concept

PURINERGIC RECEPTOR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PURINERGIC RECEPTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

65Connections

1Hypotheses

0Analyses

20Outgoing

45Incoming

0Experiments

0Debates

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💡 Concept Info

Name	PURINERGIC RECEPTOR

Pathway Diagram

graph TD
    PURINERGIC_RECEPTOR[PURINERGIC RECEPTOR]
    PURINERGIC_RECEPTOR -->|expressed in| microglia[microglia]
    PURINERGIC_RECEPTOR -->|expressed in| neurons[neurons]
    PURINERGIC_RECEPTOR -->|activates| purinergic_signaling[purinergic signaling]
    PURINERGIC_RECEPTOR -->|expressed in| astrocytes[astrocytes]
    PURINERGIC_RECEPTOR -->|activates| pyroptosis[pyroptosis]
    PURINERGIC_RECEPTOR -->|binds| adenosine[adenosine]
    PURINERGIC_RECEPTOR -->|expressed in| blood_brain_barrier[blood-brain barrier]
    PURINERGIC_RECEPTOR -->|expressed in| neural_stem_cells[neural stem cells]
    PURINERGIC_RECEPTOR -->|activates| unfolded_protein_response[unfolded protein response]
    PURINERGIC_RECEPTOR -->|expressed in| macrophages[macrophages]
    neuroinflammation[neuroinflammation] -->|involves| PURINERGIC_RECEPTOR
    neurodegeneration[neurodegeneration] -->|involves| PURINERGIC_RECEPTOR
    ATP[ATP] -->|implicated in| PURINERGIC_RECEPTOR
    Alzheimer_s_disease[Alzheimer's disease] -->|involves| PURINERGIC_RECEPTOR
    NLRP3[NLRP3] -->|inhibits| PURINERGIC_RECEPTOR
    depression[depression] -->|involves| PURINERGIC_RECEPTOR

Outgoing (20)

Target	Relation	Type	Str
neurons	expressed_in	cell_type	0.90
microglia	expressed_in	cell_type	0.90
astrocytes	expressed_in	cell_type	0.80
pyroptosis	activates	pathway	0.80
purinergic signaling	activates	pathway	0.80
blood-brain barrier	expressed_in	brain_region	0.70
neural stem cells	expressed_in	cell_type	0.70
adenosine	binds	neurotransmitter	0.70
unfolded protein response	activates	pathway	0.70
macrophages	expressed_in	cell_type	0.70
oligodendrocytes	expressed_in	cell_type	0.60
serotonin	binds	neurotransmitter	0.60
interneurons	expressed_in	cell_type	0.60
satellite glial cells	expressed_in	cell_type	0.60
cerebral cortex	expressed_in	brain_region	0.60
NF-kB signaling	activates	pathway	0.60
GABAergic neurons	expressed_in	cell_type	0.60
hippocampus	expressed_in	brain_region	0.60
synaptic plasticity	activates	pathway	0.60
cortex	expressed_in	brain_region	0.60

Incoming (45)

Source	Relation	Type	Str
neuroinflammation	involves	disease	0.90
ATP	activates	gene	0.90
neurodegeneration	involves	disease	0.90
ATP	associated_with	gene	0.90
Alzheimer's disease	involves	disease	0.90
ATP	regulates	gene	0.80
ATP	expressed_in	gene	0.80
NLRP3	inhibits	gene	0.80
NLRP3	activates	gene	0.70
multiple sclerosis	involves	disease	0.70
ATP	inhibits	gene	0.70
epilepsy	involves	disease	0.70
NLRP3	regulates	gene	0.70
depression	involves	disease	0.70
aspirin	activates	compound	0.60
aspirin	inhibits	compound	0.60
NLRP3	associated_with	gene	0.60
diabetes	involves	disease	0.60
P2RY12	regulates	gene	0.60
GPR109A	associated_with	gene	0.60
CMKLR1	associated_with	gene	0.60
ALS	regulates	gene	0.60
RNA	regulates	gene	0.60
RNA	inhibits	gene	0.60
RNA	associated_with	gene	0.60
NLRP3	causes	gene	0.60
HDAC3	activates	gene	0.60
RNA	activates	gene	0.60
HDAC3	inhibits	gene	0.60
ATP	interacts_with	gene	0.60
GSDMD	activates	gene	0.60
ATP	causes	gene	0.60
APP	inhibits	gene	0.60
APP	regulates	gene	0.60
APP	treats	gene	0.60
SOD1	activates	gene	0.60
SOD1	regulates	gene	0.60
GSDMD	regulates	gene	0.60
GSDMD	promotes	gene	0.60
GSDMD	interacts_with	gene	0.60
NLRP3	interacts_with	gene	0.60
GSDMD	expressed_in	gene	0.60
NLRP3	expressed_in	gene	0.60
ALS	activates	gene	0.60
ALS	involves	disease	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
P2RY12/P2RY13 Purinergic Receptor Metabolic Rewiring	0.490	neuroinflammation	What molecular mechanisms mediate SPP1-i

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PURINERGIC RECEPTOR in their description or question text

No additional research found