protein 1,246 words KG: TYROBP
Contents

TYROBP Protein (DAP12)

🔬 Protein Info
Gene SymbolTYROBP
AliasesDAP12
Chromosome19q13.12
Protein TypeAdaptor Protein
Functionis a transmembrane signaling adaptor protein that plays critical roles in innate immunity and microglial function in the central nervous system.
Primary ExpressionMicroglia, Monocytes, NK cells, Osteoclasts
Molecular Weight12.1 kDa
Amino Acids113 aa
PathwaysInnate Immunity
UniProt IDQ9Y241
NCBI Gene ID7305
Ensembl IDENSG00000111653
OMIM605712
GeneCardsTYROBP
Human Protein AtlasTYROBP
Associated DiseasesAging, Als, Alzheimer, alzheimer_disease, Alzheimer's disease
Known Drugs/CompoundsBERBERINE
InteractionsAKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-BETA, AND
SciDEX HypothesesTYROBP (DAP12) Conditional Antagonism for Early-St
KG Connections383 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (18)

TYROBP (DAP12) Conditional Antagonism for Early-Stage Neurop
Score: 0.84
TREM2 Deficiency Drives Microglial Senescence via Lipid Meta
Score: 0.82
TREM2 Crosstalk and Synergistic Activation of Phagocytic Tra
Score: 0.74
TREM2 Agonism to Restore Microglial Phagocytosis Across Both
Score: 0.73
TREM2-DAP12 Signalosome Enhancement — Boosting PI3K-AKT-mTOR
Score: 0.72
TREM2 haploinsufficiency dysregulates microglial synaptic su
Score: 0.70
Microglia and complement sustain post-Aβ neurodegeneration a
Score: 0.69
Microglial TREM2 state determines whether C1q-tagged substra
Score: 0.67
Anti-inflammatory microglial reprogramming via cystatin-C/TR
Score: 0.64
TREM2-Dependent Senescent Microglia Disrupt Astrocyte Commun
Score: 0.60
TREM2 Signaling Bifurcation with Independent TYROBP-Independ
Score: 0.59
Disease-Associated Microglia (DAM) Program Drives IBA1 Downr
Score: 0.57
SYK-Independent TREM2 Pathways Remain Functional in TYROBP D
Score: 0.55
Temporal TREM2 Pathway Modulation
Score: 0.48
TYROBP-SYK Pathway Enhancement
Score: 0.48
TYROBP Network Hyperactivation Marks Point of No Return
Score: 0.46
Rare TREM2-TYROBP pathway variants complement standard PRS b
Score: 0.38
TYROBP Causal Network Inhibition for Microglial Repolarizati
Score: 0.10

Knowledge Graph (12 edges)

TYROBP interacts_with TREM2
TYROBP interacts_with SIRP1β
TYROBP interacts_with CD33
TYROBP interacts_with CR3
TYROBP associated_with alzheimer_disease
TYROBP activates RANK
TYROBP associated_with APP
TYROBP associated_with TREM2
TYROBP associated_with PSEN1
TYROBP associated_with CD33

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