| Gene Symbol | BIP |
| Full Name | Binding Immunoglobulin Protein |
| Aliases | HSPA5/GRP78 |
| Protein Type | Protein |
| Function | De Novo Folding: Binds nascent polypeptide chains as they enter the ER via the Sec61 translocon |
| Subcellular Localization | the ER lumen. Its primary functions include: |
| Molecular Weight | 78 kDa |
| Amino Acids | 654 aa |
| Pathways | Autophagy, Mapk, Mtor, Pi3K/Akt, Unfolded Protein Response |
| UniProt ID | P11021 |
| GeneCards | BIP |
| Human Protein Atlas | BIP |
| Protein folding assistance | BIP binds to nascent polypeptides and ensures proper folding by preventing aggregation |
| ER quality control | BIP monitors protein folding status and targets misfolded proteins for degradation |
| UPR regulation | BIP acts as the primary sensor for ER stress, controlling activation of three UPR branches: |
| Associated Diseases | Tumor |
| Interactions | ACETYL-COA, AKT, AND, ANXIETY, APOPTOSIS, ARC |
| KG Connections | 181 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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