gene

NF2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

119Connections

0Hypotheses

0Analyses

50Outgoing

42Incoming

0Experiments

0Debates

Summary

NF2 tumor suppressor (Merlin/Schwannomin) in neurofibromatosis, CNS tumors and neurodegeneration

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🧬 Gene Info

Gene Symbol	NF2
Full Name	NF2 (Neurofibromin 2 / Merlin)
Aliases	Merlin/Schwannomin
Chromosome	22q12.2
Function	NF2 encodes neurofibromin 2, also known as merlin (moesin-ezrin-radixin-like protein) or schwannomin.
Primary Expression	High in Schwann cells, meninges, cerebellum (Purkinje cells), neurons
Subcellular Localization	and function. Cell-cell contact promotes the open, active conformation
Molecular Weight	66 kDa
Amino Acids	595 aa
Pathways	mTOR signaling, mTOR Signaling, mTOR
UniProt ID	P35240
NCBI Gene ID	4780
Ensembl ID	ENSG00000108775
OMIM	607402
GeneCards	NF2
Human Protein Atlas	NF2
Associated Diseases	Als, Ms, neurofibromatosis type 2, Tumor
Interactions	AKT, AND, CANCER, CDH1, EGFR, ERK
KG Connections	119 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NF2 — AlphaFold P35240 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NF2["NF2"]
    neurofibromatosis_type_2{"neurofibromatosis type 2"}
    NF2 -->|"causes"| neurofibromatosis_type_2
    Tumor{"Tumor"}
    NF2 -->|"causes"| Tumor
    PI3K_AKT(["PI3K/AKT"])
    NF2 -->|"regulates"| PI3K_AKT
    RAF_MEK_ERK(["RAF/MEK/ERK"])
    NF2 -->|"regulates"| RAF_MEK_ERK
    MAPK(["MAPK"])
    NF2 -->|"regulates"| MAPK
    merlin["merlin"]
    NF2 -->|"encodes"| merlin
    Cardiovascular["Cardiovascular"]
    NF2 -->|"regulates"| Cardiovascular
    Als{"Als"}
    NF2 -->|"associated with"| Als
    Ms{"Ms"}
    NF2 -->|"inhibits"| Ms
    NF2 -->|"inhibits"| Tumor
    Cancer{"Cancer"}
    NF2 -->|"interacts with"| Cancer
    NF2 -->|"activates"| Cancer
    MTOR["MTOR"]
    MTOR -->|"inhibits"| NF2
    ERK["ERK"]
    ERK -->|"inhibits"| NF2
    PI3K["PI3K"]
    PI3K -->|"inhibits"| NF2
    AKT["AKT"]
    AKT -->|"inhibits"| NF2
    FERROPTOSIS["FERROPTOSIS"]
    FERROPTOSIS -->|"interacts with"| NF2
    CANCER["CANCER"]
    CANCER -->|"interacts with"| NF2
    YAP["YAP"]
    YAP -->|"interacts with"| NF2
    MEF2C["MEF2C"]
    MEF2C -->|"activates"| NF2
    LAMA2["LAMA2"]
    LAMA2 -->|"regulates"| NF2
    BCL2L13["BCL2L13"]
    BCL2L13 -->|"associated with"| NF2
    style NF2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (77)

Target	Relation	Type	Str
neurofibromatosis type 2	causes	disease	0.90
RAF/MEK/ERK	regulates	pathway	0.80
MAPK	regulates	pathway	0.80
Tumor	causes	disease	0.80
PI3K/AKT	regulates	pathway	0.80
Als	associated_with	disease	0.75
Tumor	associated_with	disease	0.75
GENES	inhibits	gene	0.70
merlin	encodes	protein	0.70
LZTR1	inhibits	gene	0.70
Als	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Als	treats	disease	0.65
Tumor	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
Ms	associated_with	disease	0.65
Cancer	activates	disease	0.65
Cancer	interacts_with	disease	0.65
Als	activates	disease	0.65
Ms	regulates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Ms	activates	disease	0.65
Epigenetic	inhibits	pathway	0.60
Mapk	activates	pathway	0.60
Raf	therapeutic_target	protein	0.60
Akt	therapeutic_target	protein	0.60
Fgf	therapeutic_target	protein	0.60
Egfr	therapeutic_target	protein	0.60
APOPTOSIS	associated_with	gene	0.60
Ras	therapeutic_target	protein	0.60
Apoptosis	associated_with	pathway	0.60
Pi3K	activates	pathway	0.60
Akt	activates	pathway	0.60
LZTR1	causes	gene	0.60
GENES	causes	gene	0.60
Mtor	implicated_in	pathway	0.60
Hedgehog	implicated_in	pathway	0.60
RAS	inhibits	gene	0.60
Pi3K/Akt	inhibits	pathway	0.60
HEDGEHOG	contributes_to	gene	0.60
Differentiation	therapeutic_target	pathway	0.60
Notch	implicated_in	pathway	0.60
Tgf-Β	implicated_in	pathway	0.60
DNA	associated_with	gene	0.60
Wnt	implicated_in	pathway	0.60
Mtor	inhibits	pathway	0.60
Pi3K	inhibits	pathway	0.60
Akt	inhibits	pathway	0.60

Incoming (42)

Source	Relation	Type	Str
NF1	associated_with	gene	0.70
SMARCB1	inhibits	gene	0.70
YAP	interacts_with	gene	0.60
SMARCB1	implicated_in	gene	0.60
VEGF	therapeutic_target	gene	0.60
SMARCB1	causes	gene	0.60
GAIN	therapeutic_target	gene	0.60
VEGF	inhibits	gene	0.60
PTEN	therapeutic_target	gene	0.60
BRAF	therapeutic_target	gene	0.60
EGFR	therapeutic_target	gene	0.60
AKT1	therapeutic_target	gene	0.60
FERROPTOSIS	interacts_with	gene	0.60
NF1	therapeutic_target	gene	0.60
CANCER	interacts_with	gene	0.60
WNT	contributes_to	gene	0.60
RNA	therapeutic_target	gene	0.60
KRAS	therapeutic_target	gene	0.60
MEF2C	activates	gene	0.60
NOTCH	contributes_to	gene	0.60
HIPPO	contributes_to	gene	0.60
ONCOGENES	activates	gene	0.60
MAPK	activates	gene	0.60
P16	inhibits	gene	0.60
RASSF1A	inhibits	gene	0.60
GENES	inhibits	gene	0.60
HIPPO	activates	gene	0.60
MTOR	inhibits	gene	0.60
PI3K	inhibits	gene	0.60
AKT	inhibits	gene	0.60
LAMA2	regulates	gene	0.60
BCL2L13	associated_with	gene	0.60
ERK	inhibits	gene	0.60
LZTR1	contributes_to	gene	0.60
GENES	implicated_in	gene	0.60
HIPPO	implicated_in	gene	0.60
AND	inhibits	gene	0.60
MTOR	contributes_to	gene	0.60
MET	activates	gene	0.60
EGFR	activates	gene	0.60
AKT	activates	gene	0.60
PI3K	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NF2 in their description or question text

No additional research found

NF2

Understanding Entity Pages

Summary

Wiki Pages (7)

NF2 — Merlin/Neurofibromin 2

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