| Gene Symbol | DNAJB12 |
| Full Name | DnaJ Heat Shock Protein Family (Hsp40) Member B12 |
| Chromosome | 10q24.3 |
| Protein Type | Chaperone |
| Function | is a crucial co-chaperone protein that plays essential roles in protein quality control, ER-associated degradation (ERAD), and cellular proteostasis. |
| Subcellular Localization | DNAJB12 exhibits dual localization: |
| Molecular Weight | 36 kDa |
| Amino Acids | 324 aa |
| UniProt ID | Q9Y5W2 |
| Ensembl ID | ENSG00000135924 |
| GeneCards | DNAJB12 |
| Human Protein Atlas | DNAJB12 |
| Cytosolic form | Functions in cytosolic protein quality control, interacting with Hsc70/Hsp70-1A |
| ER-localized form | Partners with BiP (GRP78) in the ER for ERAD pathway function |
| J-domain-mediated activation | The J-domain stimulates ATP hydrolysis by Hsp70 partners, converting them to their high-affinity substrate-bound state |
| Associated Diseases | Amyotrophic Lateral Sclerosis, Parkinson's Disease, Huntington's Disease |
| KG Connections | 6 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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