gene

APOC2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about APOC2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

128Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

A gene referenced in 116 knowledge graph relationships. Key connections: causes hypertriglyceridemia (disease); activates JAK-STAT signaling pathway (pathway); associated_with Dementia (disease).

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🧬 Gene Info

Gene Symbol	APOC2
Chromosome	19q13.32
Function	LPL Activation: APOC2 is the essential cofactor for lipoprotein lipase
Primary Expression	the liver and small intestine
Molecular Weight	8.8 kDa
Amino Acids	79 aa
Exons	4
Pathways	Cholesterol
Ensembl ID	ENSG00000134901
GeneCards	APOC2
Human Protein Atlas	APOC2
Nutritional status	Increased by high-carbohydrate diets
Insulin	Suppresses APOC2 expression
PPAR agonists	Fibrates modulate APOC2 levels
Inflammatory cytokines	TNF-α and IL-6 reduce expression
Associated Diseases	Aging, Als, Alzheimer, Dementia, hypertriglyceridemia, Ms
Interactions	ABCA1, ABCA2, APOA1, APOC1, APOC3, APOD
KG Connections	116 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

APOC2 Gene

gene · 839 words

→

APOC2 Protein

protein · 635 words

→

Pathway Diagram

flowchart TD
    A["APOC2"] --> B["Lipoprotein Lipase Activation"]
    A --> C["Triglyceride Hydrolysis"]
    B --> C
    A --> D["JAK-STAT Pathway"]
    C --> E["FFA Release"]
    D --> F["Inflammatory Signaling"]
    E --> G["Hypertriglyceridemia"]
    G --> H["Endothelial Dysfunction"]
    F --> I["Dementia Progression"]
    H --> I

Outgoing (59)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:APOC2	data_in	dataset_row	0.00
hypertriglyceridemia	causes	disease	0.80
JAK-STAT signaling pathway	activates	pathway	0.80
Atherosclerosis	degrades	disease	0.65
Alzheimer	degrades	disease	0.65
Als	degrades	disease	0.65
ALS	transports	disease	0.65
Alzheimer	transports	disease	0.65
Dementia	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Carcinoma	biomarker_for	disease	0.65
Tumor	biomarker_for	disease	0.65
Atherosclerosis	regulates	disease	0.65
Atherosclerosis	transports	disease	0.65
Als	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
LIPA	degrades	gene	0.60
APOE	activates	gene	0.60
CYP46A1	activates	gene	0.60
LRP1	activates	gene	0.60
LRP8	activates	gene	0.60
Lipid Metabolism	associated_with	pathway	0.60
Cholesterol	associated_with	pathway	0.60
APOD	activates	gene	0.60
TFCP2	degrades	gene	0.60
App	degrades	protein	0.60
CH25H	activates	gene	0.60
lipid metabolism	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.60
MCC	associated_with	gene	0.60
CAT	associated_with	gene	0.60
APOA1	associated_with	gene	0.60
LZTS1	associated_with	gene	0.60
COL4A1	associated_with	gene	0.60
SOAT1	activates	gene	0.60
ABCA2	activates	gene	0.60
PSEN2	regulates	gene	0.60
TAU	regulates	gene	0.60
LDLR	activates	gene	0.60
APOC3	activates	gene	0.60
TAU	degrades	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AMYLOID	associated_with	gene	0.60
Cholesterol	activates	pathway	0.60
Neuron	activates	cell_type	0.60

Incoming (69)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:APOC2	data_in	dataset_row	0.00
ALZHEIMER	degrades	gene	0.60
ACOX1	associated_with	gene	0.60
CH25H	activates	gene	0.60
ALZHEIMER	regulates	gene	0.60
APOD	activates	gene	0.60
TFCP2	regulates	gene	0.60
TFCP2	transports	gene	0.60
AND	transports	gene	0.60
ALZHEIMER'S DISEASE	transports	gene	0.60
CH25H	transports	gene	0.60
APOD	transports	gene	0.60
GENES	transports	gene	0.60
ALZHEIMER	transports	gene	0.60
APOE4	associated_with	gene	0.60
APOA2	associated_with	gene	0.60
APOC3	activates	gene	0.60
APP	degrades	gene	0.60
PSEN2	degrades	gene	0.60
MAPT	degrades	gene	0.60
SREBF1	degrades	gene	0.60
NCSTN	degrades	gene	0.60
PSEN1	degrades	gene	0.60
LDLR	activates	gene	0.60
SOAT1	activates	gene	0.60
GSK3B	degrades	gene	0.60
AGING	associated_with	gene	0.60
COL4A1	associated_with	gene	0.60
LZTS1	associated_with	gene	0.60
LRP8	activates	gene	0.60
APOA1	activates	gene	0.60
MAPT	regulates	gene	0.60
LRP1	activates	gene	0.60
LIPA	regulates	gene	0.60
APP	regulates	gene	0.60
APOE	activates	gene	0.60
CYP46A1	activates	gene	0.60
ABCA1	activates	gene	0.60
NCSTN	regulates	gene	0.60
GSK3B	regulates	gene	0.60
PSEN1	regulates	gene	0.60
SREBF1	regulates	gene	0.60
APOC1	activates	gene	0.60
APOE	transports	gene	0.60
NCSTN	transports	gene	0.60
PSEN2	transports	gene	0.60
LIPA	transports	gene	0.60
LDLR	transports	gene	0.60
ABCA1	transports	gene	0.60
GSK3B	transports	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning APOC2 in their description or question text

No additional research found