gene

TYROBP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TYROBP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

396Connections

5Hypotheses

8Analyses

50Outgoing

50Incoming

0Experiments

9Debates

Summary

A gene referenced in 1 knowledge graph relationship. Key connections: encodes DAP12 (protein).

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	TYROBP
Aliases	DAP12
Chromosome	19q13.12
Protein Type	Adaptor Protein
Function	is a transmembrane signaling adaptor protein that plays critical roles in innate immunity and microglial function in the central nervous system.
Primary Expression	Microglia, Monocytes, NK cells, Osteoclasts
Molecular Weight	12.1 kDa
Amino Acids	113 aa
Pathways	Innate Immunity
UniProt ID	Q9Y241
NCBI Gene ID	7305
Ensembl ID	ENSG00000111653
OMIM	605712
GeneCards	TYROBP
Human Protein Atlas	TYROBP
Associated Diseases	Aging, Als, Alzheimer, alzheimer_disease, Alzheimer's disease
Known Drugs/Compounds	BERBERINE
Interactions	AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-BETA, AND
SciDEX Hypotheses	TYROBP (DAP12) Conditional Antagonism for Early-St
KG Connections	396 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TYROBP — AlphaFold Q9Y241 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TYROBP["TYROBP"] -->|"interacts"| TREM2["TREM2"]
    TYROBP["TYROBP"] -->|"expressed in"| microglia["microglia"]
    TYROBP["TYROBP"] -->|"interacts"| Alzheimer["Alzheimer"]
    TYROBP["TYROBP"] -->|"interacts"| Ms["Ms"]
    TYROBP["TYROBP"] -->|"activates"| Als["Als"]
    TYROBP["TYROBP"] -->|"associated"| Alzheimer_1["Alzheimer"]
    RANK["RANK"] -->|"activates"| TYROBP["TYROBP"]
    GENES["GENES"] -->|"activates"| TYROBP["TYROBP"]
    APP["APP"] -->|"associated"| TYROBP["TYROBP"]
    CD33["CD33"] -->|"associated"| TYROBP["TYROBP"]
    style TYROBP fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (211)

Target	Relation	Type	Str
ds-db4a006ea647	provides_data_for	dataset	1.00
SIRPΒ1	interacts_with	receptor	0.95
Late-Onset Alzheimer's Disease	associated_with	disease	0.95
CR3	binds	receptor	0.95
Brain Homeostasis	involved_in	process	0.90
Signal Transduction	mediates	process	0.90
Pathogen Phagocytosis	regulates	process	0.90
SIRP1B	interacts_with	receptor	0.90
Gene Expression Changes	causes	phenotype	0.87
tau phosphorylation	regulates	process	0.85
Disease-Associated Microglia	regulates	phenotype	0.85
Molecular Interaction Networks	component_of	pathway	0.85
Alzheimer's Disease pathogenesis	mediates	mechanism	0.85
C1Q	regulates	protein	0.85
Alzheimer's Disease	associated_with	disease	0.85
Immune Cell Infiltration	associated_with	process	0.80
Learning Behavior	regulates	phenotype	0.80
Synaptic Function	regulates	process	0.80
Learning Behavior	involved_in	phenotype	0.75
Synaptic Function	involved_in	process	0.75
Als	activates	disease	0.75
Neurodegenerative Diseases	risk_factor_for	disease	0.75
microglia	expressed_in	cell_type	0.72
TREM2	interacts_with	protein	0.72
neuroinflammation	activates	disease	0.70
phagocytic function	modulates	mechanism	0.70
SYK	phosphorylates	gene	0.70
SYK	interacts_with	gene	0.70
DEMENTIA	increases_risk	disease	0.65
TREM2	encodes	gene	0.65
TAU	exacerbates	protein	0.65
Alzheimer	regulates	disease	0.65
Epilepsy	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Als	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Alzheimer	inhibits	disease	0.65
ALZHEIMER'S DISEASE	increases_risk	disease	0.65
DEMENTIA	interacts_with	disease	0.65
UNFOLDED PROTEIN RESPONSE	causes	pathway	0.65
CANCER	promotes	disease	0.65
MICROGLIA	promotes	cell_type	0.65
NEURODEGENERATION	mediates	disease	0.65
CANCER	activates	disease	0.65
ALZHEIMER	protects_against	disease	0.65
Alzheimer	expressed_in	disease	0.65
NLRP3	inhibits	gene	0.65
SYK	regulates	gene	0.65
STAT3	regulates	gene	0.65
STAT3	promotes	gene	0.65

Incoming (185)

