concept

IL-13

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL-13: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

155Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	IL-13
Key Genes/Proteins	AHR, Albumin, ALZHEIMER, ALZHEIMER'S DISEASE, ARNT, Aβ
Related Diseases	Als, ALS, Alzheimer, Atherosclerosis, Atopic Dermatitis

Pathway Diagram

graph TD
    IL_13["IL-13"]
    style IL_13 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    IL_13 -->|"causes"| Atopic_Dermatitis["Atopic Dermatitis"]
    IL_13 -->|"mediates"| Type_2_Inflammation["Type 2 Inflammation"]
    IL_13 -->|"upregulates"| Npy1r([Npy1r])
    IL_13 -->|"activates"| JAK_STAT6["JAK/STAT6"]
    IL_13 -->|"activates"| INFLAMMATION["INFLAMMATION"]
    IL_13 -->|"activates"| Inflammation["Inflammation"]
    IL_13 -.->|"inhibits"| ALS["ALS"]
    IL_13 -.->|"inhibits"| Als["Als"]
    IL_13 -->|"expressed in"| Atherosclerosis["Atherosclerosis"]
    Tralokinumab{"Tralokinumab"} -.->|"inhibits"| IL_13
    IL_10([IL-10]) -->|"activates"| IL_13
    INFLAMMATION -->|"activates"| IL_13
    MITOCHONDRIAL_DYSFUNCTION([MITOCHONDRIAL DYSFUNCTION]) -->|"activates"| IL_13
    AND([AND]) -->|"activates"| IL_13
    MIRO1([MIRO1]) -->|"activates"| IL_13
    CLDN1([CLDN1]) -.->|"inhibits"| IL_13
    ARNT([ARNT]) -->|"activates"| IL_13
    AHR([AHR]) -->|"activates"| IL_13
    NRF2([NRF2]) -->|"activates"| IL_13

Outgoing (105)

Target	Relation	Type	Str
Atopic Dermatitis	causes	disease	0.90
Type 2 Inflammation	mediates	process	0.90
Npy1r	upregulates	gene	0.85
JAK/STAT6	activates	pathway	0.85
Als	regulates	disease	0.65
Parkinson	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	causes	disease	0.65
ALS	causes	disease	0.65
ALS	inhibits	disease	0.65
Als	causes	disease	0.65
Alzheimer	activates	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Als	expressed_in	disease	0.65
Atherosclerosis	expressed_in	disease	0.65
ALS	regulates	disease	0.65
ALS	expressed_in	disease	0.65
Inflammation	biomarker_for	disease	0.65
Inflammation	activates	disease	0.65
Als	inhibits	disease	0.65
Rb	inhibits	protein	0.60
RNA	expressed_in	gene	0.60
S100A9	expressed_in	gene	0.60
Interleukin	expressed_in	protein	0.60
Caspase	activates	protein	0.60
Aβ	activates	protein	0.60
Cytokine	regulates	protein	0.60
Il-1	inhibits	protein	0.60
Tgf-Β	activates	pathway	0.60
OCLN	expressed_in	gene	0.60
CLDN1	inhibits	gene	0.60
CYTOKINES	inhibits	gene	0.60
AHR	activates	gene	0.60
ARNT	activates	gene	0.60
JAK	inhibits	gene	0.60
CLDN4	expressed_in	gene	0.60
STAT6	activates	gene	0.60
IL22	expressed_in	gene	0.60
IL4R	expressed_in	gene	0.60
TNF	activates	gene	0.60
INOS	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
TNF-Α	activates	gene	0.60
TLR4	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
Il-1	causes	protein	0.60
CLDN1	expressed_in	gene	0.60
S100A8	expressed_in	gene	0.60
GENES	biomarker_for	gene	0.60

Incoming (50)

Source	Relation	Type	Str
Tralokinumab	inhibits	drug	0.95
PNS-R1	downregulates	compound	0.90
DHT	upregulates	compound	0.80
DHT	modulates	compound	0.75
IL4R	expressed_in	gene	0.60
S100A9	expressed_in	gene	0.60
IL31	expressed_in	gene	0.60
IFNG	expressed_in	gene	0.60
IL22	expressed_in	gene	0.60
RNA	expressed_in	gene	0.60
ALZHEIMER	activates	gene	0.60
CLDN1	inhibits	gene	0.60
ARNT	activates	gene	0.60
AHR	activates	gene	0.60
NRF2	activates	gene	0.60
CYTOKINES	inhibits	gene	0.60
STAT6	activates	gene	0.60
IL-4	inhibits	gene	0.60
CLDN4	expressed_in	gene	0.60
ROS	activates	gene	0.60
JAK	inhibits	gene	0.60
OCLN	expressed_in	gene	0.60
IRF7	inhibits	gene	0.60
GENES	biomarker_for	gene	0.60
INFLAMMATION	biomarker_for	gene	0.60
CLDN1	expressed_in	gene	0.60
S100A8	expressed_in	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
NF-ΚB	activates	gene	0.60
INOS	activates	gene	0.60
IL-10	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
MIRO1	activates	gene	0.60
NPY	causes	gene	0.60
IL-1	causes	gene	0.60
RNA	causes	gene	0.60
NPY1R	causes	gene	0.60
INFLAMMATION	causes	gene	0.60
STAT6	causes	gene	0.60
JAK	causes	gene	0.60
BCL-2	activates	gene	0.60
MAPK	activates	gene	0.60
IL-1	regulates	gene	0.60
MICROGLIA	activates	gene	0.60
P38	activates	gene	0.60
CYTOKINES	regulates	protein	0.35
IL-10	regulates	gene	0.35
BDNF	causes	gene	0.35
CYTOKINES	causes	protein	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IL-13 in their description or question text

No additional research found