gene

DNAJA2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNAJA2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6Connections

0Hypotheses

0Analyses

6Outgoing

0Incoming

0Experiments

0Debates

Summary

DNAJA2

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🧬 Gene Info

Gene Symbol	DNAJA2
Protein Type	Chaperone
Function	DNAJA2 (DnaJ Heat Shock Protein Family (Hsp40) Member A2) is a co-chaperone that stimulates the ATPase activity of Hsp70 proteins.
Primary Expression	various cancers
Ensembl ID	ENSG00000067715
GeneCards	DNAJA2
Human Protein Atlas	DNAJA2
J-domain protein (JDP)	Contains characteristic J-domain that activates Hsp70 ATPase
Substrate delivery	Binds misfolded proteins and delivers them to Hsp70
Protein folding	Assists Hsp70 in de novo protein folding
Protein refolding	Helps refold stress-denatured proteins
Protein degradation	Targets misfolded proteins for proteasomal or autophagic clearance
Transcription regulation	Associates with transcription factors
Associated Diseases	neurodegeneration
KG Connections	6 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DNAJA2

gene · 845 words

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Pathway Diagram

graph TD
    DNAJA2["DNAJA2"]
    Autoimmune{"Autoimmune"}
    DNAJA2 -->|"therapeutic target"| Autoimmune
    Multiple_Sclerosis{"Multiple Sclerosis"}
    DNAJA2 -->|"regulates"| Multiple_Sclerosis
    Ms{"Ms"}
    DNAJA2 -->|"regulates"| Ms
    Als{"Als"}
    DNAJA2 -->|"regulates"| Als
    CD4["CD4"]
    DNAJA2 -->|"regulates"| CD4
    DNAJB1["DNAJB1"]
    DNAJA2 -->|"therapeutic target"| DNAJB1
    neurodegeneration["neurodegeneration"]
    DNAJA2 -->|"implicated in"| neurodegeneration
    style DNAJA2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (6)

Target	Relation	Type	Str
Autoimmune	therapeutic_target	disease	0.65
Multiple Sclerosis	regulates	disease	0.65
Ms	regulates	disease	0.65
Als	regulates	disease	0.65
CD4	regulates	gene	0.60
DNAJB1	therapeutic_target	gene	0.60

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DNAJA2 in their description or question text

No additional research found