concept

NLGN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NLGN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

217Connections

2Hypotheses

2Analyses

50Outgoing

50Incoming

5Experiments

3Debates

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💡 Concept Info

Name	NLGN1
Key Genes/Proteins	ACSL4, Actin, ADNP, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID
Related Diseases	Aging, Als, ALS, Alzheimer, Alzheimer's disease
Related Pathways	Amyloid

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NLGN1["NLGN1"]
    style NLGN1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    NLGN1 -->|"binds"| heparan_sulfate["heparan sulfate"]
    NLGN1 -->|"interacts"| PSD95([PSD95])
    NLGN1 -->|"participates in"| synapse["synapse"]
    NLGN1 -->|"interacts"| neurexin([neurexin])
    NLGN1 -->|"regulates"| GluA1([GluA1])
    NLGN1 -->|"regulates"| Trans_Synaptic_Adhesion_Molecu["Trans-Synaptic Adhesion Molecule Modulation"]
    NLGN1 -.->|"inhibits"| Alzheimer["Alzheimer"]
    NLGN1 -.->|"inhibits"| Dementia["Dementia"]
    NLGN1 -.->|"inhibits"| Als["Als"]
    h_fdaae8d9["h-fdaae8d9"] -->|"targets"| NLGN1
    Hevin([Hevin]) -->|"regulates"| NLGN1
    FN([FN]) -->|"regulates"| NLGN1
    NRXN2A([NRXN2A]) -->|"interacts"| NLGN1
    amyloid_beta_oligomers([amyloid-beta oligomers]) -->|"modulates"| NLGN1
    NRXN3([NRXN3]) -->|"interacts"| NLGN1
    EXOSOMES([EXOSOMES]) -.->|"inhibits"| NLGN1
    ALZHEIMER([ALZHEIMER]) -.->|"inhibits"| NLGN1
    NRXN2([NRXN2]) -->|"interacts"| NLGN1
    DEMENTIA([DEMENTIA]) -.->|"inhibits"| NLGN1

Outgoing (140)

Target	Relation	Type	Str
heparan sulfate	binds	chemical	0.90
neurons	expressed_in	cell_type	0.80
PSD95	interacts_with	protein	0.80
neurexin	interacts_with	protein	0.80
GluA1	regulates	protein	0.80
neurons	activates	cell_type	0.70
hippocampus	expressed_in	brain_region	0.70
Trans-Synaptic Adhesion Molecule Modulation	regulates	mechanism	0.70
Multiple Sclerosis	expressed_in	disease	0.65
ALS	regulates	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Neurodegeneration	causes	disease	0.65
ALS	inhibits	disease	0.65
Aging	expressed_in	disease	0.65
Alzheimer	regulates	disease	0.65
Autism	encodes	disease	0.65
Als	regulates	disease	0.65
Als	inhibits	disease	0.65
Autism	regulates	disease	0.65
Alzheimer	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Autism	activates	disease	0.65
Dementia	inhibits	disease	0.65
Neurodegeneration	regulates	disease	0.65
Aβ	inhibits	protein	0.60
Amyloid-Beta	inhibits	protein	0.60
MTORC1	encodes	gene	0.60
Mtor	encodes	pathway	0.60
SYNAPSE	associated_with	gene	0.60
Aβ	therapeutic_target	protein	0.60
ALZHEIMER	regulates	gene	0.60
SYNAPSE	regulates	gene	0.60
cortex	expressed_in	brain_region	0.60
Alzheimer's disease	biomarker_for	disease	0.60
synaptic plasticity	participates_in	pathway	0.60
unfolded protein response	participates_in	pathway	0.60
neurons	protects_against	cell_type	0.60
neurons	associated_with	cell_type	0.60
neurons	interacts_with	cell_type	0.60
Alzheimer's disease	associated_with	disease	0.60
autism spectrum disorder	associated_with	disease	0.60
synaptic plasticity	involved_in	pathway	0.60
Neuron	activates	cell_type	0.60
Neuron	interacts_with	cell_type	0.60
SYNAPSE	activates	gene	0.60
Synaptic Plasticity	activates	pathway	0.60
AMYLOID-BETA	inhibits	gene	0.60
Neuron	inhibits	cell_type	0.60
MTORC1	activates	gene	0.60
Mtor	activates	pathway	0.60

