concept

MELATONIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MELATONIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

234Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

9Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	MELATONIN
Key Genes/Proteins	ACSL4, AMYLOID, AMYLOID-BETA, APP, AQP4
Related Diseases	ACETYLCHOLINE, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, APOPTOSIS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

therapeutic · 4539 words

→

Pathway Diagram

graph TD
    MELATONIN["MELATONIN"]
    style MELATONIN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    MELATONIN -->|"treats"| Sepsis_Induced_Acute_Kidney_In["Sepsis-Induced Acute Kidney Injury"]
    MELATONIN -->|"upregulates"| SOX2([SOX2])
    MELATONIN -->|"upregulates"| OCT4([OCT4])
    MELATONIN -->|"upregulates"| NANOG([NANOG])
    MELATONIN -->|"upregulates"| POU5F1([POU5F1])
    MELATONIN -.->|"protects against"| mitochondrial_dysfunction(mitochondrial dysfunction)
    MELATONIN -->|"treats"| Alzheimer_s_Disease["Alzheimer's Disease"]
    MELATONIN -->|"activates"| Mitophagy["Mitophagy"]
    MELATONIN -.->|"biomarker for"| CIRCADIAN_RHYTHM["CIRCADIAN RHYTHM"]
    MELATONIN -->|"modulates"| Skin_Fibroblasts["/Skin Fibroblasts/"]
    Circadian_Clock_Genes["Circadian Clock Genes"] -->|"regulates"| MELATONIN
    Circadian["Circadian"] -->|"interacts"| MELATONIN
    RPL18A([RPL18A]) -->|"regulates"| MELATONIN

Outgoing (175)

Target	Relation	Type	Str
SIRT1	upregulates	gene	0.95
Polycystic Ovary Syndrome	treats	disease	0.90
mitochondrial dysfunction	protects_against	phenotype	0.90
Alzheimer's Disease	treats	disease	0.90
Alzheimer'S Disease	treats	disease	0.90
CIRCADIAN RHYTHM	biomarker_for	entity	0.90
oxidative stress	inhibits	process	0.85
OBSTRUCTIVE SLEEP APNEA SYNDROME	biomarker_for	entity	0.85
Oxidative Stress	modulates	process	0.85
SIRT1	activates	gene	0.85
Neuroinflammation	modulates	process	0.85
Neuroinflammation	inhibits	process	0.85
Oxidative Stress	inhibits	process	0.85
APOPTOSIS	suppresses	process	0.85
Mitochondrial Membrane Potential	protects_against	biomarker	0.84
mtDNA damage	protects_against	phenotype	0.82
Autism Spectrum Disorder	treats	disease	0.80
postoperative sleep disorder	treats	disease	0.80
mitophagy	regulates	pathway	0.80
Alzheimer'S Disease	protects_against	disease	0.80
Amyloidosis	modulates	process	0.80
NRF2	activates	protein	0.80
Nrf2	activates	pathway	0.80
CREB/RCAN1	activates	pathway	0.80
Circadian Rhythmicity	marker_of	biological_process	0.80
MMP2	targets	gene	0.80
NR3C1	targets	gene	0.80
NF-κB	inhibits	pathway	0.75
Circadian	interacts_with	entity	0.70
Alzheimer's disease	treats	disease	0.70
FERROPTOSIS	protects_against	phenotype	0.70
Circadian	inhibits	entity	0.70
Circadian	regulates	entity	0.70
Alzheimer's disease	protects_against	disease	0.70
AMYLOID	inhibits	protein	0.70
NEURODEGENERATION	interacts_with	phenotype	0.70
TLR4	treats	gene	0.70
MITOPHAGY	inhibits	phenotype	0.70
APP	activates	gene	0.70
TLR4	activates	gene	0.70
atherosclerosis	treats	disease	0.70
Circadian	activates	entity	0.70
TAU	phosphorylates	protein	0.70
reactive oxygen species	inhibits	process	0.70
MITOPHAGY	treats	phenotype	0.70
AMYLOID	treats	protein	0.70
PS-NP-induced neurodegeneration	protects_against	disease	0.70
MT1 receptor	activates	protein	0.70
LRP1	activates	gene	0.70
cGAS-STING1-TBK1	activates	pathway	0.70

