protein

IL-10

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL-10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

730Connections

2Hypotheses

1Analyses

50Outgoing

50Incoming

1Experiments

3Debates

Summary

Interleukin-10 (IL-10) — an anti-inflammatory cytokine that modulates neuroinflammation in Alzheimer's and Parkinson's disease through JAK-STAT3 signaling.

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🔬 Protein Info

Gene Symbol	IL
Function	Interleukin-1 beta (IL-1β) is a potent pro-inflammatory cytokine that plays a central role in the innate immune response and neuroinflammation.
GeneCards	IL
Human Protein Atlas	IL
Associated Diseases	CRC
KG Connections	1 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

IL-10 Protein

protein · 2632 words

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Pathway Diagram

graph TD
    IL10["IL-10"]
    S1P1["S1P1 Receptor"]
    TNF["TNF-alpha"]
    IL6["IL-6"]
    AKT["AKT"]
    NRF2["Nrf2"]
    MICROGLIA["Microglia"]
    NEUROINFLAM["Neuroinflammation"]
    INFLAM["Inflammation"]
    SPHINGO["Sphingolipid Metabolism"]
    APOPTOSIS["Apoptosis"]
    ALZHEIMER["Alzheimer's Disease"]
    PARKINSON["Parkinson's Disease"]
    AMYLOID["Amyloid Beta"]
    LRRK2["LRRK2"]
    PARKIN["Parkin"]

    S1P1 -->|"upregulates"| IL10
    AKT -->|"promotes"| IL10
    NRF2 -->|"enhances"| IL10
    MICROGLIA -->|"produces"| IL10
    
    TNF -->|"inhibits"| IL10
    IL6 -->|"inhibits"| IL10
    AMYLOID -->|"suppresses"| IL10
    
    IL10 -->|"inhibits"| NEUROINFLAM
    IL10 -->|"suppresses"| INFLAM
    IL10 -->|"regulates"| SPHINGO
    IL10 -->|"protects against"| APOPTOSIS
    
    NEUROINFLAM -->|"contributes to"| ALZHEIMER
    NEUROINFLAM -->|"contributes to"| PARKINSON
    LRRK2 -->|"associated with"| PARKINSON
    PARKIN -->|"associated with"| PARKINSON
    
    style IL10 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    style S1P1 fill:#1b5e20,stroke:#333,stroke-width:2px
    style AKT fill:#4a1a6b,stroke:#333,stroke-width:2px
    style NRF2 fill:#4a1a6b,stroke:#333,stroke-width:2px
    style TNF fill:#ef5350,stroke:#333,stroke-width:2px
    style IL6 fill:#ef5350,stroke:#333,stroke-width:2px
    style NEUROINFLAM fill:#ef5350,stroke:#333,stroke-width:2px
    style INFLAM fill:#ef5350,stroke:#333,stroke-width:2px
    style ALZHEIMER fill:#7d4200,stroke:#333,stroke-width:2px
    style PARKINSON fill:#7d4200,stroke:#333,stroke-width:2px
    style MICROGLIA fill:#1b5e20,stroke:#333,stroke-width:2px

Outgoing (472)

Target	Relation	Type	Str
Inflammation	inhibits	process	0.95
Sphingolipid Metabolism	inhibits	pathway	0.95
Sphingolipid Metabolism	modulates	pathway	0.90
Sphingolipids	regulates	compound	0.90
microglia	expressed_in	cell_type	0.85
TGF	activates	gene	0.85
unfolded protein response	participates_in	pathway	0.85
TGF-beta signaling	participates_in	pathway	0.85
neurotrophin signaling	participates_in	pathway	0.85
sphingolipid metabolism	associated_with	process	0.80
Psoriasis	associated_with	disease	0.80
inflammation	associated_with	disease	0.80
MACROPHAGES	activates	cell_type	0.80
Neuroinflammation	inhibits	process	0.80
NF-kB signaling	participates_in	pathway	0.75
astrocytes	expressed_in	cell_type	0.75
MONOCYTE	promotes	cell_type	0.65
Ms	causes	disease	0.65
MACROPHAGE	promotes	cell_type	0.65
TGF	biomarker_for	gene	0.65
Inflammation	causes	disease	0.65
Stroke	activates	disease	0.65
oxidative stress response	participates_in	pathway	0.65
TNF	inhibits	gene	0.65
Tumor	degrades	disease	0.65
Multiple Sclerosis	expressed_in	disease	0.65
TNF	causes	gene	0.65
TNF	biomarker_for	gene	0.65
IL-6	causes	gene	0.65
Als	expressed_in	disease	0.65
ROS	causes	gene	0.65
Inflammation	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
MICROGLIA	associated_with	cell_type	0.65
Inflammation	associated_with	disease	0.65
ALS	inhibits	disease	0.65
Aging	therapeutic_target	disease	0.65
Inflammation	expressed_in	disease	0.65
Stroke	inhibits	disease	0.65
neuroinflammation	activates	disease	0.65
Multiple Sclerosis	biomarker_for	disease	0.65
Ms	activates	disease	0.65
Als	regulates	disease	0.65
Neuroinflammation	biomarker_for	disease	0.65
Neurodegeneration	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Parkinson	expressed_in	disease	0.65
Glioblastoma	activates	disease	0.65
Lymphoma	activates	disease	0.65

Incoming (258)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	0.98
LRWE	upregulates	compound	0.90
TNF	inhibits	gene	0.90
32505187	was reduced in	paper	0.90
S1P1	upregulates	receptor	0.85
MICROGLIA	associated_with	cell_type	0.82
IL-6	inhibits	gene	0.82
AMYLOID	associated_with	protein	0.82
PARKINSON'S DISEASE	associated_with	disease	0.82
IL-6	associated_with	gene	0.82
DHT	upregulates	compound	0.80
TREM2	regulated_by	gene	0.78
DHT	modulates	compound	0.75
CD68	activates	gene	0.75
GDNF	activates	gene	0.75
MICROGLIA	inhibits	cell_type	0.74
TNF	activates	gene	0.66
IL-6	activates	gene	0.66
TNF	associated_with	gene	0.66
HDAC	activates	gene	0.65
ASTROCYTES	promotes	cell_type	0.65
CD38	promotes	gene	0.65
GFAP	promotes	gene	0.65
ASTROCYTE	promotes	cell_type	0.65
CREB	activates	gene	0.65
CX3CR1	regulates	gene	0.65
BDNF	causes	gene	0.65
ATP	interacts_with	gene	0.65
NF-KB	associated_with	protein	0.64
BAX	associated_with	gene	0.64
AKT	associated_with	gene	0.64
P2X7	activates	gene	0.60
GAIN	regulates	gene	0.60
IL1R1	activates	gene	0.60
SYK	inhibits	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
AKT	inhibits	gene	0.60
IL-1	associated_with	gene	0.60
NLRP3	associated_with	gene	0.60
ATP	activates	gene	0.60
ASC	activates	gene	0.60
COMPLEMENT	activates	gene	0.60
CD68	expressed_in	gene	0.60
LRRK2	activates	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
NAD	inhibits	gene	0.60
NAMPT	inhibits	gene	0.60
CD38	activates	gene	0.60
SIRT6	inhibits	gene	0.60
PARP1	inhibits	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
IL-10-Producing B10 Cells Establish AQP4-Specific Peripheral	0.648	neuroinflammation	How do B cells mechanistically orchestra
CCR2+ Monocyte Reprogramming via IL-10 Enhancement for CNS I	0.000	immunomics	Systemic immune profiling in neurodegene