P38 MAPK

Understanding Entity Pages

This page aggregates everything SciDEX knows about P38 MAPK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

p38 MAPK is a stress-activated kinase (p38 alpha/beta/gamma/delta) regulating neuroinflammation, tau phosphorylation, and neuronal apoptosis in Alzheimer's and Parkinson's disease

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flowchart TD
    N0["P38 Mapk"]
    N1["P38"]
    N1 -->|"activates"| N0
    N2["INFLAMMATION"]
    N2 -->|"activates"| N0
    N3["Inflammation"]
    N3 -->|"activates"| N0
    N4["Neurodegeneration"]
    N0 -->|"involved in"| N4
    N5["ERK"]
    N5 -->|"activates"| N0
    N6["IL-6"]
    N6 -->|"activates"| N0
    N7["Als"]
    N7 -->|"activates"| N0
    N8["CANCER"]
    N8 -->|"activates"| N0
    N9["Tumor"]
    N9 -->|"activates"| N0
    N10["Cancer"]
    N10 -->|"activates"| N0
    N11["APOPTOSIS"]
    N11 -->|"activates"| N0
    N12["NEUROTOXICITY"]
    N12 -->|"activates"| N0
    N13["JNK"]
    N13 -->|"activates"| N0
    N14["CYTOKINES"]
    N14 -->|"activates"| N0
    N15["JUN"]
    N15 -->|"activates"| N0

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    class N5 gene
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    class N8 gene
    class N9 disease
    class N10 disease
    class N11 gene
    class N12 gene
    class N13 gene
    class N14 gene
    class N15 gene