Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about classical_complement_cascade: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| HDAC3 | involved_in | gene | 0.40 |
| C4B | involved_in | gene | 0.40 |
| C1QA, PVALB | involved_in | gene | 0.40 |
| C1QA, C1QB | involved_in | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TNF-α–C1r/C1s Bridge Between NF-κB and Classical Complement | 0.600 | neuroinflammation | How does sevoflurane-induced NF-κB activ |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.747
neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.659
neurodegeneration | 2026-04-04 | 9 hypotheses Top: 0.914
neurodegeneration | 2026-04-03 | 42 hypotheses Top: 0.910
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.76 · 2026-04-16
closed · Rounds: 4 · Score: 0.81 · 2026-04-14
closed · Rounds: 4 · Score: 0.95 · 2026-04-10
closed · Rounds: 4 · Score: 0.95 · 2026-04-03
Hypotheses and analyses mentioning classical_complement_cascade in their description or question text
No additional research found