Incoming (77)

Source	Relation	Type	Str
h-fdaae8d9	targets	hypothesis	0.90
Hevin	regulates	protein	0.80
FN	regulates	gene	0.70
AMYLOID-BETA	inhibits	gene	0.60
NRXN3	regulates	gene	0.60
NRXN2	regulates	gene	0.60
PSP	inhibits	gene	0.60
NGN1	regulates	gene	0.60
NGN2	regulates	gene	0.60
MEF2C	regulates	gene	0.60
EPHA5	regulates	gene	0.60
ADNP	expressed_in	gene	0.60
NRXN2A	interacts_with	protein	0.60
amyloid-beta oligomers	modulates	protein	0.60
NRXN3	interacts_with	protein	0.60
NRXN2	interacts_with	gene	0.60
NPTX2	interacts_with	gene	0.60
NRXN1	activates	gene	0.60
RORB	activates	gene	0.60
KCNIP4	activates	gene	0.60
APP	activates	gene	0.60
NCAM2	activates	gene	0.60
RORA	activates	gene	0.60
FGF14	activates	gene	0.60
GRIN2A	activates	gene	0.60
NRXN1	regulates	gene	0.60
DCC	associated_with	gene	0.60
NLGN2	inhibits	gene	0.60
GEPHYRIN	interacts_with	gene	0.60
NRXN1	interacts_with	gene	0.60
NLGN3	associated_with	gene	0.60
TSC1	activates	gene	0.60
TSC2	activates	gene	0.60
EXOSOMES	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
DEMENTIA	inhibits	gene	0.60
ALZHEIMER	activates	gene	0.60
AND	interacts_with	gene	0.60
NEURON	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
SYNAPSE	activates	gene	0.60
GENES	activates	gene	0.60
AND	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
NEURODEGENERATION	causes	gene	0.60
AND	inhibits	gene	0.60
AMYLOID	inhibits	gene	0.60
MTORC1	activates	gene	0.60
MIRNAS	expressed_in	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Trans-Synaptic Adhesion Molecule Modulation	0.544	Alzheimer's Disease	Tau propagation mechanisms and therapeut
Trans-Synaptic Adhesion Molecule Modulation	0.503	neurodegeneration	Tau propagation mechanisms and therapeut

Mentioning Analyses (2)

