concept

ACHE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACHE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1069Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

ACHE is a concept in neurodegeneration research. Key relationships include: activates, inhibits, associated with. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 279 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ACHE
Key Genes/Proteins	AB, ABCA1, ACETYL-COA, ACHE, AD, ADAM10
Related Diseases	acetylcholine, Aging, Als
Related Pathways	Akt

Pathway Diagram

graph TD
    ACHE["ACHE"]
    ACHE -->|"activates"| Alzheimer["Alzheimer"]
    ACHE -->|"activates"| Neurodegeneration["Neurodegeneration"]
    ACHE -->|"activates"| Als["Als"]
    ACHE -->|"activates"| Inflammation["Inflammation"]
    ACHE -->|"activates"| Ms["Ms"]
    ACHE -->|"activates"| Anxiety["Anxiety"]
    ACHE -->|"target for"| Cardiac["Cardiac"]
    BPMC["BPMC"] -->|"inhibits"| ACHE
    MBP["MBP"] -->|"activates"| ACHE
    GENES["GENES"] -->|"activates"| ACHE
    MANF["MANF"] -->|"activates"| ACHE
    FLAVONOIDS["FLAVONOIDS"] -.biomarker for.-> ACHE
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| ACHE
    PI3K["PI3K"] -->|"activates"| ACHE
    AKT["AKT"] -->|"activates"| ACHE
    TNF["TNF"] -.biomarker for.-> ACHE
    CAT["CAT"] -.biomarker for.-> ACHE

Outgoing (891)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ACHE	data_in	dataset_row	0.00
ACHE	encodes	protein	0.00
ds-6784494f1741	provides_data_for	dataset	1.00
ds-6784494f1741	data_in	dataset	1.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Als	inhibits	disease	0.85
denervation	promotes	phenotype	0.85
Acetylcholine	degrades	compound	0.82
Apoptosis	activates	pathway	0.80
Als	activates	disease	0.75
Neurodegeneration	activates	disease	0.75
TNF	expresses	gene	0.70
APP	causes	gene	0.70
DRD2	inhibits	gene	0.70
GRIA1	regulates	gene	0.70
NEURONS	associated_with	cell_type	0.70
APP	biomarker_for	gene	0.70
C9ORF72	expresses	gene	0.70
MICROGLIA	activates	cell_type	0.70
TREM2	targets	gene	0.70
APOE	biomarker_for	gene	0.70
MOTOR NEURON	associated_with	cell_type	0.70
CDK5	inhibits	gene	0.70
APOE	mediates	gene	0.70
ATG5	activates	gene	0.70
NFKB	activates	gene	0.70
ATG7	activates	gene	0.70
LRRK2	targets	gene	0.70
VEGF	activates	gene	0.70
MICROGLIA	targets	cell_type	0.70
GBA	interacts_with	gene	0.70
NEURONS	interacts_with	cell_type	0.70
NLRP3	targets	gene	0.70
NEURONS	mediates	cell_type	0.70
IGF1	activates	gene	0.70
NRF2	expresses	gene	0.70
ENDOTHELIAL	activates	cell_type	0.70
HIF1A	activates	gene	0.70
PARP1	activates	gene	0.70
GBA	inhibits	gene	0.70
BACE1	inhibits	gene	0.70
JAK	markers	gene	0.70
JAK	inhibits	gene	0.70
WNT	regulates	gene	0.70
WNT	activates	gene	0.70
TAU	protects_against	gene	0.70
UNFOLDED PROTEIN RESPONSE	activates	pathway	0.70
WNT	protects_against	gene	0.70
APOE	protects_against	gene	0.70
MICROGLIA	interacts_with	cell_type	0.70

Incoming (178)

Source	Relation	Type	Str
H6	donepezil_target	hypothesis	0.00
benchmark_ot_ad_answer_key:ACHE	data_in	dataset_row	0.00
ACHE	encodes	gene	0.00
ds-6784494f1741	data_in	dataset	1.00
ds-83b31ef18d49	data_in	dataset	1.00
Bpmc	inhibits	compound	0.90
Bpmc	downregulates	compound	0.90
Chlorogenic acid	downregulates	compound	0.85
Fisetin	downregulates	compound	0.85
NORAD	regulates	gene	0.80
APOPTOSIS	activates	gene	0.80
BPMC	inhibits	drug	0.72
OXIDATIVE STRESS	activates	gene	0.70
NEUROTOXICITY	activates	gene	0.70
GFAP	activates	gene	0.70
APP	causes	gene	0.65
INFLAMMATION	inhibits	gene	0.60
HRAS	therapeutic_target	gene	0.60
CIRCADIAN RHYTHM	therapeutic_target	gene	0.60
SYN2A	activates	gene	0.60
CATALASE	inhibits	gene	0.60
TAU	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
DIABETES MELLITUS	inhibits	gene	0.60
AMYLOID	inhibits	gene	0.60
SYP	activates	gene	0.60
NGF	activates	gene	0.60
AMPK	activates	gene	0.60
PRESENILIN	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
ROS	activates	gene	0.60
AXON	activates	gene	0.60
TUBULIN	activates	gene	0.60
NEURON	activates	gene	0.60
ALZHEIMER	causes	gene	0.60
AMYLOID	causes	gene	0.60
ACETYL-COA	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AMYLOID	associated_with	gene	0.60
GADD45A	causes	gene	0.60
P62	causes	gene	0.60
ROS	inhibits	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
IL-6	inhibits	gene	0.60
MBP	inhibits	gene	0.60
KEAP1	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
BDNF	activates	gene	0.60
BACE1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What is the optimal dosage and timing of melatonin administration for AD prevent

neurodegeneration | 2026-04-26 | 7 hypotheses Top: 0.735

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What is the optimal dosage and timing of melatonin administration for AD prevent

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

Related Research

Hypotheses and analyses mentioning ACHE in their description or question text

No additional research found