concept

HIPPO

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HIPPO: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

643Connections

30Hypotheses

0Analyses

50Outgoing

50Incoming

15Experiments

0Debates

Summary

HIPPO is a concept in neurodegeneration research. Key relationships include: regulates, activates, therapeutic target. Associated with Aging, Als, Alzheimer. Connected to 425 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	HIPPO
Key Genes/Proteins	ABCB1, ACSL4, Actin, AGING, AKT, ALS
Related Diseases	Addiction, Aging, Als, Alzheimer
Related Pathways	Akt, Amyloid

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Hippo Signaling Pathway in Neurodegeneration

mechanism · 1922 words

→

Pathway Diagram

graph TD
    HIPPO["HIPPO"]
    HIPPO -->|"interacts"| FoxO1["FoxO1"]
    HIPPO -->|"regulates"| TNF_["TNFalpha"]
    HIPPO -->|"regulates"| IL_6["IL-6"]
    HIPPO -->|"regulates"| Carcinoma["Carcinoma"]
    HIPPO -->|"regulates"| Als["Als"]
    HIPPO -->|"target for"| Ms["Ms"]
    HIPPO -->|"target for"| Inflammation["Inflammation"]
    HIPPO -->|"activates"| Cancer["Cancer"]
    HIPPO -->|"target for"| Tumor["Tumor"]
    CDH1["CDH1"] -->|"regulates"| HIPPO
    MPXV["MPXV"] -->|"regulates"| HIPPO
    MTOR["MTOR"] -->|"regulates"| HIPPO
    AGING["AGING"] -->|"inhibits"| HIPPO
    GAL["GAL"] -->|"regulates"| HIPPO
    FOS["FOS"] -->|"contributes to"| HIPPO
    MT_ATP6["MT-ATP6"] -->|"regulates"| HIPPO
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"regulates"| HIPPO
    PI3K["PI3K"] -->|"regulates"| HIPPO

Outgoing (414)

Target	Relation	Type	Str
Cancer	regulates	disease	1.00
Cancer	therapeutic_target	disease	1.00
Tumor	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Hippo Pathway	regulates	pathway	1.00
YAP	activates	gene	1.00
Apoptosis	regulates	pathway	0.90
Als	regulates	disease	0.85
Cancer	activates	disease	0.85
Tumor	regulates	disease	0.85
Gastric Cancer	associated_with	disease	0.80
AKT	activates	gene	0.80
CANCER	activates	gene	0.80
YAP	regulates	gene	0.80
YAP	associated_with	gene	0.80
Apoptosis	activates	pathway	0.80
MYC	activates	gene	0.80
CANCER	therapeutic_target	gene	0.80
Differentiation	therapeutic_target	pathway	0.80
Carcinoma	regulates	disease	0.75
Inflammation	therapeutic_target	disease	0.75
Als	associated_with	disease	0.75
Als	activates	disease	0.75
Tumor	activates	disease	0.75
Autophagy	activates	pathway	0.70
Wnt	associated_with	pathway	0.70
FoxO1	interacts_with	protein	0.70
INFLAMMATION	therapeutic_target	gene	0.70
TNFα	regulates	protein	0.70
CANCER	regulates	gene	0.70
FERROPTOSIS	regulates	gene	0.70
EGF	activates	gene	0.70
Epigenetic	therapeutic_target	pathway	0.70
Hedgehog	regulates	pathway	0.70
Mtor	regulates	pathway	0.70
Tgf-Β	associated_with	pathway	0.70
Angiogenesis	therapeutic_target	pathway	0.70
Metastasis	therapeutic_target	pathway	0.70
Hippo Pathway	associated_with	pathway	0.70
Ferroptosis	regulates	pathway	0.70
Oxidative Stress	regulates	pathway	0.70
IL-6	regulates	protein	0.70
STAT3	associated_with	gene	0.70
AKT	therapeutic_target	gene	0.70
Autophagy	regulates	pathway	0.70
YAP1	activates	gene	0.70
Hippo Pathway	therapeutic_target	pathway	0.70
GENES	regulates	gene	0.70
Cardiac	contributes_to	disease	0.65
Ms	contributes_to	disease	0.65

