gene 619 words KG: CXCL10
Contents

CXCL10 - C-X-C Motif Chemokine Ligand 10

🧬 Gene Info
Gene SymbolCXCL10
Full NameC-X-C Motif Chemokine Ligand 10
Chromosome4q21
FunctionCXCL10 has essential functions in immune surveillance and inflammation:
Molecular Weight~10 kDa
PathwaysAkt, Immune Response, Inflammasome, Mapk, Pi3K
NCBI Gene ID3627
GeneCardsCXCL10
Human Protein AtlasCXCL10
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease
Known Drugs/CompoundsLIRAGLUTIDE
InteractionsACHE, AD, AGING, AKT, AND, APOPTOSIS
SciDEX HypothesesWhite Matter Oligodendrocyte Protection via CXCL10
White Matter Vulnerability Prevention via Oligoden
White Matter Immune Checkpoint Restoration
KG Connections968 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (32)

Purinergic Signaling Polarization Control
Score: 0.71
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.90
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Senescent Cell Mitochondrial DNA Release
Score: 0.74
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
Aquaporin-4 Polarization Rescue
Score: 0.73
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Microglial Purinergic Reprogramming
Score: 0.70
Complement C1q Mimetic Decoy Therapy
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68
Complement C1q Subtype Switching
Score: 0.66
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
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Related Analyses (11)

Systemic immune profiling and peripheral immune contribution
neurodegeneration · completed
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · completed
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

QTJD effects on macrophage polarization and inflammatory res
exploratory · proposed · Score: 0.95
CXCL10 biomarker analysis for CPSP prediction
clinical · proposed · Score: 0.90

See Also (15)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
A1 Reactive Astrocytes
cell · KG edge: associated_with
ANG — Angiogenin
gene · KG edge: associated_with
Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: biomarker_for
Alzheimer Indonesia
institution · KG edge: associated_with

Knowledge Graph (12 edges)

CXCL10 participates_in INTERFERON_RESPONSE
CXCL10 interacts_with CXCR3
IFN_GAMMA activates CXCL10
A1_ASTROCYTES expressed_in CXCL10
CXCL10 activates TNF
CSF2 regulates CXCL10
NAMPT regulates CXCL10
FGF2 regulates CXCL10
CXCL10 regulates HSPA1A
CXCL10 regulates FGF8

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