Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about lysosomal_biogenesis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
A mechanism referenced in 1 knowledge graph relationship. Key connections: TFEB (protein) promotes.
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| Name | lysosomal_biogenesis |
| Key Genes/Proteins | C9ORF72, MCOLN1, TFEB |
| Linked Hypotheses | 8 hypotheses |
flowchart TD
N0["LYSOSOMAL BIOGENESIS"]
N1["C9ORF72"]
N1 -->|"regulates"| N0
N2["AUTOPHAGY"]
N0 -->|"regulates"| N2
N3["Autophagy"]
N0 -->|"regulates"| N3
N4["LYSOSOME"]
N0 -->|"activates"| N4
N5["Als"]
N0 -->|"regulates"| N5
N6["Tumor"]
N0 -->|"activates"| N6
N7["Neurodegeneration"]
N0 -->|"causes"| N7
N8["TSC2"]
N0 -->|"activates"| N8
N9["Mtor"]
N0 -->|"regulates"| N9
N10["NEURODEGENERATION"]
N0 -->|"causes"| N10
N11["MTOR"]
N0 -->|"activates"| N11
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
class N1 gene
class N2 gene
class N3 pathway
class N4 gene
class N5 disease
class N6 disease
class N7 disease
class N8 gene
class N9 pathway
class N10 gene
class N11 gene| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TFEB Activation to Restore Lysosomal Biogenesis in Aged Syna | 0.591 | proteomics | Quantitative proteomics of the aging syn |
| Synergistic enhancement of autophagy and lysosomal biogenesi | 0.565 | neuroscience | Lysosomal dysfunction and cathepsin leak |
| TRPML1-PINK1/Parkin Axis Coordinates Mitophagy with Lysosoma | 0.560 | neurodegeneration | Does TRPML1 enhancement cause therapeuti |
| TFEB Activation to Restore Lysosomal Biogenesis in Alzheimer | 0.523 | proteomics | Quantitative proteomics of the aging syn |
| TFEB-Mediated Lysosomal Biogenesis Enhancement for NLRP3 Inf | 0.485 | Neuroinflammation | Immune atlas neuroinflammation analysis |
| TFEB Activation to Restore Lysosomal Biogenesis in Parkinson | 0.380 | proteomics | Quantitative proteomics of the aging syn |
Scientific analyses that reference this entity
proteomics | 2026-04-16 | 16 hypotheses Top: 0.591
neurodegeneration | 2026-04-01 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.50 · 2026-04-18
closed · Rounds: 5 · Score: 0.95 · 2026-04-01
Hypotheses and analyses mentioning lysosomal_biogenesis in their description or question text