gene

TGFBI

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TGFBI: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

42Connections

0Hypotheses

0Analyses

22Outgoing

20Incoming

0Experiments

0Debates

Summary

Comprehensive page on TGFBI (Transforming Growth Factor Beta Induced Protein), an extracellular matrix protein implicated in Alzheimer's disease, corneal dystrophies, and cancer with roles in cell adhesion, integrin signaling, and neuroinflammation.

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🧬 Gene Info

Gene Symbol	TGFBI
Full Name	Transforming Growth Factor Beta Induced Protein
Chromosome	5q31.1
Function	is a secreted extracellular matrix (ECM) protein that plays crucial roles in cell adhesion, tissue development, and disease pathogenesis.
Molecular Weight	75 kDa
Amino Acids	683 aa
Exons	17
Pathways	TGF-β
UniProt ID	Q15582
NCBI Gene ID	7045
Ensembl ID	ENSG00000120708
OMIM	601692
GeneCards	TGFBI
Human Protein Atlas	TGFBI
Associated Diseases	Als, Ms, Schizophrenia
Interactions	CANCER, GENES
KG Connections	42 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TGFBI — AlphaFold Q15582 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TGFBI

gene · 1427 words

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Pathway Diagram

graph TD
    TGFBI["TGFBI"]
    Ms{"Ms"}
    TGFBI -->|"associated with"| Ms
    Schizophrenia{"Schizophrenia"}
    TGFBI -->|"associated with"| Schizophrenia
    Als{"Als"}
    TGFBI -->|"associated with"| Als
    neurodegeneration["neurodegeneration"]
    TGFBI -->|"implicated in"| neurodegeneration
    HCRTR2["HCRTR2"]
    HCRTR2 -->|"associated with"| TGFBI
    style TGFBI fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (22)

Target	Relation	Type	Str
Cancer	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Schizophrenia	associated_with	disease	0.65
Tumor	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Diabetes	biomarker_for	disease	0.65
Cancer	biomarker_for	disease	0.65
Nf-Κb	biomarker_for	pathway	0.60
Insulin	biomarker_for	protein	0.60
CD44	associated_with	gene	0.60
GJA1	associated_with	gene	0.60
PRDM1	regulates	gene	0.60
Nf-Κb	regulates	pathway	0.60
App	regulates	protein	0.60
HUB GENES	associated_with	gene	0.60
CANCER	regulates	gene	0.60
DIABETES MELLITUS	regulates	gene	0.60
Insulin	regulates	protein	0.60
PRDM1	protects_against	gene	0.50
RUNX2	associated_with	concept	0.50

Incoming (20)

Source	Relation	Type	Str
PRDM1	regulates	gene	0.60
GJA1	associated_with	gene	0.60
CD44	associated_with	gene	0.60
PRDM1	biomarker_for	gene	0.60
HCRTR2	associated_with	gene	0.60
GENES	associated_with	gene	0.60
INFLAMMATION	regulates	gene	0.60
INSULIN RESISTANCE	regulates	gene	0.60
NF-ΚB	regulates	gene	0.60
ALDH1A1	expressed_in	gene	0.60
CD63	expressed_in	gene	0.60
CLU	expressed_in	gene	0.60
KRT12	expressed_in	gene	0.60
RUNX2	associated_with	gene	0.60
CANCER	interacts_with	gene	0.50
GENES	interacts_with	gene	0.50
NF-ΚB	co_discussed	gene	0.50
GJA1	co_expressed_with	gene	0.50
PRDM1	co_expressed_with	gene	0.50
GJA1	co_discussed	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TGFBI in their description or question text

No additional research found