"]
    TRANSFERRIN -->|"associated with"| CATALASE
    FERROPORTIN["FERROPORTIN"]
    TRANSFERRIN -->|"regulates"| FERROPORTIN

Outgoing (61)

Target	Relation	Type	Str
IRON METABOLISM	involved_in	entity	0.95
Glycosylation	involved_in	process	0.95
Iron	binds	compound	0.90
Tfr1	binds	receptor	0.90
Iron	delivers	chemical	0.90
NEURON	transports	cell_type	0.90
Transferrin Receptor 1	activates	protein	0.80
hepatocytes	binds	cell	0.80
IgG	co_expressed_with	protein	0.75
Ischemia	causes	disease	0.60
Ischemia	associated_with	disease	0.60
Als	regulates	disease	0.60
Cancer	regulates	disease	0.60
Ferroptosis	biomarker_for	disease	0.60
Lymphoma	biomarker_for	disease	0.60
Cancer	biomarker_for	disease	0.60
Als	biomarker_for	disease	0.60
Aging	therapeutic_target	disease	0.60
Alzheimer	therapeutic_target	disease	0.60
Als	therapeutic_target	disease	0.60
Dementia	causes	disease	0.60
Alzheimer	causes	disease	0.60
Ferroptosis	causes	disease	0.60
Als	causes	disease	0.60
Parkinson	interacts_with	disease	0.60
Cancer	therapeutic_target	disease	0.60
Alzheimer	expressed_in	disease	0.60
Fibrosis	activates	disease	0.60
Diabetes	inhibits	disease	0.60
Ferroptosis	inhibits	disease	0.60
Cancer	activates	disease	0.60
Mitochondrial Function	activates	pathway	0.55
Oxidative Stress	activates	pathway	0.55
Autophagy	activates	pathway	0.55
Mitophagy	activates	pathway	0.55
Blood-Brain Barrier	activates	pathway	0.55
Blood-Brain Barrier	therapeutic_target	pathway	0.55
Oxidative Stress	biomarker_for	pathway	0.55
Blood-Brain Barrier	associated_with	pathway	0.55
Proteins	regulates	protein	0.50
ST6GAL1	interacts_with	concept	0.50
FUT8	interacts_with	concept	0.50
IGF2R	interacts_with	protein	0.50
SORTILIN	interacts_with	protein	0.50
INSULIN	interacts_with	concept	0.50
cancer	associated_with	disease	0.50
FERROPORTIN	interacts_with	protein	0.50
HEPCIDIN	interacts_with	protein	0.50
ferroptosis	activates	phenotype	0.50
GLUTAMATE	activates	concept	0.50

Incoming (78)

Source	Relation	Type	Str
TRANSFERRIN RECEPTOR 1	binds_to	entity	0.95
TRANSFERRIN RECEPTOR 2	binds_to	entity	0.90
Transferrin Receptor 1	binds	receptor	0.90
Transferrin Receptor 2	binds	protein	0.90
TXB2	associated_with	compound	0.85
TXB2	associated_with	drug	0.75
JUN	regulates	gene	0.60
FERROPORTIN	transports	gene	0.60
DMT1	transports	gene	0.60
TFR1	transports	gene	0.60
TFR1	activates	gene	0.60
TAU	therapeutic_target	gene	0.60
GPX4	causes	gene	0.60
TAU	causes	gene	0.60
FUT8	associated_with	gene	0.60
ST6GAL1	associated_with	gene	0.60
IGF2R	therapeutic_target	gene	0.60
GBA1	interacts_with	gene	0.60
TFRC	interacts_with	gene	0.60
HFE	regulates	gene	0.60
TFR1	interacts_with	gene	0.60
JUN	therapeutic_target	gene	0.60
GPX4	inhibits	gene	0.60
VDR	inhibits	gene	0.60
SLC7A11	inhibits	gene	0.60
MAP2	regulates	gene	0.60
APOE	regulates	gene	0.60
GPX4	regulates	gene	0.60
FERROPORTIN	regulates	gene	0.60
FERROPTOSIS	inhibits	gene	0.60
GSH	inhibits	gene	0.60
TFR1	associated_with	gene	0.60
JUN	interacts_with	gene	0.60
TFR1	regulates	gene	0.60
ROS	activates	gene	0.60
DNA	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
FERROPTOSIS	biomarker_for	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
AMYLOID-BETA	therapeutic_target	gene	0.60
ALZHEIMER	causes	gene	0.60
DEMENTIA	causes	gene	0.60
FERROPTOSIS	causes	gene	0.60
MICROGLIA	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
ASTROCYTES	therapeutic_target	gene	0.60
MALAT1	therapeutic_target	gene	0.60
PARKINSON	interacts_with	gene	0.60
RNA	activates	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
pH-Sensitive Bispecific Antibody Targeting Transferrin Recep	0.800	neurodegeneration	Blood-brain barrier antibody transport m
Magnetosonic-Triggered Transferrin Receptor Clustering	0.719	neurodegeneration	Blood-brain barrier transport mechanisms
Transferrin-Alectinib Conjugation Enhances Blood-Brain Barri	0.406	molecular biology	Does Alectinib truly bind C1q directly w

