gene

HDAC5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HDAC5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

76Connections

0Hypotheses

0Analyses

50Outgoing

23Incoming

0Experiments

0Debates

Summary

HDAC5 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, inhibits. Associated with Als, Cancer, Carcinoma. Connected to 27 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	HDAC5
Chromosome	17q21.31
Protein Family	Class IIa histone deacetylases
Function	Histone deacetylation: HDAC5 deacetylates histone H3 and H4 tails, creating a chromatin environment that suppresses transcription
Primary Expression	the brain, where it plays critical roles in synaptic plasticity, memory formation, stress responses, and n
Subcellular Localization	Nucleus (basal) and cytoplasm (signal-dependent)
Molecular Weight	112 kDa
Amino Acids	1122 aa
Pathways	NF-κB
UniProt ID	Q9UQL6
GeneCards	HDAC5
Human Protein Atlas	HDAC5
Associated Diseases	Alzheimer's disease, Parkinson's disease, Huntington's disease
Interactions	AKT, AND, BIN1, BMP2, CANCER, FERROPTOSIS
KG Connections	76 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: HDAC5 — AlphaFold Q9UQL6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    HDAC5["HDAC5"]
    Cancer{"Cancer"}
    HDAC5 -->|"activates"| Cancer
    Carcinoma{"Carcinoma"}
    HDAC5 -->|"activates"| Carcinoma
    Tumor{"Tumor"}
    HDAC5 -->|"activates"| Tumor
    STAT6["STAT6"]
    HDAC5 -->|"regulates"| STAT6
    HDAC5 -->|"activates"| STAT6
    Ferroptosis(["Ferroptosis"])
    HDAC5 -->|"activates"| Ferroptosis
    SLC7A11["SLC7A11"]
    HDAC5 -->|"activates"| SLC7A11
    TRIM28["TRIM28"]
    HDAC5 -->|"activates"| TRIM28
    FERROPTOSIS["FERROPTOSIS"]
    HDAC5 -->|"activates"| FERROPTOSIS
    CANCER["CANCER"]
    HDAC5 -->|"activates"| CANCER
    neurodegeneration["neurodegeneration"]
    HDAC5 -->|"implicated in"| neurodegeneration
    SIK1["SIK1"]
    SIK1 -->|"activates"| HDAC5
    SLC7A11 -->|"activates"| HDAC5
    CANCER -->|"activates"| HDAC5
    FERROPTOSIS -->|"activates"| HDAC5
    TRIM28 -->|"activates"| HDAC5
    STAT6 -->|"activates"| HDAC5
    AND["AND"]
    AND -->|"activates"| HDAC5
    TRIM28 -->|"inhibits"| HDAC5
    style HDAC5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (53)

Target	Relation	Type	Str
STAT6	associated_with	gene	0.90
Tumor Progression	involved_in	process	0.90
tumor progression	drives	process	0.85
epigenetic regulation	participates_in	pathway	0.70
Als	activates	disease	0.65
ALS	expressed_in	disease	0.65
Carcinoma	activates	disease	0.65
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
STAT6	regulates	protein	0.64
SIK1	associated_with	gene	0.60
TRIM28	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
CANCER	activates	gene	0.60
Epithelial-Mesenchymal Transition	activates	pathway	0.60
Pi3K/Akt	regulates	pathway	0.60
Tgf-Β	inhibits	pathway	0.60
SIK1	activates	gene	0.60
AND	activates	gene	0.60
LIF	activates	gene	0.60
Ferroptosis	activates	pathway	0.60
ferroptosis	participates_in	pathway	0.60
HDAC7	interacts_with	gene	0.60
SIK1	targets	gene	0.60
Pi3K	regulates	pathway	0.60
SLC7A11	activates	gene	0.60
Akt	inhibits	pathway	0.60
TGF-beta signaling	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.60
STAT6	activates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
WTAP	activates	gene	0.60
YTHDF2	activates	gene	0.60
Raf	activates	protein	0.60
TNF	activates	gene	0.60
HDAC9	associated_with	gene	0.60
HDAC9	inhibits	gene	0.60
HDAC9	activates	gene	0.60
NRF2	activates	gene	0.60
TRIM28	phosphorylates	entity	0.60
Epigenetic	activates	pathway	0.60
SLC7A11	regulates	entity	0.60
Stem Cell	expressed_in	cell_type	0.55
HDAC9	co_expressed_with	gene	0.50
NRF2	co_expressed_with	gene	0.50
WAS	activates	protein	0.50
SLC7A1	co_discussed	gene	0.50
STING	co_discussed	gene	0.50
TRIM2	co_discussed	gene	0.50
cancer	activates	disease	0.50

Incoming (23)

Source	Relation	Type	Str
SIK1	phosphorylates	gene	0.95
SIK1	activates	protein	0.72
LIF	expressed_in	gene	0.60
AND	inhibits	gene	0.60
HDAC	inhibits	gene	0.60
SLC7A11	activates	gene	0.60
PTEN	regulates	gene	0.60
HK2	inhibits	gene	0.60
PI3K	regulates	gene	0.60
AKT	inhibits	gene	0.60
BIN1	interacts_with	gene	0.60
BIN1	expressed_in	gene	0.60
BIN1	associated_with	gene	0.60
METTL3	activates	gene	0.60
HDAC11	interacts_with	gene	0.60
HDAC3	interacts_with	gene	0.60
BMP2	activates	gene	0.60
CANCER	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
HDAC	activates	gene	0.60
TRIM28	activates	gene	0.60
STAT6	activates	gene	0.60
TRIM28	inhibits	protein	0.56

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HDAC5 in their description or question text

No additional research found