gene

IRF7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IRF7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

100Connections

0Hypotheses

0Analyses

50Outgoing

17Incoming

0Experiments

0Debates

Summary

IRF7 is a gene implicated in neurodegeneration research. Key relationships include: activates, expressed in, regulates. Associated with Cancer, Carcinoma, Inflammation. Connected to 35 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	IRF7
Chromosome	11p15.5
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	55 kDa
Amino Acids	503 aa
Exons	9
Pathways	Immune Response, Inflammasome, Jak-Stat, Pyroptosis
NCBI Gene ID	3665
GeneCards	IRF7
Human Protein Atlas	IRF7
Associated Diseases	neurodegeneration
Interactions	AGING, ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOE, BRAIN INFLAMMATION
KG Connections	100 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

IRF7 Gene

gene · 542 words

→

IRF7 Protein

protein · 1242 words

→

Pathway Diagram

graph TD
    IRF7["IRF7"]
    Carcinoma{"Carcinoma"}
    IRF7 -->|"activates"| Carcinoma
    Cancer{"Cancer"}
    IRF7 -->|"activates"| Cancer
    Tumor{"Tumor"}
    IRF7 -->|"activates"| Tumor
    Inflammation{"Inflammation"}
    IRF7 -->|"activates"| Inflammation
    Ms{"Ms"}
    IRF7 -->|"expressed in"| Ms
    INFLAMMATION["INFLAMMATION"]
    IRF7 -->|"activates"| INFLAMMATION
    CANCER["CANCER"]
    IRF7 -->|"activates"| CANCER
    STING["STING"]
    IRF7 -->|"regulates"| STING
    CGAS["CGAS"]
    IRF7 -->|"regulates"| CGAS
    NF__B["NF-KappaB"]
    IRF7 -->|"expressed in"| NF__B
    FERROPTOSIS["FERROPTOSIS"]
    IRF7 -->|"expressed in"| FERROPTOSIS
    PPARGC1A["PPARGC1A"]
    IRF7 -->|"expressed in"| PPARGC1A
    RPS18["RPS18"]
    RPS18 -->|"regulates"| IRF7
    JAK2["JAK2"]
    JAK2 -->|"activates"| IRF7
    RELA["RELA"]
    RELA -->|"expressed in"| IRF7
    MYC["MYC"]
    MYC -->|"expressed in"| IRF7
    SP1["SP1"]
    SP1 -->|"expressed in"| IRF7
    style IRF7 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (83)

Target	Relation	Type	Str
Inflammation	activates	disease	0.75
INFLAMMATION	activates	gene	0.70
Ms	expressed_in	disease	0.65
Pyroptosis	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
Carcinoma	activates	disease	0.65
Als	inhibits	disease	0.65
Depression	activates	disease	0.65
Alzheimer	activates	disease	0.65
Aging	activates	disease	0.65
Als	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Dementia	activates	disease	0.65
CSF1R	activates	gene	0.60
IL-6	activates	gene	0.60
DEMENTIA	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
GENES	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
CYTOKINES	activates	gene	0.60
IFN	activates	gene	0.60
MICROGLIA ACTIVATION	activates	gene	0.60
BRAIN INFLAMMATION	activates	gene	0.60
Immune Response	activates	pathway	0.60
STING	expressed_in	gene	0.60
Inflammasome	activates	pathway	0.60
IRF3	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
PTEN	activates	gene	0.60
CD68	expressed_in	gene	0.60
IFNAR1	activates	gene	0.60
STING	activates	gene	0.60
APOE	activates	gene	0.60
IRF3	activates	gene	0.60
ISG15	associated_with	gene	0.60
FGF10	inhibits	gene	0.60
CANCER	activates	gene	0.60
NF-ΚB	expressed_in	gene	0.60
FERROPTOSIS	expressed_in	gene	0.60
Ferroptosis	expressed_in	pathway	0.60
Nf-Κb	expressed_in	pathway	0.60
Oxidative Phosphorylation	expressed_in	pathway	0.60
Interferon	activates	protein	0.60
PARKINSON	regulates	gene	0.60
PYROPTOSIS	regulates	gene	0.60
STING	regulates	gene	0.60
Inflammasome	regulates	pathway	0.60
CGAS	regulates	gene	0.60

Incoming (17)

Source	Relation	Type	Str
RPS18	regulates	gene	0.80
RELA	expressed_in	gene	0.60
MYC	expressed_in	gene	0.60
SP1	expressed_in	gene	0.60
TLR4	regulates	gene	0.60
PYROPTOSIS	activates	gene	0.60
AGING	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
TNF-Α	activates	gene	0.60
MICROGLIA	activates	gene	0.60
JAK2	activates	gene	0.60
CGAS-STING	activates	gene	0.60
CGAS	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
CYTOKINES	inhibits	gene	0.60
DEPRESSION	activates	gene	0.60
CCL2	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IRF7 in their description or question text

No additional research found