protein 1,622 words KG: ATP13A2
Contents

ATP13A2 Protein (PARK9)

🔬 Protein Info
Gene SymbolATP13A2
Full NameATPase Cation Transporting 13A2
Chromosome1p36.13
Protein TypeProtein
Functionis a member of the P-type ATPase family that functions as a lysosomal cation transporter, primarily pumping manganese and other cations across the lysosomal membrane[@ramirez2006].
Primary ExpressionSubstantia nigra, Basal ganglia, Cerebral cortex
Subcellular LocalizationLysosomes, Late endosomes
Molecular Weight446 kDa
Amino Acids978 aa
PathwaysAutophagy
UniProt IDQ9BYU8
Ensembl IDENSG00000159363
GeneCardsATP13A2
Human Protein AtlasATP13A2
Associated Diseasesaging, Als, Alzheimer, Amyotrophic Lateral Sclerosis
InteractionsAlpha-Synuclein, ALS, AMYLOID, AND, ATXN2, CP
KG Connections423 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (15)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Lysosomal Positioning Dynamics Modulation
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51

Related Analyses (10)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived

Related Experiments (2)

Experiment: Multi-Ethnic PD GWAS
clinical · proposed · Score: 0.40
Synaptic Mitochondrial Resilience Enhancement for Parkinson'
validation · proposed · Score: 0.40

See Also (8)

Amyotrophic Lateral Sclerosis
redirect · KG edge: causes
ABCA7 (Redirect)
redirect · KG edge: associated_with
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with

Knowledge Graph (12 edges)

PINK1 therapeutic_target ATP13A2
ATP13A2 therapeutic_target GAIN
ATP13A2 therapeutic_target LRRK2
ATP13A2 therapeutic_target PRKN
LRRK2 therapeutic_target ATP13A2
ATP13A2 therapeutic_target PINK1
PRKN therapeutic_target ATP13A2
ATP13A2 associated_with LRRK2
ATP13A2 associated_with PINK1
ATP13A2 associated_with PRKN

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