Incoming (59)

Source	Relation	Type	Str
ORAS	modulates	disease	0.80
NR3C1	involved_in	gene	0.70
MMP2	involved_in	gene	0.70
NEURODEGENERATION	stabilizes	phenotype	0.70
AMYLOID	stabilizes	protein	0.70
SEROTONIN	causes	phenotype	0.70
RPL18A	regulates	gene	0.70
APP	treats	gene	0.70
TAU	treats	protein	0.70
Circadian	interacts_with	entity	0.70
PINK1	treats	gene	0.65
STING	inhibits	gene	0.65
APP	stabilizes	gene	0.60
NEURON	targets	cell_type	0.60
BIPOLAR DISORDER	associated_with	disease	0.50
ASTROCYTES	associated_with	cell_type	0.50
SCHIZOPHRENIA	associated_with	disease	0.50
PHAGOCYTOSIS	associated_with	phenotype	0.50
ENDOTHELIAL CELLS	associated_with	cell_type	0.50
SYNAPTIC LOSS	associated_with	phenotype	0.50
HIPPOCAMPUS	associated_with	brain_region	0.50
AMYLOID-BETA	associated_with	protein	0.50
PRAMIPEXOLE	associated_with	drug	0.45
MEMANTINE	associated_with	drug	0.45
ACSL4	associated_with	gene	0.45
FIBROSIS	associated_with	disease	0.45
KYNURENINE PATHWAY	associated_with	pathway	0.45
KYNURENINE	associated_with	phenotype	0.45
FERROPTOSIS	associated_with	phenotype	0.45
INFLAMMATION	associated_with	phenotype	0.45
NEUROINFLAMMATION	associated_with	phenotype	0.45
PYROPTOSIS	associated_with	phenotype	0.45
CGAS-STING PATHWAY	associated_with	pathway	0.45
DENTATE GYRUS	associated_with	brain_region	0.45
FRONTOTEMPORAL DEMENTIA	associated_with	disease	0.45
SUBSTANTIA NIGRA	associated_with	brain_region	0.45
STEM CELLS	associated_with	cell_type	0.45
SORAFENIB	associated_with	drug	0.45
OXIDATIVE STRESS	associated_with	phenotype	0.45
SYNAPTIC PLASTICITY	associated_with	phenotype	0.45
FIBROBLASTS	associated_with	cell_type	0.45
NEUROBLASTOMA	associated_with	disease	0.45
SENESCENCE	associated_with	phenotype	0.45
CARDIOMYOCYTES	associated_with	cell_type	0.45
NRF2 PATHWAY	associated_with	pathway	0.45
NICOTINAMIDE	associated_with	drug	0.45
DOPAMINE	associated_with	phenotype	0.45
GABA	associated_with	phenotype	0.45
AUTOPHAGY	associated_with	phenotype	0.45
CREB	associated_with	gene	0.45

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Circadian Glymphatic Rescue Therapy (Melatonin-focused)	0.712	neurodegeneration	Sleep disruption as cause and consequenc

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (9)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs AD with Co	clinical	Alzheimer's Disease	0.900	0.50	aortic endothelial cells	proposed	$6,550,000
Circadian-Vascular-Metabolic Syndrome (CVMS) Intervention Trial	clinical	Neurodegeneration	0.400	0.50	human	proposed	$3,900,000
DLB Cognitive Fluctuation Mechanism Experiment	clinical	Neurodegeneration	0.400	0.50	human	proposed	$6,550,000
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Non-Motor Symptom Progression in Parkinson's Disease — Mechanisms and	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
NPH Glymphatic System Interaction Experiment	clinical	Neurodegeneration	0.400	0.50	human	proposed	$5,460,000
Sleep and Circadian Dysfunction as Driver of Neurodegeneration	clinical	Neurodegeneration	0.400	0.50	human	proposed	$5,460,000
Sleep Disruption and Alzheimer's Disease — mechanism and intervention	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Sleep and Respiratory Network Interaction in ALS — Experiment Design	clinical	ALS	0.400	0.50	human	proposed	$5,460,000

