ATP
Entity Detail — Knowledge Graph Node
Understanding Entity Pages
This page aggregates everything SciDEX knows about ATP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Summary
ATP is a protein involved in neurodegeneration research. Key relationships include: activates, interacts with, regulates. Associated with AD, ADH, ALI. Connected to 1217 entities in the SciDEX knowledge graph.
AI-generated illustration · click image to enlarge
Regenerate portrait ↻| Gene Symbol | ATP |
| Chromosome | 7q36.1 |
| Subcellular Localization | both the cell body and central and peripheral nerve terminals, where they detect ATP released from damaged cells, inflam |
| Pathways | Purinergic Signaling |
| GeneCards | ATP |
| Human Protein Atlas | ATP |
| Associated Diseases | AD, ADH, Aging, ALI, Als |
| Known Drugs/Compounds | EMPAGLIFLOZIN, ENERGY_STRESS, metformin, METFORMIN, nicotinamide, rapamycin |
| Interactions | ABCA1, ABCA4, ABCA7, ABCB1, ABCD1, ABCD3 |
| KG Connections | 2732 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Wiki Pages (21)
Knowledge base pages for this entity
ATP P2X3 Receptor Neurons
cell · 1900 wordsATP5F1 — ATP Synthase F1 Subunit Beta
gene · 4040 wordsATP13A2 Lysosomal Dysfunction Pathway in Parkinson's Disease
mechanism · 3852 wordsATP13A2 — ATPase Cation Transporting 13A2
gene · 3222 wordsABCD1 — ATP Binding Cassette Subfamily D Member 1
gene · 2787 wordsATP13A9 Gene - ATPase 13A9
gene · 2677 wordsPathway Diagram
graph TD
ATP["ATP"] -->|"activates"| NLRP3["NLRP3"]
ATP["ATP"] -->|"activates"| coenzyme_A["coenzyme A"]
ATP["ATP"] -->|"regulates"| Ischemia["Ischemia"]
ATP["ATP"] -->|"activates"| Metabolic_Syndrome["Metabolic Syndrome"]
ATP["ATP"] -->|"interacts"| ALS["ALS"]
ATP["ATP"] -.->|"inhibits"| Atherosclerosis["Atherosclerosis"]
CGAS["CGAS"] -->|"interacts"| ATP["ATP"]
ENERGY_STRESS["ENERGY_STRESS"] -.->|"inhibits"| ATP["ATP"]
MTOR["MTOR"] -->|"regulates"| ATP["ATP"]
MYC["MYC"] -->|"regulates"| ATP["ATP"]
style ATP fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0Outgoing (1810)
| Target | Relation | Type | Str |
|---|---|---|---|
| ATP | encodes | protein | 0.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| Mitophagy | activates | pathway | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Als | associated_with | disease | 1.00 |
| Infection | activates | disease | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| Oxidative Phosphorylation | associated_with | pathway | 1.00 |
| Glycolysis | associated_with | pathway | 1.00 |
| Als | regulates | disease | 1.00 |
| Mitochondrial Function | activates | pathway | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Glycolysis | activates | pathway | 1.00 |
| Cancer | activates | disease | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Mtor | activates | pathway | 1.00 |
| Cardiovascular | activates | disease | 1.00 |
| Als | inhibits | disease | 1.00 |
| CANCER | activates | gene | 1.00 |
| Oxidative Phosphorylation | activates | pathway | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Stroke | activates | disease | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| Diabetes | activates | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| Obesity | activates | disease | 1.00 |
| Autophagy | inhibits | pathway | 1.00 |
| Mtor | inhibits | pathway | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| Cardiovascular | therapeutic_target | disease | 0.95 |
| Parkinson | activates | disease | 0.95 |
| Cardiac | activates | disease | 0.95 |
| Inflammation | regulates | disease | 0.95 |
| Tumor | associated_with | disease | 0.95 |
| Cardiovascular | regulates | disease | 0.95 |
| Inflammation | inhibits | disease | 0.95 |
| oxidative stress response | participates_in | pathway | 0.90 |
| apoptosis pathway | participates_in | pathway | 0.90 |
| NF-kB signaling | participates_in | pathway | 0.90 |
| purinergic receptor | associated_with | receptor | 0.90 |
| NLRP3 Inflammasome Activation | activates | process | 0.90 |
| neural stem cells | activates | cell_type | 0.90 |
| purinergic receptor | activates | receptor | 0.90 |
| Immune Response | regulates | pathway | 0.90 |
Incoming (927)
