gene

GAL3ST1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GAL3ST1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

1Hypotheses

1Analyses

4Outgoing

6Incoming

0Experiments

1Debates

Summary

GAL3ST1 (Galactose-3-O-Sulfotransferase 1) encodes cerebroside sulfotransferase, essential for sulfatide biosynthesis in myelin. Deficiency causes metachromatic leukodystrophy (MLD). Also involved in immune function, kidney biology, and cancer metastasis.

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🧬 Gene Info

Gene Symbol	GAL3ST1
Full Name	Galactose-3-O-Sulfotransferase 1
Aliases	Cerebroside Sulfotransferase
Chromosome	22q13.33
Function	catalyzes sulfatide biosynthesis
Primary Expression	immune cells and modulates immune responses:
Subcellular Localization	the Golgi apparatus
Molecular Weight	46 kDa
Amino Acids	423 aa
Exons	8
UniProt ID	Q04589
NCBI Gene ID	9512
Ensembl ID	ENSG00000149654
OMIM	604582
GeneCards	GAL3ST1
Human Protein Atlas	GAL3ST1
Associated Diseases	neurodegeneration
SciDEX Hypotheses	Myelin Sulfatide Restoration
KG Connections	10 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GAL3ST1 — AlphaFold Q04589 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

GAL3ST1 Gene

gene · 1204 words

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GAL3ST1 Protein

protein · 1609 words

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Pathway Diagram

graph TD
    GAL3ST1["GAL3ST1"]
    neurodegeneration["neurodegeneration"]
    GAL3ST1 -->|"implicated in"| neurodegeneration
    Als{"Als"}
    GAL3ST1 -->|"implicated in"| Als
    Cancer{"Cancer"}
    GAL3ST1 -->|"implicated in"| Cancer
    Immune_Function(["Immune Function"])
    GAL3ST1 -->|"regulates"| Immune_Function
    ROS["ROS"]
    GAL3ST1 ---|"interacts"| ROS
    style GAL3ST1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style Als fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Cancer fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Immune_Function fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f

Outgoing (4)

Target	Relation	Type	Str
neurodegeneration	associated_with	disease	0.50
sulfatide_synthesis	catalyzes	pathway	0.50
TREM2	co_associated_with	gene	0.40
STING1	co_associated_with	gene	0.40

Incoming (6)

Source	Relation	Type	Str
genes-gal3st1	documents	wiki_page	1.00
h-d16c2411	targets	hypothesis	0.90
h-d9604ebf	targets	hypothesis	0.90
CD300F	co_associated_with	gene	0.40
CDKN2A	co_associated_with	gene	0.40
CXCL10	co_associated_with	gene	0.40

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Myelin Sulfatide Restoration	0.623	neurodegeneration	Gene expression changes in aging mouse b

Mentioning Analyses (1)

Scientific analyses that reference this entity

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

neurodegeneration | 2026-04-03 | 44 hypotheses Top: 0.990

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What gene expression changes in the aging mouse brain predict neurodegenerative

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Related Research

Hypotheses and analyses mentioning GAL3ST1 in their description or question text

No additional research found