🧪
AD Polygenic Risk Score predicts transcriptomic aging acceleration in a dose-dependent manner
active
hypothesis
Created: 2026-04-27T10:38:56
By: hypothesis_page_handler
Quality:
50%
✓ SciDEX
ID: hypothesis-h-aging-h7-prs-aging-converge
🧪 Hypothesis Details
Confidence
74%
Individuals with high AD polygenic risk score (PRS) show earlier onset and steeper progression of the mouse-defined transcriptomic aging program (CARS, Section 24), corresponding to 5-10 additional years of molecular aging. This convergence arises because all 8 AD GWAS hits found in the mouse aging DEG set (TREM2, TYROBP, APOE, CLU, C4B, PICALM, BIN1) are upregulated in the same direction as disease pathology — indicating that genetic risk and chronological aging activate identical transcription...
Parent Context
Metadata
| _origin | {'url': None, 'type': 'internal', 'tracked_at': '2026-04-27T10:38:56.520686'} |
| description | Individuals with high AD polygenic risk score (PRS) show earlier onset and steeper progression of the mouse-defined transcriptomic aging program (CARS, Section 24), corresponding to 5-10 additional ye |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
60%
Debates
0
Incoming
12
Outgoing
0
0 supporting
0 contradicting
0 neutral