| Source | Relation | Type | Str |
|---|---|---|---|
| ATP | encodes | gene | 0.00 |
| CANCER | activates | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| DNA | activates | gene | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | activates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| MITOPHAGY | activates | gene | 1.00 |
| AMPK | activates | gene | 1.00 |
| MITOCHONDRIA | activates | gene | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| GENES | activates | gene | 1.00 |
| AUTOPHAGY | inhibits | gene | 1.00 |
| ROS | activates | gene | 1.00 |
| CANCER | inhibits | gene | 1.00 |
| PINK1 | activates | gene | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | therapeutic_target | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | activates | gene | 1.00 |
| 34068881 | triggers | paper | 0.90 |
| 34068881 | serves as | paper | 0.90 |
| CGAS | interacts_with | protein | 0.90 |
| MITOCHONDRIA | causes | gene | 0.90 |
| AMPK | inhibits | gene | 0.90 |
| MITOCHONDRIA | inhibits | gene | 0.90 |
| TFAM | activates | gene | 0.90 |
| INFLAMMATION | inhibits | gene | 0.90 |
| MTORC1 | activates | gene | 0.90 |
| MITOCHONDRIA | associated_with | gene | 0.90 |
| MITOCHONDRIAL DYSFUNCTION | regulates | gene | 0.90 |
| INFLAMMATION | regulates | gene | 0.90 |
| ALZHEIMER'S DISEASE | activates | gene | 0.90 |
| INFLAMMATION | activates | gene | 0.90 |
| ROS | inhibits | gene | 0.90 |
| GENES | regulates | gene | 0.90 |
| Mifepristone | upregulates | drug | 0.80 |
| ATG | activates | gene | 0.80 |
| ABCA7 | interacts_with | gene | 0.80 |
| APOPTOSIS | therapeutic_target | gene | 0.80 |
| NEURODEGENERATION | therapeutic_target | gene | 0.80 |
| MITOCHONDRIAL DYSFUNCTION | inhibits | gene | 0.80 |
| DNA | regulates | gene | 0.80 |
| DIABETES MELLITUS | activates | gene | 0.80 |
| DNA | interacts_with | gene | 0.80 |
| MITOCHONDRIA | regulates | gene | 0.80 |
| OXIDATIVE STRESS | inhibits | gene | 0.80 |
| AKT | activates | gene | 0.80 |
| NEURODEGENERATIVE DISEASES | therapeutic_target | gene | 0.80 |
| ASTROCYTES | activates | gene | 0.80 |
| ACETYL-COA | activates | gene | 0.80 |
Targeting Hypotheses (11)
Hypotheses where this entity is a therapeutic target
Mentioning Analyses (1)
Scientific analyses that reference this entity
Does tau aggregation specifically cause PS externalization in vesicles independe
neurodegeneration | 2026-04-11 | 0 hypotheses
Experiments (1)
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Synaptic Mitochondrial Resilience Enhancement for Parkinson's Disease | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,730,000 |
Related Papers (0)
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Debates (1)
Multi-agent debates referencing this entity
Related Research
Hypotheses and analyses mentioning ATP in their description or question text
Synaptic Mitochondrial Proteostasis Collapse Disrupts ATP-Demand Coupling at Act
Score: 0.455 · neurodegeneration · 2026-04-27
Age-dependent oxidation and deamidation of synaptic mitochondrial proteins (including VDAC1, CypD/PPID, and MICOS comple
Temporal Gating Through HSP70 ATPase Cycle Manipulation
Score: 0.455 · drug discovery · 2026-04-27
Compounds that extend HSP70's ATPase cycle specifically when bound to tau substrates, trapping tau in non-productive cha
ATP Depletion-Responsive Penetrating Nanobodies
Score: 0.455 · molecular biology · 2026-04-27
Nanobodies engineered to selectively penetrate membranes in ATP-depleted environments could target tau-containing vesicl
P2X7 Receptor Antagonism to Block ATP-Induced Microglial Pyroptosis
Score: 0.454 · immunomics · 2026-04-25
P2X7 Receptor Antagonism to Block ATP-Induced Microglial Pyroptosis
J-protein co-chaperone repertoire drives ATP-independent disaggregation through
Score: 0.380 · protein biochemistry · 2026-04-26
The J-protein co-chaperone system operates through a novel ATP-independent disaggregation mechanism that localizes patho
Kinetic Threshold Model of Chaperone-CHIP Coupling: ATP Cycle Velocity Determine
Score: 0.380 · protein folding · 2026-04-27
This hypothesis proposes that the efficiency of pathological protein clearance is governed by the kinetic coupling betwe