Source	Relation	Type	Str
ds-db4a006ea647	data_in	dataset	1.00
TREM2	interacts_with	entity	0.90
h-trem2-f3effd21	targets_gene	hypothesis	0.90
Immune and Microglia Module	associated_with	pathway	0.89
GENES	activates	gene	0.70
MICROGLIA	regulates	cell_type	0.70
MICROGLIA	inhibits	cell_type	0.70
MICROGLIA	activates	gene	0.70
TREM2	co-expressed in	gene	0.70
CD163	activates	gene	0.70
GRN	activates	gene	0.65
NEUROINFLAMMATION	regulates	phenotype	0.65
BERBERINE	regulates	drug	0.65
BERBERINE	activates	drug	0.65
NEUROINFLAMMATION	inhibits	phenotype	0.65
NEUROINFLAMMATION	protects_against	phenotype	0.65
DAP12	interacts_with	gene	0.65
MICROGLIAL ACTIVATION	treats	phenotype	0.65
MICROGLIA	produces	cell_type	0.65
ALZHEIMER'S DISEASE	targets	disease	0.65
TREM2	associated_with	gene	0.60
OVERVIEW	interacts_with	gene	0.60
PSEN1	associated_with	gene	0.60
RANK	regulates	entity	0.60
TMEM119	associated_with	gene	0.60
AIF1	associated_with	gene	0.60
APOE	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
APP	associated_with	gene	0.60
CD33	associated_with	gene	0.60
COMPLEMENT	associated_with	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
APOE3	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
APP/PSEN1	associated_with	gene	0.60
AND	interacts_with	gene	0.60
TAUOPATHY	expressed_in	gene	0.60
PHAGOCYTOSIS	regulates	entity	0.60
PHAGOCYTOSIS	associated_with	gene	0.60
GAIN	activates	gene	0.60
STAT3	activates	gene	0.60
MMP12	activates	gene	0.60
CD33	activates	gene	0.60
ITGAM	associated_with	gene	0.60
C1QC	associated_with	gene	0.60
MICROGLIA	co_discussed	gene	0.60

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TYROBP (DAP12) Conditional Antagonism for Early-Stage Neurop	0.844	neurodegeneration	TREM2 agonism vs antagonism in DAM micro
TREM2 Signaling Bifurcation with Independent TYROBP-Independ	0.591	neuroinflammation	Why is TYROBP deficiency neuroprotective
SYK-Independent TREM2 Pathways Remain Functional in TYROBP D	0.548	neuroinflammation	Why is TYROBP deficiency neuroprotective
TYROBP Network Hyperactivation Marks Point of No Return	0.463	neurodegeneration	What is the optimal therapeutic window f
TYROBP Causal Network Inhibition for Microglial Repolarizati	0.105	neurodegeneration	Neuroinflammation Biomarker Panel for Ea

Mentioning Analyses (8)

Scientific analyses that reference this entity

Spatial Transcriptomics Analysis of Alzheimer's Disease Brain Regions

neurodegeneration | 2026-04-16 | 0 hypotheses

Why is TYROBP deficiency neuroprotective when TYROBP is an adapter for multiple

neuroinflammation | 2026-04-14 | 2 hypotheses Top: 0.591

Does SYK activation provide neuroprotection or exacerbate neuroinflammation in e

neurodegeneration | 2026-04-11 | 0 hypotheses

SEA-AD Single-Cell Analysis: Cell-Type Vulnerability in Alzheimer's Disease

neurodegeneration | 2026-04-04 | 5 hypotheses Top: 0.640

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

neurodegeneration | 2026-04-03 | 45 hypotheses Top: 0.990

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (7)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Genome-wide consensus transcriptional signatures identify synaptic pruning linki [PMID:41139712]	Li H, Xie Z, Tian Y, Zhou R, Yang Y et a	Mol Psychiatry	2026
The Alzheimer's disease risk genes MS4A4A and MS4A6A cooperate to negatively reg [PMID:41435829]	Rosner D, Sun J, Cacace R, Yee A, Wagh C	Neuron	2026
Integrative Transcriptomic and Bioinformatics Approaches Combined With Transform [PMID:41524613]	Yan D, Li W, Xing E, Wang P, Zhang Z	FASEB J	2026
Integrative bioinformatics and machine learning identify shared molecular mechan [PMID:41961800]	Deng A, Wang W	PLoS One	2026
Genome-wide consensus transcriptional signatures identify synaptic pruning linki [PMID:41139712]	Li H, Xie Z, Tian Y, Zhou R, Yang Y, Lin	Molecular psychiatry	2026
The Alzheimer's disease risk genes MS4A4A and MS4A6A cooperate to negatively reg [PMID:41435829]	Rosner D, Sun J, Cacace R, Yee A, Wagh C	Neuron	2026
Polycystic Lipomembranous Osteodysplasia with Sclerosing Leukoencephalopathy. [PMID:20301376]	Adam, Bick, Mirzaa, Pagon, Wallace et al		1993