gene

NOTCH3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NOTCH3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

92Connections

0Hypotheses

0Analyses

50Outgoing

29Incoming

0Experiments

0Debates

Summary

NOTCH3 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, contributes to, activates. Associated with Aging, Als, Autoimmune. Connected to 47 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NOTCH3
Full Name	Notch Receptor 3
Aliases	Notch 3
Chromosome	19p13.12
Protein Type	Receptor
Function	is a single-pass transmembrane receptor belonging to the Notch family of signaling proteins (NOTCH1-4 in mammals).
Primary Expression	Vascular smooth muscle cells, Pericytes, some neurons
Molecular Weight	270 kDa
Amino Acids	321 aa
Pathways	NOTCH, Notch, Notch Signaling, Notch signaling
UniProt ID	Q9UM47
NCBI Gene ID	4854
Ensembl ID	ENSG00000074181
OMIM	600276
GeneCards	NOTCH3
Human Protein Atlas	NOTCH3
Associated Diseases	Als, Alzheimer's disease
Interactions	AHR, AND, ANGPT1, BACE1, CANCER, FLCN
KG Connections	92 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NOTCH3 — AlphaFold Q9UM47 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NOTCH3["NOTCH3"]
    Als{"Als"}
    NOTCH3 -->|"activates"| Als
    Neuroinflammation{"Neuroinflammation"}
    NOTCH3 -->|"regulates"| Neuroinflammation
    Autoimmune{"Autoimmune"}
    NOTCH3 -->|"regulates"| Autoimmune
    Inflammation{"Inflammation"}
    NOTCH3 -->|"regulates"| Inflammation
    Multiple_Sclerosis{"Multiple Sclerosis"}
    NOTCH3 -->|"regulates"| Multiple_Sclerosis
    Ms{"Ms"}
    NOTCH3 -->|"activates"| Ms
    Dementia{"Dementia"}
    NOTCH3 -->|"contributes to"| Dementia
    Aging{"Aging"}
    NOTCH3 -->|"contributes to"| Aging
    NOTCH3 -->|"contributes to"| Als
    Stroke{"Stroke"}
    NOTCH3 -->|"contributes to"| Stroke
    Glioblastoma{"Glioblastoma"}
    NOTCH3 -->|"expressed in"| Glioblastoma
    NOTCH3 -->|"expressed in"| Als
    MTOR["MTOR"]
    MTOR -->|"expressed in"| NOTCH3
    TLR4["TLR4"]
    TLR4 -->|"activates"| NOTCH3
    PI3K["PI3K"]
    PI3K -->|"expressed in"| NOTCH3
    SOD2["SOD2"]
    SOD2 -->|"activates"| NOTCH3
    AKT["AKT"]
    AKT -->|"expressed in"| NOTCH3
    SOD1["SOD1"]
    SOD1 -->|"activates"| NOTCH3
    CANCER["CANCER"]
    CANCER -->|"activates"| NOTCH3
    EP300["EP300"]
    EP300 -->|"regulates"| NOTCH3
    style NOTCH3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (63)

Target	Relation	Type	Str
Stroke	contributes_to	disease	0.75
Dementia	contributes_to	disease	0.75
Aging	contributes_to	disease	0.75
Cirrhosis	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
Autoimmune	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Multiple Sclerosis	regulates	disease	0.65
Ms	activates	disease	0.65
Als	activates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Cardiovascular	activates	disease	0.65
ALS	activates	disease	0.65
Glioblastoma	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Cancer	activates	disease	0.65
Als	associated_with	disease	0.65
Ms	regulates	disease	0.65
Migraine	contributes_to	disease	0.65
Alzheimer's disease	associated_with	disease	0.60
FLCN	activates	gene	0.60
NOTCH1	activates	gene	0.60
NF1	activates	gene	0.60
ANGPT1	activates	gene	0.60
STROKE	contributes_to	gene	0.60
DEMENTIA	contributes_to	gene	0.60
Notch	expressed_in	pathway	0.60
TGF-beta signaling	participates_in	pathway	0.60
Raf	activates	protein	0.60
endothelial cells	expressed_in	cell_type	0.60
WNT	activates	gene	0.60
AHR	activates	gene	0.60
Wnt	activates	pathway	0.60
VEGF	activates	gene	0.60
GENES	contributes_to	gene	0.60
Notch	associated_with	pathway	0.60
RAN	associated_with	gene	0.60
SOD1	activates	gene	0.60
AKT	expressed_in	gene	0.60
MTOR	expressed_in	gene	0.60
Rb	activates	protein	0.60
CANCER	activates	gene	0.60
GLIOBLASTOMA	expressed_in	gene	0.60
Angiogenesis	activates	pathway	0.60
Endothelial	contributes_to	cell_type	0.60
Pericyte	contributes_to	cell_type	0.60
App	contributes_to	protein	0.60
COL4A1	contributes_to	gene	0.60
OVERVIEW	contributes_to	gene	0.60

Incoming (29)

Source	Relation	Type	Str
APP	associated_with	gene	0.60
LDLR	associated_with	gene	0.60
NOTCH1	activates	gene	0.60
FLCN	activates	gene	0.60
NF1	activates	gene	0.60
AHR	activates	gene	0.60
VEGF	activates	gene	0.60
HTRA1	contributes_to	gene	0.60
OVERVIEW	contributes_to	gene	0.60
JAG1	associated_with	gene	0.60
BACE1	inhibits	gene	0.60
CANCER	activates	gene	0.60
GENES	expressed_in	gene	0.60
AND	activates	gene	0.60
EP300	regulates	gene	0.60
GENES	activates	gene	0.60
WNT	activates	gene	0.60
ANGPT1	activates	gene	0.60
ABCC8	associated_with	gene	0.60
AQP1	associated_with	gene	0.60
BMPR1A	associated_with	gene	0.60
BMPR1B	associated_with	gene	0.60
MTOR	expressed_in	gene	0.60
TLR4	activates	gene	0.60
PI3K	expressed_in	gene	0.60
SOD2	activates	gene	0.60
AKT	expressed_in	gene	0.60
SOD1	activates	gene	0.60
DEMENTIA	contributes_to	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NOTCH3 in their description or question text

No additional research found