Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PSMC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| proteasome_complex | codes_for_subunit | protein | 0.50 |
| neurodegeneration | associated_with | disease | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Early Proteasome Restoration Therapy | 0.712 | neurodegeneration | Gene expression changes in aging mouse b |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 45 hypotheses Top: 0.990
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Unveiling the Genomic Landscape of Yan Goose (Anser cygnoides): Insights into Po [PMID:41594384] | Qi S, Ai Z, Cai Y, Zhang Y, Zhao W et al | Animals (Basel) | 2026 | 0 |
| NAD+ restores proteostasis through splicing-dependent autophagy. [PMID:41313318] | Ai R, Fang EF | Autophagy | 2026 | 0 |
| CHIP and aging: a key regulator of proteostasis and cellular senescence. [PMID:40323531] | Unknown | Biogerontology | 2025 | 0 |
| Proteostasis and autophagy disruption by the aging-related VGVAPG hexapeptide - [PMID:40348194] | Unknown | Neurochemistry international | 2025 | 0 |
| A Potential Mechanism for Targeting Aggregates With Proteasomes and Disaggregase [PMID:35517053] | Unknown | Frontiers in aging neuroscienc | 2022 | 0 |
| Deciphering the Link Between ER<sup>UPR</sup> Signaling and MicroRNA in Pathogen [PMID:35615589] | Unknown | Frontiers in aging neuroscienc | 2022 | 0 |
| How autophagy can restore proteostasis defects in multiple diseases? [PMID:32043639] | Unknown | Medicinal research reviews | 2021 | 0 |
| LRSAM1 E3 ubiquitin ligase promotes proteasomal clearance of E6-AP protein. [PMID:33207262] | Unknown | Cellular signalling | 2021 | 0 |
| Amyloid toxicity in a Drosophila Alzheimer's model is ameliorated by autophagy a [PMID:34062489] | Unknown | Neurobiology of aging | 2021 | 0 |
| Clearance of the mutant androgen receptor in motoneuronal models of spinal and b [PMID:23810450] | Unknown | Neurobiology of aging | 2014 | 0 |
Multi-agent debates referencing this entity