Incoming (229)

Source	Relation	Type	Str
CANCER	regulates	gene	0.80
APOPTOSIS	regulates	gene	0.80
TAZ	regulates	gene	0.70
PI3K	therapeutic_target	gene	0.70
APOPTOSIS	activates	gene	0.70
MST1	regulates	gene	0.70
PI3K	associated_with	gene	0.70
OXIDATIVE STRESS	regulates	gene	0.70
CDH1	regulates	gene	0.70
CANCER	therapeutic_target	gene	0.70
EGFR	activates	gene	0.70
PI3K	activates	gene	0.70
CLCN8	associated_with	gene	0.70
MPXV	regulates	disease	0.64
IL-6	activates	gene	0.60
HEDGEHOG	activates	gene	0.60
IKBKB	phosphorylates	gene	0.60
CHUK	phosphorylates	gene	0.60
P53	therapeutic_target	gene	0.60
RNA	associated_with	gene	0.60
SCN5A	associated_with	gene	0.60
JAK	activates	gene	0.60
ROS	therapeutic_target	gene	0.60
TP53	regulates	gene	0.60
NF-ΚB	regulates	gene	0.60
PTEN	therapeutic_target	gene	0.60
AMPK	therapeutic_target	gene	0.60
WNT	activates	gene	0.60
AND	associated_with	gene	0.60
HDAC2	regulates	protein	0.60
FERROPTOSIS	regulates	gene	0.60
BIP	activates	gene	0.60
ERK	inhibits	gene	0.60
SRC	inhibits	gene	0.60
MIRNAS	activates	gene	0.60
KCNK2	associated_with	gene	0.60
TCR	associated_with	gene	0.60
AXON	activates	gene	0.60
CFTR	associated_with	gene	0.60
TRPV4	associated_with	gene	0.60
CACNA1B	associated_with	gene	0.60
CACNA1C	associated_with	gene	0.60
SCN1A	associated_with	gene	0.60
GENES	activates	gene	0.60
KCNN4	associated_with	gene	0.60
TRPM7	associated_with	gene	0.60
TRPA1	associated_with	gene	0.60
SCNN1A	associated_with	gene	0.60
PIEZO2	associated_with	gene	0.60
MYC	activates	gene	0.60

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop transcranial focused ultrasound with 40Hz gamma	1.000	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.948	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.922	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.912	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic restoration of hippocampal gamma oscillations vi	0.863	Alzheimer's disease	Circuit-level neural dynamics in neurode

Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95	0.861	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.858	Alzheimer's disease	Circuit-level neural dynamics in neurode
Gamma entrainment therapy to restore hippocampal-cortical sy	0.851	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic viral vector delivery via tFUS-mediated blood-br	0.846	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic restoration of hippocampal gamma oscillations vi	0.845	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.827	Alzheimer's disease	Circuit-level neural dynamics in neurode
Real-time gamma-guided transcranial focused ultrasound targe	0.827	Alzheimer's disease	Circuit-level neural dynamics in neurode
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna	0.820	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting CA1 PV	0.797	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial alternating current stimulation to	0.785	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.767	Alzheimer's disease	Circuit-level neural dynamics in neurode
Cholinergic Basal Forebrain-Hippocampal Circuit Protection	0.742	neuroscience	Circuit-level neural dynamics in neurode
Dopaminergic Ventral Tegmental-Hippocampal Circuit Protectio	0.740	neuroscience	Circuit-level neural dynamics in neurode
Hippocampal-Cortical Transcriptomic Divergence Reveals Accel	0.680	Alzheimer disease	Allen Mouse Brain Aging Atlas: cross-age
Locus Coeruleus-Hippocampal Circuit Protection	0.653	neuroscience	Circuit-level neural dynamics in neurode
TDP-43 Cryptic Exon–Targeted ASOs to Restore Hippocampal Gam	0.577	neurodegeneration	RNA binding protein dysregulation across
LRP1-mediated synaptic uptake drives early entorhinal-hippoc	0.570	neurodegeneration	Which tau propagation mechanism predomin
Closed-loop transcranial focused ultrasound to restore hippo	0.564	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting entorh	0.564	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.564	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic restoration of hippocampal gamma oscillations vi	0.555	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.551	Alzheimer's disease	Circuit-level neural dynamics in neurode
Hippocampus ages transcriptionally faster than cerebellum, d	0.516	Alzheimer's disease	Allen Mouse Brain Aging Atlas: cross-age
Age-dependent downregulation of KPNA2 creates limbic neuron-	0.452	neurodegeneration	What mechanisms drive TDP-43 pathology s
HBOT at 2.0 ATA for 60 min, 5x/week for 6 weeks enhances hip	0.450	neurodegeneration	What are the optimal oxygen pressure, du

