gene

DNAJB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNAJB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

238Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

DNAJB1 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, regulates, activates. Associated with Aging, Als, Ataxia. Connected to 89 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	DNAJB1
Protein Type	Chaperone
Target Class	Chaperone
Function	DNAJB1 serves multiple essential cellular functions:
Mechanism of Action	Allosteric modulation of protein-protein interactions with Hsp70
Subcellular Localization	Cytosol: Predominant localization
Druggability	Low (0.35)
Clinical Stage	Phase I
Molecular Weight	38 kDa
Amino Acids	340 aa
Pathways	Chaperone, Complement, Lysosomal Degradation, Oxidative Stress
UniProt ID	M0QXK0
Ensembl ID	ENSG00000132002
GeneCards	DNAJB1
Human Protein Atlas	DNAJB1
Associated Diseases	Als, Alzheimer, Diabetes, Ms, neurodegeneration
Known Drugs/Compounds	115-7c, MAL3-101
Interactions	Alpha-Synuclein, ALPHA-SYNUCLEIN, ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOE4
SciDEX Target	View Target Profile (5 clinical trials)
KG Connections	238 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: DNAJB1 — AlphaFold M0QXK0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DNAJB1["DNAJB1"] -->|"protects against"| mutant_Huntingtin_aggregation["mutant Huntingtin aggregation"]
    DNAJB1["DNAJB1"] -->|"interacts"| mutant_Huntingtin["mutant Huntingtin"]
    DNAJB1["DNAJB1"] -->|"therapeutic target"| Autoimmune["Autoimmune"]
    DNAJB1["DNAJB1"] -->|"regulates"| Multiple_Sclerosis["Multiple Sclerosis"]
    DNAJB1["DNAJB1"] -->|"regulates"| Ms["Ms"]
    DNAJB1["DNAJB1"] -->|"regulates"| Als["Als"]
    h_637a53c9["h-637a53c9"] -->|"therapeutic target"| DNAJB1["DNAJB1"]
    h_637a53c9_1["h-637a53c9"] -->|"targets"| DNAJB1["DNAJB1"]
    STAT3["STAT3"] -->|"activates"| DNAJB1["DNAJB1"]
    HSPA1A["HSPA1A"] -->|"interacts"| DNAJB1["DNAJB1"]
    style DNAJB1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (165)

Target	Relation	Type	Str
Parkinson'S Disease	risk_factor_for	disease	0.85
HSP40	activates	gene	0.75
HSP70	activates	gene	0.75
mutant Huntingtin	interacts_with	protein	0.70
mutant Huntingtin aggregation	protects_against	process	0.70
Neuropathy	inhibits	disease	0.65
Diabetes	associated_with	disease	0.65
Spinocerebellar Ataxia	inhibits	disease	0.65
Ataxia	inhibits	disease	0.65
Alzheimer	stabilizes	disease	0.65
Neuropathy	stabilizes	disease	0.65
Huntington	stabilizes	disease	0.65
Parkinson	stabilizes	disease	0.65
Inflammation	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Huntington	regulates	disease	0.65
Ataxia	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Autoimmune	therapeutic_target	disease	0.65
Multiple Sclerosis	regulates	disease	0.65
Alzheimer	associated_with	disease	0.65
Aging	biomarker_for	disease	0.65
Ms	causes	disease	0.65
Als	associated_with	disease	0.65
Ms	regulates	disease	0.65
Als	regulates	disease	0.65
Ms	therapeutic_target	disease	0.65
Spinal Muscular Atrophy	inhibits	disease	0.65
Parkinson	inhibits	disease	0.65
ALS	activates	disease	0.65
Als	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Huntington	activates	disease	0.65
Aging	contributes_to	disease	0.65
HUNTINGTIN	causes	protein	0.65
Huntington	contributes_to	disease	0.65
Neurodegeneration	contributes_to	disease	0.65
Aging	activates	disease	0.65
Huntington	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Tumor	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Lymphoma	expressed_in	disease	0.65
HSPA1A	interacts_with	gene	0.61
HSP90AA1	interacts_with	gene	0.61
FKBP5	interacts_with	gene	0.61
neurodegeneration	associated_with	disease	0.61
Aβ	stabilizes	protein	0.60
DNAJA1	inhibits	gene	0.60

Incoming (73)

Source	Relation	Type	Str
h-637a53c9	targets_gene	hypothesis	0.90
h-637a53c9	targets	hypothesis	0.80
STAT3	activates	protein	0.80
HSPA1A	interacts_with	gene	0.61
HSP90AA1	interacts_with	gene	0.61
FKBP5	interacts_with	gene	0.61
SCA3	regulates	gene	0.60
HSPA4	regulates	gene	0.60
FOXP1	regulates	gene	0.60
HUNTINGTON	inhibits	gene	0.60
DNAJA2	therapeutic_target	gene	0.60
CD4	regulates	gene	0.60
HSPA1A	regulates	gene	0.60
HSP70	activates	gene	0.60
EGFR	activates	gene	0.60
DNAJA1	inhibits	gene	0.60
UBIQUITIN	contributes_to	gene	0.60
STAT3	contributes_to	gene	0.60
DIABETIC RETINOPATHY	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
HDAC6	expressed_in	gene	0.60
MAPK8	expressed_in	gene	0.60
TARDBP	expressed_in	gene	0.60
TSC2	biomarker_for	gene	0.60
UBIQUITIN	expressed_in	gene	0.60
BAG3	expressed_in	gene	0.60
UBC	expressed_in	gene	0.60
HSPD1	expressed_in	gene	0.60
DNAJC7	expressed_in	gene	0.60
HSPA6	expressed_in	gene	0.60
JAK2	activates	gene	0.60
HSP70	expressed_in	gene	0.60
HSPA1L	expressed_in	gene	0.60
DNAJC10	expressed_in	gene	0.60
HSPH1	expressed_in	gene	0.60
HSP90AB1	expressed_in	gene	0.60
IKBKB	expressed_in	gene	0.60
HSPE1	expressed_in	gene	0.60
HSPA1A	expressed_in	gene	0.60
HSP60	expressed_in	gene	0.60
DNAJB6	inhibits	gene	0.60
DNAJB2	inhibits	gene	0.60
HSPA1B	expressed_in	gene	0.60
NEURODEGENERATION	activates	gene	0.60
HUNTINGTON	activates	gene	0.60
PARKINSON	inhibits	gene	0.60
FERROPTOSIS	associated_with	gene	0.60
AGING	biomarker_for	gene	0.60
GENES	inhibits	gene	0.60
AND	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Can chaperone enhancement approaches overcome tau seed saturation effects in adv

protein folding | 2026-04-06 | 7 hypotheses Top: 0.740

APOE4 structural biology and therapeutic targeting strategies

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.795

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

While DNAJB1 enhancement showed promise, the debate raised concerns about whethe

closed · Rounds: 4 · Score: 0.73 · 2026-04-22

APOE4 differs from APOE3 by C112R causing domain interaction that alters lipid b

closed · Rounds: 4 · Score: 0.89 · 2026-04-06