gene 3,222 words KG: ATP13A2
Contents

ATP13A2 — ATPase Cation Transporting 13A2

🧬 Gene Info
Gene SymbolATP13A2
Full NameATPase Cation Transporting 13A2 (PARK9)
AliasesATPase Cation Transporting 13A2
Chromosome1p36.13
Protein TypeProtein
Functionis a member of the P-type ATPase family that functions as a lysosomal cation transporter, primarily pumping manganese and other cations across the lysosomal membrane[@ramirez2006].
Primary ExpressionSubstantia nigra, Basal ganglia, Cerebral cortex
Subcellular LocalizationLysosomes, Late endosomes
Molecular Weight446 kDa
Amino Acids978 aa
PathwaysAutophagy
UniProt IDQ9BYU8
Ensembl IDENSG00000159363
GeneCardsATP13A2
Human Protein AtlasATP13A2
Associated Diseasesaging, Als, Alzheimer, Amyotrophic Lateral Sclerosis
InteractionsAlpha-Synuclein, ALS, AMYLOID, AND, ATXN2, CP
KG Connections427 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (12)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76

Related Analyses (6)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed

Related Experiments (6)

Experiment: Multi-Ethnic PD GWAS
clinical · proposed · Score: 0.40
Synaptic Mitochondrial Resilience Enhancement for Parkinson'
validation · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Validate Mitochondria-Lysosome Contact Site Dysfunction in P
validation · proposed · Score: 0.40
Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.40

See Also (9)

Amyotrophic Lateral Sclerosis
redirect · KG edge: causes
ABCA7 (Redirect)
redirect · KG edge: associated_with
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_with
ATP1A3 Gene - Sodium-Potassium ATPase Alpha 3
gene · KG edge: associated_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: associated_with

Knowledge Graph (12 edges)

PINK1 therapeutic_target ATP13A2
ATP13A2 therapeutic_target GAIN
ATP13A2 therapeutic_target LRRK2
ATP13A2 therapeutic_target PRKN
LRRK2 therapeutic_target ATP13A2
ATP13A2 therapeutic_target PINK1
PRKN therapeutic_target ATP13A2
ATP13A2 associated_with LRRK2
ATP13A2 associated_with PINK1
ATP13A2 associated_with PRKN

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