Scientific analyses that reference this entity

Tau propagation mechanisms and therapeutic interception points

neurodegeneration | 2026-04-04 | 15 hypotheses Top: 0.814

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

neurodegeneration | 2026-04-03 | 42 hypotheses Top: 0.910

Experiments (5)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Spp1 knockout prevents synaptic loss in AD mouse models	validation	Alzheimer's disease	0.900	0.00	Spp1 knockout AD mouse models	proposed	N/A
Adoptive transfer of TCRAβ-Tregs in AD mouse model	validation	Alzheimer's disease	0.900	0.00	transgenic mice expressing chi	proposed	N/A
AhR transcriptional regulation of NEP gene	exploratory	Alzheimer's disease	0.850	0.00	Cell culture system	proposed	N/A
Bioinformatics analysis and hub gene identification	exploratory	Alzheimer's disease	0.800	0.00	computational analysis of tran	proposed	N/A
Synaptic Vesicle Trafficking Dysfunction Validation in Parkinson's Dis	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$7,500,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
NRXN3-NLGN1 complex influences the development of depression induced by maternal [PMID:40286836]	Rong Y, Yan W, Gao Z, Yang Y, Xu C, Zhan	Brain research	2025
Membrane trafficking of synaptic adhesion molecules. [PMID:39322997]	["Bogaciu C", "Rizzoli S"]	The Journal of physiology	2025
Activation of hypothalamic-pontine-spinal pathway promotes locomotor initiation [PMID:41353490]	["Ji C", "Zhang Y", "Lin Z", "Zhao Z", "	Nature communications	2025
Molecular Signatures of Resilience to Alzheimer's Disease in Neocortical Layer 4 [PMID:39574639]	Dharshini SAP, Sanz-Ros J, Pan J, Tang W	bioRxiv : the preprint server	2024
Cross-disorder and disease-specific pathways in dementia revealed by single-cell [PMID:39265576]	Rexach JE, Cheng Y, Chen L, Polioudakis	Cell	2024
Organizing the synaptic junctions. [PMID:37060998]	["Zhou Q"]	The Journal of biological chem	2023
A Neuroligin-1 mutation associated with Alzheimer's disease produces memory and [PMID:37260747]	Arias-Aragón F, Tristán-Clavijo E, Martí	iScience	2023
Reelin through the years: From brain development to inflammation. [PMID:37339050]	Alexander A, Herz J, Calvier L	Cell reports	2023
Molecular mechanisms of synaptogenesis. [PMID:36176941]	["Qi C", "Luo L", "Feng I", "Ma S"]	Frontiers in synaptic neurosci	2022
In vivo nanoscopic landscape of neurexin ligands underlying anterograde synapse [PMID:36007521]	Nozawa K, Sogabe T, Hayashi A, Motohashi	Neuron	2022
Neuroligin-1 in brain and CSF of neurodegenerative disorders: investigation for [PMID:33522967]	Camporesi E, Lashley T, Gobom J, Lantero	Acta neuropathologica communic	2021
PSD-95 binding dynamically regulates NLGN1 trafficking and function. [PMID:31138690]	Jeong J, Pandey S, Li Y, Badger JD, Lu W	Proceedings of the National Ac	2019
NLGN1 and NLGN2 in the prefrontal cortex: their role in memory consolidation and [PMID:29278843]	Katzman A, Alberini CM	Current opinion in neurobiolog	2018
Declining levels of functionally specialized synaptic proteins in plasma neurona [PMID:29025866]	Goetzl EJ, Abner EL, Jicha GA, Kapogiann	FASEB journal : official publi	2018
Structural Insights into Modulation of Neurexin-Neuroligin Trans-synaptic Adhesi [PMID:28641111]	["Kim J", "Kim D", "Won S", "Han K", "Pa	Neuron	2017
Role of Neurexin-1β and Neuroligin-1 in Cognitive Dysfunction After Subarachnoid [PMID:26219651]	["Shen H", "Chen Z", "Wang Y", "Gao A",	Stroke	2015
Evidence for Association of Cell Adhesion Molecules Pathway and NLGN1 Polymorphi [PMID:26674772]	Zhang Z, Yu H, Jiang S, Liao J, Lu T, Wa	PloS one	2015
Neurexins. [PMID:24083347]	["Reissner C", "Runkel F", "Missler M"]	Genome biology	2013
Genetic study of neurexin and neuroligin genes in Alzheimer's disease. [PMID:23403532]	Martinez-Mir A, González-Pérez A, Gayán	Journal of Alzheimer's disease	2013
Overexpression of the cell adhesion protein neuroligin-1 induces learning defici [PMID:19437420]	["Dahlhaus R", "Hines R", "Eadie B", "Ka	Hippocampus	2010

Debates (3)

Multi-agent debates referencing this entity

Investigate prion-like spreading of tau pathology through connected brain region

closed · Rounds: 4 · Score: 0.90 · 2026-04-12

Tau propagation mechanisms and therapeutic interception points

closed · Rounds: 3 · Score: 0.95 · 2026-04-04

What gene expression changes in the aging mouse brain predict neurodegenerative

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Related Research

Hypotheses and analyses mentioning NLGN1 in their description or question text

No additional research found

NLGN1

Understanding Entity Pages

Wiki Pages (3)

Neuroligin-1 Protein

Neuroligin 1 (NLGN1)

NLGN1 Gene

Pathway Diagram

Outgoing (140)

Incoming (77)

Targeting Hypotheses (2)

Mentioning Analyses (2)

Tau propagation mechanisms and therapeutic interception points

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Experiments (5)

Related Papers (20)

Debates (3)

Investigate prion-like spreading of tau pathology through connected brain region

Tau propagation mechanisms and therapeutic interception points

What gene expression changes in the aging mouse brain predict neurodegenerative

Related Research