gene

C4B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about C4B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

197Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

Complement component C4B gene - role in immune function, neuroinflammation, and connection to neurodegenerative and autoimmune diseases

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	C4B
Full Name	Complement Component 4B (Chido/Rodgers Blood Group)
Aliases	Complement component C4B gene
Chromosome	6p21.3
Target Class	Protein
Function	encodes a crucial protein in the complement cascade, sharing significant sequence similarity with its close relative C4A while exhibiting distinct biochemical properties and disease associations.
Mechanism of Action	Prioritized from 1 SciDEX hypotheses, including: Age-Dependent Complement C4b Upregulation Drives Synaptic Vulnerability in Hippocampal CA1 Neurons
Druggability	Undruggable (0.23)
Molecular Weight	104 kDa
Amino Acids	1741 aa
Pathways	Complement
UniProt ID	P0C0S0
NCBI Gene ID	713
Ensembl ID	ENSG00000244731
OMIM	120820
GeneCards	C4B
Human Protein Atlas	C4B
Associated Diseases	Aging, Als, Alzheimer, neurodegeneration
Interactions	AND, AXON, C1Q, C1QA, C3, C4
SciDEX Target	View Target Profile
KG Connections	197 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: C4B — AlphaFold P0C0S0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

C4B Gene

gene · 1977 words

→

C4B Protein

protein · 665 words

→

Pathway Diagram

graph TD
    C4B["C4B"]
    Alzheimer{"Alzheimer"}
    C4B -->|"associated with"| Alzheimer
    Ms{"Ms"}
    C4B -->|"expressed in"| Ms
    Schizophrenia{"Schizophrenia"}
    C4B -->|"expressed in"| Schizophrenia
    Als{"Als"}
    C4B -->|"expressed in"| Als
    C4B -->|"associated with"| Als
    Tumor{"Tumor"}
    C4B -->|"regulates"| Tumor
    Inflammation{"Inflammation"}
    C4B -->|"expressed in"| Inflammation
    ALS{"ALS"}
    C4B -->|"expressed in"| ALS
    Complement(["Complement"])
    C4B -->|"expressed in"| Complement
    JUN["JUN"]
    C4B -->|"associated with"| JUN
    TREM2["TREM2"]
    C4B -->|"associated with"| TREM2
    GENES["GENES"]
    C4B -->|"expressed in"| GENES
    JUN -->|"associated with"| C4B
    TREM2 -->|"associated with"| C4B
    C4A["C4A"]
    C4A -->|"expressed in"| C4B
    COMPLEMENT["COMPLEMENT"]
    COMPLEMENT -->|"regulates"| C4B
    CYTOKINES["CYTOKINES"]
    CYTOKINES -->|"activates"| C4B
    TNF["TNF"]
    TNF -->|"expressed in"| C4B
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"expressed in"| C4B
    IL_6["IL-6"]
    IL_6 -->|"activates"| C4B
    DISEASE_ASSOCIATED_MICROGLIA["DISEASE-ASSOCIATED MICROGLIA"]
    DISEASE_ASSOCIATED_MICROGLIA -->|"associated with"| C4B
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"associated with"| C4B
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"associated with"| C4B
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"associated with"| C4B
    style C4B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (120)

Target	Relation	Type	Str
COMPLEMENT_CASCADE	component_of	pathway	0.95
SYNAPTIC_PRUNING	mediates	process	0.90
C3	activates	gene	0.90
C1QA	pathway_partner	gene	0.90
SCHIZOPHRENIA	risk_gene_for	disease	0.90
AGING	associated_with	process	0.85
HIPPOCAMPUS	upregulated_in	brain_region	0.85
ALZHEIMER'S DISEASE	upregulated_in	disease	0.85
MICROGLIA	associated_with	cell_type	0.80
INTERFERON_GAMMA	induced_by	cytokine	0.80
CD46	regulated_by	protein	0.80
CD55	regulated_by	protein	0.80
PRC2	repressed_by	complex	0.75
TAU	pathology_linked_to	protein	0.75
SUTIMLIMAB	therapeutic_target_of	drug	0.70
Classical complement cascade	participates_in	pathway	0.68
neurodegeneration	associated_with	disease	0.68
Neuroinflammation	activates	disease	0.65
Ms	activates	disease	0.65
Neuropathy	activates	disease	0.65
Inflammation	activates	disease	0.65
Autoimmune	activates	disease	0.65
Als	associated_with	disease	0.65
ALS	expressed_in	disease	0.65
Tumor	regulates	disease	0.65
Als	interacts_with	disease	0.65
Inflammation	expressed_in	disease	0.65
Alzheimer	associated_with	disease	0.65
Ms	expressed_in	disease	0.65
Aging	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Schizophrenia	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Depression	activates	disease	0.65
GENES	associated_with	gene	0.60
COMPLEMENT	biomarker_for	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
Complement	biomarker_for	pathway	0.60
AMYLOID	associated_with	gene	0.60
Amyloid	associated_with	pathway	0.60
RNA	associated_with	gene	0.60
AND	associated_with	gene	0.60
AND	expressed_in	gene	0.60
SYNAPSE	activates	gene	0.60
Interferon	activates	protein	0.60
Cytokine	activates	protein	0.60
INOS	biomarker_for	gene	0.60
oxidative stress	activates	process	0.60
Oligodendrocyte	associated_with	cell_type	0.60

Incoming (77)

Source	Relation	Type	Str
h-2f43b42f	targets	hypothesis	0.90
TREM2	associated_with	gene	0.60
C4A	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
NMNAT2	activates	gene	0.60
C4	interacts_with	gene	0.60
C4A	interacts_with	gene	0.60
COMPLEMENT	expressed_in	gene	0.60
JUN	associated_with	gene	0.60
GENES	expressed_in	gene	0.60
AMYLOID	encodes	gene	0.60
CYTOKINES	activates	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
IL-6	activates	gene	0.60
ASTROCYTE	associated_with	gene	0.60
SYNAPSE	expressed_in	gene	0.60
RNA	encodes	gene	0.60
COMPLEMENT	regulates	gene	0.60
RNA	associated_with	gene	0.60
AND	associated_with	gene	0.60
IRF8	associated_with	gene	0.60
AND	expressed_in	gene	0.60
PHAGOCYTOSIS	associated_with	gene	0.60
COMPLEMENT	biomarker_for	gene	0.60
MICROGLIA	biomarker_for	gene	0.60
ASTROCYTE	expressed_in	gene	0.60
AMYLOID	associated_with	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
ASTROCYTES	associated_with	gene	0.60
DEPRESSION	activates	gene	0.60
COMPLEMENT	activates	gene	0.60
IFN	activates	gene	0.60
RNA	activates	gene	0.60
MICROGLIA	activates	gene	0.60
SYNAPSE	activates	gene	0.60
OXIDATIVE STRESS	biomarker_for	gene	0.60
AGING	associated_with	gene	0.60
INOS	biomarker_for	gene	0.60
AND	biomarker_for	gene	0.60
SYNAPSE	associated_with	gene	0.60
GENES	associated_with	gene	0.60
PRESENILIN	associated_with	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
GENES	activates	gene	0.60
SYNAPTIC PRUNING	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
ITGAM	biomarker_for	gene	0.60
C1QA	biomarker_for	gene	0.60
GFAP	expressed_in	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

neurodegeneration | 2026-04-03 | 42 hypotheses Top: 0.910

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What gene expression changes in the aging mouse brain predict neurodegenerative

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Related Research

Hypotheses and analyses mentioning C4B in their description or question text

No additional research found