gene

HSPA4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSPA4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

76Connections

0Hypotheses

0Analyses

50Outgoing

19Incoming

0Experiments

0Debates

Summary

HSPA4 is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, implicated in. Associated with Als, Cancer, Colorectal Cancer. Connected to 40 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	HSPA4
Full Name	Heat Shock Protein Family A (Hsp70) Member 4
Chromosome	1q22
Protein Type	Chaperone
Function	HSPA4 (also known as Hsp70L1 or Apg-2) is a constitutively expressed Hsp70 family member with multiple cellular functions
Primary Expression	Inducible by stress, constitutively expressed in some tissues
Pathways	NF-κB, MAPK
UniProt ID	Q9Y4X5
NCBI Gene ID	3309
GeneCards	HSPA4
Human Protein Atlas	HSPA4
Associated Diseases	neurodegeneration
Interactions	CDK1, EGFR, ERBB2, FOXO1, GENES, GNB4
KG Connections	76 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HSPA4 — AlphaFold Q9Y4X5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HSPA4 Gene

gene · 652 words

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Pathway Diagram

graph TD
    HSPA4["HSPA4"]
    Neurodegeneration{"Neurodegeneration"}
    HSPA4 -->|"regulates"| Neurodegeneration
    Multiple_Sclerosis{"Multiple Sclerosis"}
    HSPA4 -->|"regulates"| Multiple_Sclerosis
    Inflammation{"Inflammation"}
    HSPA4 -->|"regulates"| Inflammation
    Als{"Als"}
    HSPA4 -->|"regulates"| Als
    Neuroinflammation{"Neuroinflammation"}
    HSPA4 -->|"regulates"| Neuroinflammation
    Ms{"Ms"}
    HSPA4 -->|"regulates"| Ms
    FOXP1["FOXP1"]
    HSPA4 -->|"regulates"| FOXP1
    DNAJB1["DNAJB1"]
    HSPA4 -->|"regulates"| DNAJB1
    Oxidative_Stress(["Oxidative Stress"])
    HSPA4 -->|"regulates"| Oxidative_Stress
    Complement(["Complement"])
    HSPA4 -->|"regulates"| Complement
    neurodegeneration["neurodegeneration"]
    HSPA4 -->|"implicated in"| neurodegeneration
    PRKCD["PRKCD"]
    PRKCD -->|"associated with"| HSPA4
    style HSPA4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (57)

Target	Relation	Type	Str
Als	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Ms	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Melanoma	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Colorectal Cancer	regulates	disease	0.65
Cancer	regulates	disease	0.65
Als	activates	disease	0.65
Multiple Sclerosis	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Cancer	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
Mitophagy	expressed_in	pathway	0.60
Immune Response	expressed_in	pathway	0.60
YWHAZ	expressed_in	gene	0.60
Ferroptosis	expressed_in	pathway	0.60
TP53	expressed_in	gene	0.60
VDAC1	expressed_in	gene	0.60
ITGAM	expressed_in	gene	0.60
PPARG	expressed_in	gene	0.60
RELA	expressed_in	gene	0.60
SOD1	expressed_in	gene	0.60
NF-kB signaling	participates_in	pathway	0.60
PIK3R1	activates	gene	0.60
IGF1	activates	gene	0.60
CDK1	activates	gene	0.60
QSOX1	activates	gene	0.60
LAMB2	activates	gene	0.60
WNT4	activates	gene	0.60
LGALS1	activates	gene	0.60
JAK2	activates	gene	0.60
AKT	regulates	gene	0.60
GNB4	activates	gene	0.60
neuroinflammation	interacts_with	disease	0.60
Oxidative Stress	regulates	pathway	0.60
Complement	regulates	pathway	0.60
DIABETES MELLITUS	regulates	gene	0.60
GENES	activates	gene	0.60
ERBB2	activates	gene	0.60
AXON	regulates	gene	0.60
CANCER	regulates	gene	0.60
Wnt	activates	pathway	0.60
FOXP1	regulates	gene	0.60
Mapk	regulates	pathway	0.60
DNAJB1	regulates	gene	0.60
FOXO1	activates	gene	0.60
HSP90AA1	activates	gene	0.60
PRKACB	activates	gene	0.60
NFKBIA	expressed_in	gene	0.60

Incoming (19)

Source	Relation	Type	Str
PRKCD	associated_with	gene	0.80
CCND1	expressed_in	gene	0.60
HSP90B1	activates	gene	0.60
PI3K	regulates	gene	0.60
EGFR	activates	gene	0.60
YWHAZ	expressed_in	gene	0.60
HSP90AB1	expressed_in	gene	0.60
CAV1	expressed_in	gene	0.60
VDAC1	expressed_in	gene	0.60
PI3K	expressed_in	gene	0.60
SOD1	expressed_in	gene	0.60
RELA	expressed_in	gene	0.60
ITGAM	expressed_in	gene	0.60
PPARG	expressed_in	gene	0.60
TP53	expressed_in	gene	0.60
ANXA5	expressed_in	gene	0.60
AKT	expressed_in	gene	0.60
CYCS	expressed_in	gene	0.60
ENO1	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HSPA4 in their description or question text

No additional research found