Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CXCL10 inhibition: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| white matter preservation | causes (CXCL10 antagonists would preserve white matter int) | mechanism | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| White Matter Oligodendrocyte Protection via CXCL10 Inhibitio | 0.675 | neurodegeneration | Gene expression changes in aging mouse b |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 43 hypotheses Top: 0.893
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| CXCL10 biomarker analysis for CPSP prediction | clinical | chronic postsurgical pain | 0.900 | 0.00 | human patients undergoing thor | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| METTL3/CXCL10 axis contributes to renal fibrosis by promoting the apoptosis of t [PMID:41138934] | Sun Y, Ren Z, Ge J, Zhang W, Shao F et a | Biochim Biophys Acta Mol Basis | 2026 | 0 |
| IL-25-ILC2-IL-13 axis improves traumatic brain injury by mediating CXCL-10-depen [PMID:41527095] | Peng M, Shu D, Chen Z, Yang Z, Zhang M e | J Neuroinflammation | 2026 | 0 |
| Oligodendrocyte transcription factor 2 orchestrates glioblastoma immune evasion [PMID:41591814] | Zhang X, Xue J, Zhao C, Zeng C, Zhong J | J Clin Invest | 2026 | 0 |
| Indole-3-propionic acid inhibits astrocyte inflammation and promotes motor funct [PMID:41663028] | Yu D, Kang J, Jiang W, Zhang C, Zhao X e | Neuropharmacology | 2026 | 0 |
| Cobrotoxin mitigates neuroinflammation and cognitive impairment by suppressing C [PMID:41671614] | Li Z, Tan B, Dong K, Yu X, Zhang SW et a | Biochem Pharmacol | 2026 | 0 |
| Peripheral macrophages and T-cells accumulate in the degenerating optic tract af [PMID:41740873] | Main BS, Villapol S, Buenaventura RG, Ha | Brain Behav Immun | 2026 | 0 |
| Melanoma cell inoculation improves cognitive impairment in the 5xFAD mouse model [PMID:41760781] | Bruna-Jara B, More J, Lobos P, Ponce DP, | Scientific reports | 2026 | 0 |
| Chemokine-defined macrophage niches establish spatial organization of tumor immu [PMID:41872505] | Ghosh S, Li X, Rawat K, Dighal A, Kalino | Nat Immunol | 2026 | 0 |
| Agonists for cytosolic bacterial receptor ALPK1 induce antitumour immunity. [PMID:41372408] | Tian X, Liu J, Li Y, Wang Y, Luo Y, He H | Nature | 2026 | 0 |
| HTLV1-associated myelopathy as a translational model of progressive neurodegener [PMID:41926707] | da Silva MTT, Araujo AQC | Brain : a journal of neurology | 2026 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning CXCL10 inhibition in their description or question text
No additional research found