Related Papers (19)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Prevalence of symptoms of depression, anxiety, insomnia, posttraumatic stress di [PMID:33285346]	Cénat JM, Blais-Rochette C, Kokou-Kpolou	Psychiatry Res	2021	1
Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Seque [PMID:32822576]	Maynard A, McCoach CE, Rotow JK, Harris	Cell	2020	1
The Ca(2+) Sensor SCaBP3/CBL7 Modulates Plasma Membrane H(+)-ATPase Activity and [PMID:30962395]	Yang Y, Wu Y, Ma L, Yang Z, Dong Q, Li Q	Plant Cell	2019	1
Sleep drives metabolite clearance from the adult brain. [PMID:24136970]	Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th	Science	2013	1
Impact of preinterventional plaque composition and eccentricity on late-acquired [PMID:22936019]	Sato T, Kameyama T, Noto T, Nozawa T, In	Coron Artery Dis	2012	1
Melatonin Promotes the Synthesis and Secretion of Growth Hormone in the Adenohyp [PMID:41870323]	["Zheng Y", "Chen Q", "Guo H", "Zhang Y"	Journal of pineal research	2026	0
Screening natural raw materials and product development for improving insomnia b [PMID:41578474]	["Yue L", "Jiao Q", "Li J", "Lu Y", "Yi	Medicine	2026	0
Pharmacological modulation of MRAP2 protein on murine melatonin receptor signali [PMID:40510472]	Song W, Li Y, Xu H, Zhang Y, Liu L, Li Y	Frontiers in endocrinology	2025	0
Regulation of therapeutic protein release in response to circadian biomarkers. [PMID:41198646]	Franko N, Li S, Galvan S, Csorba Z, Teix	Nature communications	2025	0
Polymorphisms in MTNR1A (rs2119882) and CLOCK (rs1801260) genes are associated w [PMID:40705802]	Chi Y, Yang X, Deng D, Li P, Zhang Y	PloS one	2025	0
Electroconvulsive Therapy Versus Repetitive Transcranial Magnetic Stimulation in [PMID:38456234]	Katarzyna Popiolek; Tor Arnison; Robert	The journal of ECT	2024	0
Finger friction with leather and seam of new and used softballs with and without [PMID:35678234]	["Kinoshita H"]	Sports biomechanics	2024	0
System-Level Strategies to Improve Home Dialysis: Policy Levers and Quality Init [PMID:37678234]	["Watnick S", "Blake P", "Mehrotra R", "	Clinical journal of the Americ	2023	0
Recommendations for risk minimization when using Janus kinase inhibitors for the [PMID:37345890]	["Wohlrab J", "Kegel T", "Gro\u00dfe R",	Journal der Deutschen Dermatol	2023	0
In Vitro Anticancer Activity of the Light Stable Zinc Isotope (64Zn) Compounds. [PMID:36456123]	["Novak P", "Balakin A", "Temnik M"]	Anticancer research	2022	0
Fascia iliaca compartment block. [PMID:33456890]	N O'Reilly; M Desmet; R Kearns	BJA education	2021	0
A long-term follow-up study on otoacoustic emissions testing in paediatric patie [PMID:31234890]	["Reiterer E", "Reider S", "Lackner P",	Malaria journal	2019	0
Severe refractory idiopathic warm autoimmune haemolytic anaemia responsive to co [PMID:30567234]	["Neave L", "Wilson A", "Lissack M", "Sc	BMJ case reports	2018	0
Metformin and lung cancer risk in patients with type 2 diabetes mellitus. [PMID:28456789]	["Tseng C"]	Oncotarget	2017	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MELATONIN in their description or question text

No additional research found