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (6)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Autophagy receptor identification for stress granule elimination	exploratory	neurodegenerative diseases	0.900	0.00	cultured cells under arsenite	proposed	N/A
iPSC-derived endothelial cell iron uptake with RLS CSF exposure	exploratory	restless legs syndrome	0.900	0.00	iPSC-derived human endothelial	proposed	N/A
s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice with engin	falsification	Neuroinflammation	0.400	0.50	mouse	proposed	$200,000
s:** - Compare uptake with/without magnetic particles using tight junc	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$120,000
AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Therapy	validation	Parkinson's Disease	0.400	0.50	mouse	proposed	$280,000
AAV Serotype Comparison for LRRK2 Knockdown in PD	validation	Parkinson's Disease	0.400	0.50	mouse	proposed	$280,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease. [PMID:40425446]	Sehlin D, Hultqvist G, Michno W, Aguilar	J Prev Alzheimers Dis	2025	1
Effect of ferroptosis on chronic cerebral hypoperfusion in vascular dementia. [PMID:37709116]	Fu P, Chen Y, Wu M, Bao B, Yin X, Chen Z	Exp Neurol	2023	1
On Iron Metabolism and Its Regulation. [PMID:33925597]	Vogt AS, Arsiwala T, Mohsen M, Vogel M,	Int J Mol Sci	2021	1
Transferrin Receptor Is a Specific Ferroptosis Marker. [PMID:32160546]	Feng H, Schorpp K, Jin J, Yozwiak CE, Ho	Cell Rep	2020	1
Transferrin and transferrin receptors update. [PMID:29969719]	Kawabata H	Free Radic Biol Med	2019	1
Time- and dose-dependent effects of bacterial infection on iron metabolism, infl [PMID:41619877]	Lu Y, Zhang Y, Niu C	Comp Biochem Physiol A Mol Int	2026	0
Ayanin combats against barium sulphate nanoparticles induced hepatotoxicity via [PMID:41666660]	Zhu D, Lu Y, Jamil S, Ashfaq H, Al-Emam	J Trace Elem Med Biol	2026	0
Role of iron and TfR1 in the application of high‑dose ascorbate against pancreat [PMID:41789665]	Piotrowsky A, Leischner C, Schmieder H,	Oncol Rep	2026	0
Yangxin granules exert cardioprotective effects against acute myocardial infarct [PMID:41868900]	Huo G, Zhou Y, Wu Z, Sun S, Zhu G, Cheng	American journal of translatio	2026	0
Conformational dynamics study of TfR1 upon transferrin binding via NMA and MD si [PMID:41921418]	Zemmouche M, Falque G, Cadet F, Gardebie	Journal of molecular graphics	2026	0
[Effects of acupuncture on ferroptosis and ferritinophagy in cerebral ischemia-r [PMID:41839581]	Wang YF, Dong YS	Zhen ci yan jiu = Acupuncture	2026	0
The therapeutic potential of Piezo1 channel-mediated ferroptosis and its inhibit [PMID:41854751]	Nan K, Zhang L, Zhao Y, Yin S, Peng Y, H	Apoptosis : an international j	2026	0
The Role of Artemisinin and its Derivatives in Cancer Therapy via Ferroptosis: A [PMID:41833023]	Osmanlioglu Dag SR, Tatli Cankaya II, Oz	Anti-cancer agents in medicina	2026	0
Raccoon eyes [PMID:35789012]	Ning Junjie	Journal of Paediatrics and Chi	2023	0
The Trend of Immunotherapy Combined with Nanomedicine. [PMID:34789123]	Shigao Huang; Qi Zhao	Current medicinal chemistry	2022	0
Test-retest reliability for performance-based outcome measures among individuals [PMID:35123456]	["Sions J", "Donohoe M", "Beisheim-Ryan	BMC musculoskeletal disorders	2022	0
Interfacial Imide Polymerization of Functionalized Filled Microcapsule Templates [PMID:36234567]	["Wei Z", "Ma X", "Wang P", "Pan J"]	Nanomaterials (Basel, Switzerl	2022	0
The impact of COVID-19 and non-pharmaceutical interventions on energy returns wo [PMID:36567890]	["Saif-Alyousfi A", "Saha A"]	Sustainable cities and society	2021	0
Implications of relationships with family, friends, and neighbors for changes in [PMID:33245678]	["Fuller H"]	Journal of women & aging	2021	0
[Longitudinal Direct Closure of Mitral Anterior Leaflet Large Perforation for In [PMID:34876543]	Morizumi S, Enomoto Y, Ikeda K, Suzuki Y	Kyobu geka. The Japanese journ	2021	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TRANSFERRIN in their description or question text

No additional research found