concept

UNFOLDED PROTEIN RESPONSE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UNFOLDED PROTEIN RESPONSE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1224Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

UNFOLDED PROTEIN RESPONSE is a concept in neurodegeneration research. Key relationships include: co discussed, causes, activates. Associated with FRONTOTEMPORAL. Connected to 14 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	UNFOLDED PROTEIN RESPONSE
Key Genes/Proteins	ACHE, ACTIN, AD, AMPK, AMYLOID, APC
Related Diseases	AGING, ALS, ALZHEIMER'S DISEASE
Related Pathways	APOPTOSIS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Unfolded Protein Response (UPR)

mechanism · 3651 words

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Pathway Diagram

graph TD
    UNFOLDED_PROTEIN_RESPONSE["UNFOLDED PROTEIN RESPONSE"]
    UNFOLDED_PROTEIN_RESPONSE -->|"regulates"| ER_homeostasis["ER homeostasis"]
    UNFOLDED_PROTEIN_RESPONSE -->|"interacts"| Mtor["Mtor"]
    UNFOLDED_PROTEIN_RESPONSE -->|"interacts"| Apoptosis["Apoptosis"]
    UNFOLDED_PROTEIN_RESPONSE -->|"interacts"| Autophagy["Autophagy"]
    UNFOLDED_PROTEIN_RESPONSE -->|"interacts"| Oxidative_Stress["Oxidative Stress"]
    SPHK1["SPHK1"] -->|"activates"| UNFOLDED_PROTEIN_RESPONSE
    TARDBP["TARDBP"] -->|"activates"| UNFOLDED_PROTEIN_RESPONSE
    PINK1["PINK1"] -->|"activates"| UNFOLDED_PROTEIN_RESPONSE
    LC3["LC3"] -->|"activates"| UNFOLDED_PROTEIN_RESPONSE
    MTOR["MTOR"] -->|"activates"| UNFOLDED_PROTEIN_RESPONSE
    PTEN["PTEN"] -->|"activates"| UNFOLDED_PROTEIN_RESPONSE
    VCP["VCP"] -->|"activates"| UNFOLDED_PROTEIN_RESPONSE
    TBK1["TBK1"] -->|"activates"| UNFOLDED_PROTEIN_RESPONSE

Outgoing (148)

Target	Relation	Type	Str
ER homeostasis	regulates	phenotype	0.90
oligodendrocytes	active_in	cell_type	0.90
Protein Folding	modulates	process	0.90
Protein Quality Control	activates	process	0.90
macrophages	active_in	cell_type	0.90
Neuronal Apoptosis	mediates	process	0.90
microglia	active_in	cell_type	0.90
neural stem cells	active_in	cell_type	0.90
BAX/BCL-2 ratio	upstream_of	phenotype	0.90
cortex	active_in	brain_region	0.90
Protein Folding	regulates	process	0.90
hippocampus	active_in	brain_region	0.90
neurons	active_in	cell_type	0.90
endothelial cells	active_in	cell_type	0.90
thalamus	active_in	brain_region	0.90
astrocytes	active_in	cell_type	0.90
blood-brain barrier	active_in	brain_region	0.90
Dipeptide Repeat Protein Aggregation	involved_in	process	0.85
BAX	upregulates	protein	0.85
Protein Degradation	associated_with	process	0.85
Apoptosis	associated_with	process	0.85
ER homeostasis	associated_with	phenotype	0.80
Neurodegeneration	contributes_to	process	0.80
hypothalamus	active_in	brain_region	0.80
spinal cord	active_in	brain_region	0.80
pyramidal neurons	active_in	cell_type	0.80
aging	associated_with	phenotype	0.78
Memory	associated_with	phenotype	0.75
Synaptic Function	associated_with	process	0.75
Cognition	associated_with	phenotype	0.75
NK cells	active_in	cell_type	0.70
substantia nigra	active_in	brain_region	0.70
pericytes	active_in	cell_type	0.70
prefrontal cortex	active_in	brain_region	0.70
dopaminergic neurons	active_in	cell_type	0.70
T cells	active_in	cell_type	0.70
B cells	active_in	cell_type	0.70
ASTROCYTES	phosphorylates	cell_type	0.65
ASTROCYTES	regulates	cell_type	0.65
ASTROCYTES	produces	cell_type	0.65
APP	produces	gene	0.65
ER STRESS	regulates	phenotype	0.65
NEURONS	causes	cell_type	0.65
NEURODEGENERATION	protects_against	disease	0.65
AGING	regulates	phenotype	0.65
MITOCHONDRIAL DYSFUNCTION	interacts_with	phenotype	0.65
cerebral cortex	active_in	brain_region	0.60
mast cells	active_in	cell_type	0.60
Schwann cells	active_in	cell_type	0.60
amygdala	active_in	brain_region	0.60

Incoming (1076)

Source	Relation	Type	Str
APOPTOSIS	activates	gene	1.00
AUTOPHAGY	activates	gene	1.00
GENES	activates	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
ER Stress	activates	process	0.95
Endoplasmic Reticulum Stress	associated_with	process	0.95
Endoplasmic Reticulum	activates	organelle	0.95
BDNF	participates_in	gene	0.90
glioblastoma	involves	disease	0.90
depression	involves	disease	0.90
TNF	participates_in	gene	0.90
ROS	participates_in	gene	0.90
Alzheimer's disease	involves	disease	0.90
PI3K	participates_in	gene	0.90
neurodegeneration	involves	disease	0.90
SLC7A11	participates_in	gene	0.90
APOE	participates_in	gene	0.90
NLRP3	participates_in	gene	0.90
PI3K-AKT-mTOR signaling	crosstalk_with	pathway	0.90
GPX4	participates_in	gene	0.90
Parkinson's disease	involves	disease	0.90
frontotemporal dementia	involves	disease	0.90
ER stress	activates	process	0.90
STING	participates_in	gene	0.90
aging	involves	disease	0.90
NF-kB signaling	crosstalk_with	pathway	0.90
TGF-beta signaling	crosstalk_with	pathway	0.90
IFN	participates_in	gene	0.90
MTOR	participates_in	gene	0.90
ferroptosis	crosstalk_with	pathway	0.90
ALS	participates_in	gene	0.90
neuroinflammation	involves	disease	0.90
ALS	involves	disease	0.90
RNA	participates_in	gene	0.90
cGAS-STING	crosstalk_with	pathway	0.90
lipid metabolism	crosstalk_with	pathway	0.90
pyroptosis	crosstalk_with	pathway	0.90
GSK2606414	inhibits	drug	0.90
MAPK	participates_in	gene	0.90
spinal muscular atrophy	involves	disease	0.90
Cancer	therapeutic_target	disease	0.90
Als	therapeutic_target	disease	0.90
Als	activates	disease	0.90
Tdp-43 Fibrils	activates	protein	0.87
microglia	active_in	cell_type	0.85
DAM microglia	active_in	cell_type	0.85
IL-10	participates_in	gene	0.85
TGF	participates_in	gene	0.85
neurons	active_in	cell_type	0.85
astrocytes	active_in	cell_type	0.85

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity