concept

NICOTINAMIDE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NICOTINAMIDE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

191Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	NICOTINAMIDE
Key Genes/Proteins	ABCA7, AMPK, AMYLOID, APP, ATG5, ATG7
Related Diseases	AGING, ALZHEIMER, ALZHEIMER'S DISEASE, ATP, AUTOPHAGY

Pathway Diagram

graph TD
    NICOTINAMIDE["NICOTINAMIDE"]
    NICOTINAMIDE -->|"regulates"| SIRT1["SIRT1"]
    NICOTINAMIDE -->|"implicated in"| OBESITY["OBESITY"]
    NICOTINAMIDE -->|"inhibits"| SLC7A11["SLC7A11"]
    NICOTINAMIDE -->|"inhibits"| ROS["ROS"]
    NICOTINAMIDE -->|"interacts"| STEM_CELLS["STEM CELLS"]
    NICOTINAMIDE -->|"activates"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    NEURON["NEURON"] -->|"inhibits"| NICOTINAMIDE
    GSH["GSH"] -->|"inhibits"| NICOTINAMIDE
    FERROPTOSIS["FERROPTOSIS"] -->|"inhibits"| NICOTINAMIDE
    INFLAMMATION["INFLAMMATION"] -->|"causes"| NICOTINAMIDE
    B_CELLS["B CELLS"] -->|"activates"| NICOTINAMIDE
    AGING["AGING"] -->|"implicated in"| NICOTINAMIDE
    GPX4["GPX4"] -->|"inhibits"| NICOTINAMIDE
    CATALASE["CATALASE"] -->|"target for"| NICOTINAMIDE

Outgoing (114)

Target	Relation	Type	Str
SIRT1	targets	gene	0.85
NAD+ metabolism	modulates	pathway	0.85
NAD	targets	gene	0.85
mitochondrial function	modulates	pathway	0.85
NAMPT	targets	gene	0.75
ALZHEIMER	causes	disease	0.70
AUTOPHAGY	associated_with	phenotype	0.70
AUTOPHAGY	activates	phenotype	0.70
ALZHEIMER'S DISEASE	inhibits	disease	0.70
AGING	treats	phenotype	0.70
SIRT1	activates	gene	0.70
NEURODEGENERATION	exacerbates	phenotype	0.70
SIRT1	treats	gene	0.70
UNFOLDED PROTEIN RESPONSE	activates	pathway	0.70
SIRT3	treats	gene	0.70
MITOPHAGY	degrades	phenotype	0.65
AMPK	targets	gene	0.65
OXIDATIVE STRESS	inhibits	phenotype	0.65
OBESITY	associated_with	disease	0.65
OXIDATIVE STRESS	interacts_with	phenotype	0.65
METFORMIN	treats	drug	0.65
METFORMIN	activates	drug	0.65
CELL DEATH	associated_with	phenotype	0.65
INFLAMMATION	associated_with	phenotype	0.65
oxidative stress response	modulates	pathway	0.65
ubiquitin-proteasome	modulates	pathway	0.65
CLOCK	targets	gene	0.65
BMAL1	targets	gene	0.65
circadian regulation	modulates	pathway	0.65
autophagy pathway	modulates	pathway	0.65
SUBSTANTIA NIGRA	protects_against	brain_region	0.65
SUBSTANTIA NIGRA	inhibits	brain_region	0.65
BREAST CANCER	inhibits	disease	0.65
MACROPHAGES	activates	cell_type	0.65
NRF2	activates	gene	0.65
AUTOPHAGY	inhibits	phenotype	0.65
NRF2	inhibits	gene	0.65
TET2	targets	gene	0.55
ATP	participates_in	phenotype	0.55
SIRT6	targets	gene	0.55
NRF1	targets	gene	0.55
APP	targets	gene	0.55
ATP	targets	gene	0.55
CSF1R	targets	gene	0.55
neuroinflammation	treats	disease	0.55
Alzheimer's disease	treats	disease	0.55
PS1	targets	gene	0.55
PINK1	targets	gene	0.55
PRKN	targets	gene	0.55
HDAC3	targets	gene	0.55

Incoming (77)

Source	Relation	Type	Str
AGING	inhibits	phenotype	0.70
HDAC3	inhibits	gene	0.70
CSF1R	inhibits	gene	0.70
NAD	inhibits	gene	0.65
NAD	stabilizes	gene	0.65
AMYLOID	treats	protein	0.65
MACROPHAGE	expressed_in	cell_type	0.65
NAD	interacts_with	gene	0.65
KYNURENINE	activates	phenotype	0.65
NEURONS	treats	cell_type	0.65
NAD	mediates	gene	0.65
NAD	promotes	gene	0.65
NAD	contributes_to	gene	0.65
CD38	regulates	gene	0.65
NAD	regulates	gene	0.65
NAD	treats	gene	0.65
CD38	activates	gene	0.65
FERROPTOSIS	regulates	phenotype	0.65
FIBROBLASTS	associated_with	cell_type	0.65
CHOLESTEROL	causes	phenotype	0.65
HDAC3	synergizes_with	gene	0.60
METFORMIN	synergizes_with	drug	0.60
CEREBROSPINAL FLUID	associated_with	phenotype	0.50
NEURON	inhibits	cell_type	0.50
GSH	inhibits	gene	0.50
FERROPTOSIS	inhibits	process	0.50
PARKINSON'S DISEASE	associated_with	disease	0.50
UNFOLDED PROTEIN RESPONSE	associated_with	pathway	0.50
PROTEIN AGGREGATION	associated_with	phenotype	0.50
NEUROINFLAMMATION	associated_with	phenotype	0.50
HISTONE ACETYLATION	associated_with	phenotype	0.50
DOPAMINERGIC NEURONS	associated_with	cell_type	0.50
BREAST CANCER	associated_with	disease	0.50
NEURODEGENERATION	associated_with	phenotype	0.50
SUBSTANTIA NIGRA	associated_with	brain_region	0.50
INFLAMMATION	associated_with	phenotype	0.45
MACROPHAGES	associated_with	cell_type	0.45
NLRP3 INFLAMMASOME	associated_with	pathway	0.45
ATP	associated_with	phenotype	0.45
CELL DEATH	associated_with	phenotype	0.45
KYNURENINE PATHWAY	associated_with	pathway	0.45
AUTOPHAGY	associated_with	phenotype	0.45
GPX4	associated_with	gene	0.45
NEURONS	associated_with	cell_type	0.45
AMYLOID	associated_with	protein	0.45
OXIDATIVE STRESS	associated_with	phenotype	0.45
APP	associated_with	gene	0.45
MELATONIN	associated_with	drug	0.45
MITOPHAGY	associated_with	phenotype	0.45
ENERGY METABOLISM	associated_with	phenotype	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NICOTINAMIDE in their description or question text

No additional research found