concept

CLDN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CLDN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

307Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

CLDN1 is a concept in neurodegeneration research. Key relationships include: therapeutic target, expressed in, activates. Associated with ALS, Als, Atherosclerosis. Connected to 146 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	CLDN1
Key Genes/Proteins	AADC, ABCB1, AHR, ALDH1A1, AND, APC
Related Diseases	Als, ALS, ALZHEIMER, anxiety, Atherosclerosis

🔮 Predicted Structure: CLDN1 — AlphaFold O95832 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

graph TD
    CLDN1["CLDN1"]
    CLDN1 -->|"activates"| Ms["Ms"]
    CLDN1 -->|"activates"| Inflammation["Inflammation"]
    CLDN1 -->|"inhibits"| Als["Als"]
    CLDN1 -->|"target for"| Fibrosis["Fibrosis"]
    CLDN1 -->|"target for"| Hepatitis["Hepatitis"]
    CLDN1 -->|"target for"| Carcinoma["Carcinoma"]
    CLDN1 -->|"target for"| Cancer["Cancer"]
    h_6c83282d["h-6c83282d"] -->|"targets"| CLDN1
    IL4["IL4"] -->|"inhibits"| CLDN1
    IL13["IL13"] -->|"inhibits"| CLDN1
    OCLN["OCLN"] -->|"activates"| CLDN1
    TNF["TNF"] -->|"activates"| CLDN1
    FGF20["FGF20"] -->|"target for"| CLDN1
    BRG1["BRG1"] -->|"target for"| CLDN1
    NRCAM["NRCAM"] -->|"target for"| CLDN1
    NOTCH2["NOTCH2"] -->|"target for"| CLDN1
    EP300["EP300"] -->|"target for"| CLDN1

Outgoing (211)

Target	Relation	Type	Str
EPHA2	interacts_with	protein	0.95
chemoresistance	promotes	phenotype	0.95
cancer stemness	promotes	phenotype	0.95
EPHA2	inhibits	protein	0.90
Glioma Progression	downregulates	process	0.85
Epidermal Barrier Function	associated_with	phenotype	0.85
OCLN	associated_with	gene	0.80
Glioma	downregulates	disease	0.80
Cancer	therapeutic_target	disease	0.75
Hepatitis	therapeutic_target	disease	0.75
Carcinoma	therapeutic_target	disease	0.75
Hepatocellular Carcinoma	therapeutic_target	disease	0.75
blood-brain barrier integrity	mediates	phenotype	0.75
Glioblastoma Multiforme	suppresses	disease	0.70
Glioblastoma Multiforme	biomarker_for	disease	0.70
neural stem cells	regulates	cell_type	0.70
neural stem cells	inhibits	cell_type	0.70
Liver Cancer	therapeutic_target	disease	0.65
Colorectal Cancer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	activates	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Ms	activates	disease	0.65
Prostate Cancer	therapeutic_target	disease	0.65
Infection	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
Lung Cancer	therapeutic_target	disease	0.65
Pulmonary Fibrosis	therapeutic_target	disease	0.65
Pancreatic Cancer	therapeutic_target	disease	0.65
Gastric Cancer	therapeutic_target	disease	0.65
Fibrosis	activates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Atherosclerosis	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
Hepatitis	regulates	disease	0.65
Cirrhosis	therapeutic_target	disease	0.65
ALS	inhibits	disease	0.65
Als	expressed_in	disease	0.65
IL-13	expressed_in	gene	0.60
unfolded protein response	participates_in	pathway	0.60
ROS	inhibits	gene	0.60
CLDN4	regulates	gene	0.60
CLDN4	inhibits	gene	0.60
oxidative stress response	participates_in	pathway	0.60
cancer	associated_with	disease	0.60
INFLAMMATION	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60

Incoming (96)

Source	Relation	Type	Str
Betulinic Acid	upregulates	compound	0.95
h-6c83282d	targets	hypothesis	0.90
Tralokinumab	upregulates	drug	0.88
Gallic Acid	upregulates	compound	0.88
IL4	inhibits	protein	0.72
IL13	inhibits	protein	0.72
CANCER	therapeutic_target	gene	0.70
RNA	expressed_in	gene	0.60
IL4R	expressed_in	gene	0.60
IL-13	expressed_in	gene	0.60
IL-4	inhibits	gene	0.60
IL-13	inhibits	gene	0.60
PPAR	activates	gene	0.60
CDH1	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
OCLN	activates	gene	0.60
TNF	activates	gene	0.60
AHR	inhibits	gene	0.60
ARNT	inhibits	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
CCND1	targets	gene	0.60
S100A9	expressed_in	gene	0.60
IFNG	expressed_in	gene	0.60
S100A8	expressed_in	gene	0.60
IL22	expressed_in	gene	0.60
INFLAMMATION	activates	gene	0.60
IL31	expressed_in	gene	0.60
CCL26	expressed_in	gene	0.60
CYTOKINES	inhibits	gene	0.60
CLDN4	expressed_in	gene	0.60
FGF20	therapeutic_target	gene	0.60
BRG1	therapeutic_target	gene	0.60
NRCAM	therapeutic_target	gene	0.60
NOTCH2	therapeutic_target	gene	0.60
EP300	therapeutic_target	gene	0.60
CTNNB1	therapeutic_target	gene	0.60
NEUROD1	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
FOXM1	therapeutic_target	gene	0.60
LEF1	therapeutic_target	gene	0.60
SMARCA4	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
FZD7	therapeutic_target	gene	0.60
JAG1	therapeutic_target	gene	0.60
MITF	therapeutic_target	gene	0.60
GAIN	therapeutic_target	gene	0.60
FGF18	therapeutic_target	gene	0.60
IL10	therapeutic_target	gene	0.60
DKK1	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 5 hypotheses Top: 0.720

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.888

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

This analysis aims to elucidate the mechanisms by which gut microbiome dysbiosis

closed · Rounds: 4 · Score: 0.82 · 2026-04-22

What are the mechanisms underlying what are the mechanisms by which gut microbio

closed · Rounds: 4 · Score: 0.95 · 2026-04-01

Related Research

Hypotheses and analyses mentioning CLDN1 in their description or question text

No additional research found