concept

RUNX2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RUNX2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

248Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

RUNX2 is a concept in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with ALS, Aging, Als. Connected to 117 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	RUNX2
Key Genes/Proteins	AGING, AKT, AMPK, AND, ANGPT1, APOPTOSIS
Related Diseases	Aging, Als, ALS, aortic valve calcification
Related Pathways	Akt, Angiogenesis, Apoptosis

Pathway Diagram

graph TD
    RUNX2["RUNX2"]
    RUNX2 -->|"activates"| Als["Als"]
    RUNX2 -->|"activates"| Arthritis["Arthritis"]
    RUNX2 -->|"expressed in"| Aging["Aging"]
    RUNX2 -->|"activates"| Ms["Ms"]
    RUNX2 -->|"activates"| ALS["ALS"]
    RUNX2 -->|"activates"| PDGFRB["PDGFRB"]
    PRKCH["PRKCH"] -->|"regulates"| RUNX2
    PIEZO1["PIEZO1"] -->|"activates"| RUNX2
    VEGFB["VEGFB"] -->|"activates"| RUNX2
    VEGF["VEGF"] -->|"activates"| RUNX2
    FGF2["FGF2"] -->|"activates"| RUNX2
    YAP["YAP"] -->|"activates"| RUNX2
    GLS1["GLS1"] -->|"activates"| RUNX2
    RANK["RANK"] -->|"regulates"| RUNX2
    RANKL["RANKL"] -->|"regulates"| RUNX2
    ANGPT1["ANGPT1"] -->|"activates"| RUNX2

Outgoing (150)

Target	Relation	Type	Str
Osteogenesis	promotes	process	0.85
aortic valve calcification	promotes	phenotype	0.85
Osteogenic Differentiation	involved_in	process	0.85
Als	regulates	disease	0.75
Cancer	regulates	disease	0.75
VEGF	activates	gene	0.70
CYTOKINES	regulates	gene	0.70
CANCER	regulates	gene	0.70
Tgf-Β	regulates	pathway	0.70
Hedgehog	regulates	pathway	0.70
Notch	regulates	pathway	0.70
GENES	activates	gene	0.70
Wnt	regulates	pathway	0.70
PIEZO1	activates	gene	0.70
Als	therapeutic_target	disease	0.65
Autoimmune	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
Tumor	regulates	disease	0.65
Prostate Cancer	regulates	disease	0.65
ALS	activates	disease	0.65
Inflammation	regulates	disease	0.65
Cancer	biomarker_for	disease	0.65
Diabetes	biomarker_for	disease	0.65
Aging	expressed_in	disease	0.65
Als	associated_with	disease	0.65
Diabetes	regulates	disease	0.65
ALS	regulates	disease	0.65
Arthritis	activates	disease	0.65
Ms	expressed_in	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65
Cardiovascular	inhibits	disease	0.65
Ms	activates	disease	0.65
Als	activates	disease	0.65
Mitophagy	inhibits	pathway	0.60
Nf-Κb	inhibits	pathway	0.60
PI3K	activates	gene	0.60
AKT	activates	gene	0.60
Pi3K/Akt	activates	pathway	0.60
APOPTOSIS	therapeutic_target	gene	0.60
BCL2	therapeutic_target	gene	0.60
CASPASE3	therapeutic_target	gene	0.60
BAX	therapeutic_target	gene	0.60
Pi3K/Akt	therapeutic_target	pathway	0.60
Osteoblast	regulates	cell_type	0.60
Osteoclast	regulates	cell_type	0.60
Cathepsin	regulates	protein	0.60
Collagen	regulates	protein	0.60
Cytokine	regulates	protein	0.60
ubiquitin-proteasome	participates_in	pathway	0.60

Incoming (98)

Source	Relation	Type	Str
PRKCH	regulates	gene	0.90
Osteoking	upregulates	drug	0.90
H3K14la	associated_with	phenotype	0.85
PIEZO1	activates	protein	0.80
H3K9la	regulates	phenotype	0.80
BMP2	inhibits	gene	0.70
AMPK	inhibits	gene	0.70
ANGPT1	activates	gene	0.60
BMP2	activates	gene	0.60
PDGFRB	activates	gene	0.60
AND	interacts_with	gene	0.60
BMAL1	interacts_with	gene	0.60
MAPK	expressed_in	gene	0.60
JNK	inhibits	gene	0.60
ATM	associated_with	gene	0.60
AND	associated_with	gene	0.60
HDAC9	associated_with	gene	0.60
GLS1	activates	gene	0.60
YAP	activates	gene	0.60
BAX	activates	gene	0.60
VEGF	activates	gene	0.60
FGF2	activates	gene	0.60
RANK	regulates	gene	0.60
RANKL	regulates	gene	0.60
ATF4	associated_with	gene	0.60
ERK	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
AKT	associated_with	gene	0.60
HIPPO	regulates	gene	0.60
TAZ	associated_with	gene	0.60
MIRNAS	regulates	gene	0.60
DLAT	inhibits	gene	0.60
GENES	associated_with	gene	0.60
JNK	associated_with	gene	0.60
PI3K	activates	gene	0.60
VEGFB	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
BCL2	activates	gene	0.60
MTOR	activates	gene	0.60
RANKL	therapeutic_target	gene	0.60
DRP1	activates	gene	0.60
MFN1	activates	gene	0.60
OPA1	activates	gene	0.60
LARS2	activates	gene	0.60
MFN2	activates	gene	0.60
AND	activates	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60
BAX	therapeutic_target	gene	0.60
BCL2	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RUNX2 in their description or question text

No additional research found