Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PDGF-BB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Hepatic Stellate Cell Activation | activates | process | 0.95 |
| HSC activation | causes | phenotype | 0.90 |
| catalase | upregulates | protein | 0.80 |
| superoxide dismutase | upregulates | protein | 0.80 |
| glutathione peroxidase | upregulates | protein | 0.80 |
| neuroglobin | upregulates | protein | 0.80 |
| astrocytes | protects_against | cell_type | 0.80 |
| PDGFRβ | activates | protein | 0.25 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| PDGF-BB/PDGFRβ/STAT3 Paracrine Signaling Axis Mediates Aβ-In | 0.618 | neurodegeneration | How do perivascular cells specifically r |
| Platelet-Derived PDGF-BB Primes VSMCs for P2RY12 Upregulatio | 0.480 | neurodegeneration | What determines P2RY12 receptor expressi |
| Cerebral VSMC foam cells induce pericyte detachment via PDGF | 0.473 | neurodegeneration | How does P2RY12-mediated VSMC dysfunctio |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-26 | 8 hypotheses Top: 0.735
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning PDGF-BB in their description or question text
No additional research found