gene 1,313 words KG: CD44
Contents

CD44 - Cell Surface Glycoprotein

🧬 Gene Info
Gene SymbolCD44
Full NameCell Surface Glycoprotein
AliasesPage for CD44
Chromosome11p13
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight95 kDa
Amino Acids341 aa
Exons19
PathwaysNF-κB, TGF-β
NCBI Gene ID2115452
Ensembl IDENSG00000026508
GeneCardsCD44
Human Protein AtlasCD44
Associated DiseasesAging, Als, Alzheimer, Cardiac, dementia
InteractionsADAM10, AKT, ALS, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE
KG Connections747 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (23)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
Senescence-Activated NAD+ Depletion Rescue
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Microglial Purinergic Reprogramming
Score: 0.70
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
Glial Glycocalyx Remodeling Therapy
Score: 0.65
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
Pharmacological Enhancement of APOE4 Glycosylation
Score: 0.62
pg 1/2Next →

Related Analyses (7)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

See Also (13)

Apoptosis in Neurodegeneration
entity · KG edge: inhibits
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: therapeutic_target
ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: therapeutic_target
ACTB Gene
gene · KG edge: associated_with
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: activates

Knowledge Graph (12 edges)

FGF20 therapeutic_target CD44
BRG1 therapeutic_target CD44
NRCAM therapeutic_target CD44
NOTCH2 therapeutic_target CD44
EP300 therapeutic_target CD44
CTNNB1 therapeutic_target CD44
NEUROD1 therapeutic_target CD44
MYC therapeutic_target CD44
VEGFA therapeutic_target CD44
FOXM1 therapeutic_target CD44

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.