gene 2,588 words KG: ent-gene-0cd1e1e5
Contents

ABCA7 (ATP-Binding Cassette Transporter A7)

🧬 Gene Info
Gene SymbolABCA7
FunctionABCA7 encodes ATP-binding cassette transporter A7, a member of the ABC transporter family.
Primary Expressionimmune cells and the brain, where it plays important roles in lipid transport and cellular homeostasis
PathwaysCholesterol, Glycolysis, Immune Response, Lipid Metabolism, Nf-Κb
Ensembl IDENSG00000064687
GeneCardsABCA7
Human Protein AtlasABCA7
Lipid effluxMediates transport of lipids to apolipoproteins
Phospholipid transportTransfers phospholipids across cellular membranes
Cholesterol homeostasisRegulates cellular cholesterol levels
Immune functionModulates macrophage and microglial responses
PhagocytosisInvolved in cellular clearance mechanisms
Associated Diseasesage-related macular degeneration, Als, Alzheimer, alzheimer_disease, Alzheimer's disease
InteractionsABCA1, ABCA4, ABCG1, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK
KG Connections580 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (22)

Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Membrane Cholesterol Gradient Modulators
Score: 0.71
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.75
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Transglutaminase-2 Cross-Linking Inhibition Strategy
Score: 0.64
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62
TREM2-Dependent Microglial Senescence Transition
Score: 0.58
APOE-TREM2 Interaction Modulation
Score: 0.74
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Related Analyses (5)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (4)

ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_with
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates

Knowledge Graph (7 edges)

35034901 has stronger effect size than ent-gene-0cd1e1e5
35034901 is involved in ent-gene-0cd1e1e5
31690660 regulates ent-gene-0cd1e1e5
31690660 is involved in maintaining ent-gene-0cd1e1e5
ent-gene-0cd1e1e5 has_risk_variant rs3764650
ent-gene-0cd1e1e5 participates_in_pathway R-HSA-1369062
30906402 is associated with ent-gene-0cd1e1e5

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