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (15)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Plant-based dietary patterns and Alzheimer's disease risk in multiethn	clinical	Alzheimer's disease and relate	0.950	0.00	human patients	proposed	N/A
Epigenetic clocks association with brain aging patterns in older women	exploratory	cognitive impairment and demen	0.900	0.00	human patients	proposed	N/A
SIRPα modulation in mouse models of Alzheimer's disease	validation	Alzheimer's disease	0.900	0.00	mouse models of Alzheimer's di	proposed	N/A
Tet2 modulation in Aβ42-injured mouse hippocampal neurons	exploratory	Alzheimer's disease	0.900	0.00	primary mouse hippocampal neur	proposed	N/A
Synaptic plasticity and protein expression analysis in mPFC	exploratory	insomnia-anxiety comorbidity	0.850	0.00	mPFC brain slices from PCPA-tr	proposed	N/A
Microglial SIRPα expression in human Alzheimer's disease tissue	exploratory	Alzheimer's disease	0.800	0.00	human brain tissue	proposed	N/A
Brain Connectivity-Targeted tACS Trial in Early AD	clinical	Alzheimer's Disease	0.509	0.50	human postmortem brain tissue	proposed	$520,000
s:** - Test whether HCN1 knockout specifically in EC layer II accelera	falsification	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$80,000
AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Positive Indiv	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$6,550,000
AD Combination Therapy Trial: Anti-Aβ + Anti-Tau	clinical	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$180,000
Biomarker-Guided Sequential Therapy Selection in Alzheimer's Disease	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
tACS Connectivity Trial in Early Alzheimer's	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Brain Connectivity-Targeted tACS Trial in Early AD	clinical	Alzheimer's Disease	0.400	0.50	mouse	proposed	$730,000
Cognitive Reserve Mechanisms in Alzheimer's Disease — Molecular Basis	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$6,550,000
Cholinergic System Dysfunction in DLB — Mechanisms and Therapeutic Res	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Complement C1q/C3-CR3 signaling pathway mediates abnormal microglial phagocytosi [PMID:38642614]	Han QQ, Shen SY, Liang LF, Chen XR, Yu J	Brain Behav Immun	2024	1
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704]	Zhang T, Xu D, Trefts E, Lv M, Inuzuka H	Science	2023	1
Anatomical and neurochemical profiles of somatostatin-positive neurons in the mo [PMID:41796787]	Tomioka R, Kobayashi K, Song WJ	Neuroscience	2026	0
Subtype-Specific Roles of Anterior Cingulate Cortex Neurons in Pain-Induced Soci [PMID:41799202]	Wan X, Yan Z, Zhang Z, Liu X, Yang D, Zh	Theranostics	2026	0
A comparative analysis of pig-to-rhesus corneal xenotransplantation with various [PMID:41928466]	Lee SH, Yoon CH, Choi HJ, Lee HJ, Kang H	Korean J Ophthalmol	2026	0
Epigenetically regulated pancreatic GABA-somatostatin signaling underlies gestat [PMID:41779871]	Zhu H, Luo S, Liu C, Cheng Y, Ren Z, Mo	Science translational medicine	2026	0
Therapeutic Potential of Somatostatin and Its Analogues in Alzheimer's Disease: [PMID:41854733]	Liu K, Zhang XY, Wang YT, Wang R, Jin RH	Molecular neurobiology	2026	0
Altered Expression of GABA-Related Genes in Schizophrenia: Insights from Meta-An [PMID:41788138]	Singer Y, Yitzhaky A, Hertzberg L	Alpha psychiatry	2026	0
