protein

YTHDF2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about YTHDF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

75Connections

0Hypotheses

1Analyses

19Outgoing

50Incoming

0Experiments

2Debates

No summary available yet.

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🔬 Protein Info

Gene Symbol	YTHDF2
GeneCards	YTHDF2
Human Protein Atlas	YTHDF2
Associated Diseases	glioblastoma cell proliferation, glioblastoma invasion
Known Drugs/Compounds	N6-Methyladenosine, rapamycin
Interactions	AKT, ALS, AMBRA1, AMPK, APC, APP
KG Connections	75 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    YTHDF2["YTHDF2"] -->|"binds"| m6A_Modification["m6A Modification"]
    style m6A_Modification fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    YTHDF2["YTHDF2"] -.->|"inhibits"| ATG5["ATG5"]
    style ATG5 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    YTHDF2["YTHDF2"] -.->|"inhibits"| ATG7["ATG7"]
    style ATG7 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    YTHDF2["YTHDF2"] -.->|"inhibits"| LXRA_mRNA["LXRA mRNA"]
    style LXRA_mRNA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    YTHDF2["YTHDF2"] -.->|"inhibits"| HIVEP2_mRNA["HIVEP2 mRNA"]
    style HIVEP2_mRNA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    YTHDF2["YTHDF2"] -->|"associated"| glioblastoma_cell_proliferatio["glioblastoma cell proliferation"]
    style glioblastoma_cell_proliferatio fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    YTHDF2["YTHDF2"] -->|"associated"| glioblastoma_invasion["glioblastoma invasion"]
    style glioblastoma_invasion fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    ERK["ERK"] -->|"phosphorylates"| YTHDF2["YTHDF2"]
    style ERK fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    EGFR_SRC_ERK_pathway["EGFR/SRC/ERK pathway"] -->|"associated"| YTHDF2["YTHDF2"]
    style EGFR_SRC_ERK_pathway fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    FMDV_VP1["FMDV VP1"] -.->|"inhibits"| YTHDF2["YTHDF2"]
    style FMDV_VP1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    style YTHDF2 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (19)

Target	Relation	Type	Str
m6A Modification	binds	process	0.95
N6-Methyladenosine	binds	compound	0.95
stress granules	localizes_to	process	0.90
LXRA mRNA	inhibits	gene	0.90
HIVEP2 mRNA	inhibits	gene	0.90
ATG7	inhibits	protein	0.90
ATG5	inhibits	protein	0.90
glioblastoma invasion	associated_with	phenotype	0.80
glioblastoma cell proliferation	associated_with	phenotype	0.80
cholesterol homeostasis	inhibits	phenotype	0.80
glioblastoma	expressed_in	disease	0.60
glioblastoma	activates	disease	0.60
Wnt signaling	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
pyroptosis	participates_in	pathway	0.60
Parkinson's disease	activates	disease	0.60
epigenetic regulation	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.55
microglia	expressed_in	cell_type	0.55

Incoming (56)

Source	Relation	Type	Str
ERK	phosphorylates	protein	0.90
EGFR/SRC/ERK pathway	associated_with	pathway	0.90
FMDV VP1	inhibits	protein	0.90
FMDV VP1	interacts_with	protein	0.90
FMDV VP1	cleaves	protein	0.85
RNA	activates	gene	0.80
NLRP3	activates	gene	0.60
GSDMD	activates	gene	0.60
HDAC5	activates	gene	0.60
TNF	activates	gene	0.60
WTAP	activates	gene	0.60
METTL3	associated_with	gene	0.60
PPARGC1A	associated_with	gene	0.60
ALS	interacts_with	gene	0.60
WTAP	associated_with	gene	0.60
AMBRA1	activates	gene	0.60
AMPK	activates	gene	0.60
APP	activates	gene	0.60
AR	activates	gene	0.60
ATG	activates	gene	0.60
ATP6AP2	activates	gene	0.60
BCL2	activates	gene	0.60
BCL2L1	activates	gene	0.60
BECN1	activates	gene	0.60
CTSD	activates	gene	0.60
CYP19A1	activates	gene	0.60
ESR1	activates	gene	0.60
ESR2	activates	gene	0.60
FYCO1	activates	gene	0.60
GABA	activates	gene	0.60
GABARAP	activates	gene	0.60
GLA	activates	gene	0.60
HDAC6	activates	gene	0.60
LAMP2	activates	gene	0.60
LC3B	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
MTOR	activates	gene	0.60
PIK3C3	activates	gene	0.60
PSEN1	activates	gene	0.60
PSEN2	activates	gene	0.60
RAB9A	activates	gene	0.60
RAS	activates	gene	0.60
SOX9	activates	gene	0.60
TFEB	activates	gene	0.60
ULK1	activates	gene	0.60
UVRAG	activates	gene	0.60
VDAC2	activates	gene	0.60
WDR45	activates	gene	0.60
rapamycin	targets	drug	0.60
GBM	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What determines the specificity of RNA-protein interactions that drive distinct

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.712

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Debate: Liquid-to-Solid Transition Pathology Reveals Granule Weak Points

closed · Rounds: 4 · Score: 0.58 · 2026-04-27

While the study identifies G3BP1 as a central node triggering phase separation,

closed · Rounds: 4 · Score: 0.76 · 2026-04-21

Related Research

Hypotheses and analyses mentioning YTHDF2 in their description or question text

No additional research found