Paracrine inhibition via G protein inwardly rectifying potassium channels regula [PMID:41824458]	Panzer JK, Lang AL, Levi NJ, Garcia PA,	Cell reports	2026	0
GADD45G operates as a pathological sensor orchestrating reactive gliosis and neu [PMID:40409253]	Shen T, Tai W, Jiang D, Ma S, Zhong X, Z	Neuron	2025	0
Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheime [PMID:41035073]	Castanho I, Naderi Yeganeh P, Boix CA, M	Molecular neurodegeneration	2025	0
The cholesterol 24-hydroxylase CYP46A1 promotes α-synuclein pathology in Parkins [PMID:39964974]	Dai L, Wang J, Meng L, Zhang X, Xiao T,	PLoS biology	2025	0
Molecular hallmarks of excitatory and inhibitory neuronal resilience and resista [PMID:39868232]	Castanho I, Yeganeh PN, Boix CA, Morgan	bioRxiv : the preprint server	2025	0
From stress to Alzheimer's: A circuit-based framework for prefrontal cognitive d [PMID:41115499]	Yi JH	Neuroscience letters	2025	0
Hippocampal Interneurons Shape Spatial Coding Alterations in Neurological Disord [PMID:40392508]	Ikebara JM, Jorge RS, Marinho LSR, Higa	Molecular neurobiology	2025	0
Somatostatin and the pathophysiology of Alzheimer's disease. [PMID:38484981]	Almeida VN	Ageing Res Rev	2024	0
Somatostatin and the pathophysiology of Alzheimer's disease. [PMID:38484981]	Almeida VN	Ageing research reviews	2024	0
Sterols and pentacyclic triterpenoids from nettle root: content and composition [PMID:36478201]	["Cegledi E", "Repaji\u0107 M", "Balbino	Journal of the science of food	2023	0
The association between the type of progesterone supplementation and miscarriage [PMID:37156908]	["Shaulov T", "Zanr\u00e9 N", "Phillips	Archives of gynecology and obs	2023	0
SHP2 inhibitors maintain TGFβ signalling through SMURF2 inhibition. [PMID:38102334]	["Lai X", "Lui S", "Lam H", "Adachi Y",	NPJ precision oncology	2023	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HIPPO in their description or question text

HIPPO

Understanding Entity Pages

Summary

Wiki Pages (1)

Hippo Signaling Pathway in Neurodegeneration

Pathway Diagram

Outgoing (414)

Incoming (229)

Targeting Hypotheses (30)

Mentioning Analyses (0)

Experiments (15)

Related Papers (20)

Debates (0)

Related Research

Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95 palmitoylation stab

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Gamma entrainment therapy to restore hippocampal-cortical synchrony

Optogenetic viral vector delivery via tFUS-mediated blood-brain barrier opening

Optogenetic restoration of hippocampal gamma oscillations via selective SST inte

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Real-time gamma-guided transcranial focused ultrasound targeting EC-II SST inter

Hippocampal CA3-CA1 circuit rescue via neurogenesis and synaptic preservation

Closed-loop transcranial focused ultrasound targeting CA1 PV interneurons with r

Closed-loop transcranial alternating current stimulation to restore hippocampal-

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Cholinergic Basal Forebrain-Hippocampal Circuit Protection

Dopaminergic Ventral Tegmental-Hippocampal Circuit Protection

Hippocampal-Cortical Transcriptomic Divergence Reveals Accelerated Neurodegenera

Locus Coeruleus-Hippocampal Circuit Protection