protein

HSP40

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSP40: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

46Connections

1Hypotheses

0Analyses

29Outgoing

17Incoming

0Experiments

0Debates

Summary

Page for Hsp40 Protein

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	HSP40
Molecular Weight	80 kDa
Amino Acids	70 aa
Pathways	unfolded protein response, Chaperone
GeneCards	HSP40
Human Protein Atlas	HSP40
Associated Diseases	ALS, dementia, disease, frontotemporal, neurodegeneration, Neurodegenerative Diseases
Interactions	AMYLOID, APOE4, ATP, BAG1, DNAJA1, DNAJB1
KG Connections	46 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    HSP40("HSP40")
    AMYLOID["AMYLOID"]
    HSP40 -->|"inhibits"| AMYLOID
    Chaperone(["Chaperone"])
    HSP40 -->|"inhibits"| Chaperone
    HSP40 -->|"regulates"| Chaperone
    Proteostasis["Proteostasis"]
    HSP40 -->|"regulates"| Proteostasis
    Neurodegenerative_Diseases{"Neurodegenerative Diseases"}
    HSP40 -->|"associated_with"| Neurodegenerative_Diseases
    disease{"disease"}
    HSP40 -->|"associated_with"| disease
    HSP40 -->|"associated_with"| Chaperone
    Proteins("Proteins")
    HSP40 -->|"associated_with"| Proteins
    DNAJB6["DNAJB6"]
    DNAJB6 -->|"inhibits"| HSP40
    DNAJB6 -->|"interacts_with"| HSP40
    DNAJC5["DNAJC5"]
    DNAJC5 -->|"associated_with"| HSP40

Outgoing (29)

Target	Relation	Type	Str
HSP70	activates	gene	0.85
HSP70	associated_with	gene	0.65
HSPA1A	activates	gene	0.65
HSP70	interacts_with	gene	0.65
neurodegeneration	associated_with	disease	0.60
ALS	associated_with	disease	0.60
dementia	associated_with	disease	0.60
frontotemporal	associated_with	disease	0.60
HSPH1	activates	gene	0.55
HSPH1	interacts_with	gene	0.55
HSPA8	activates	gene	0.55
TDP-43	associated_with	gene	0.55
RNA	interacts_with	gene	0.55
TDP-43	interacts_with	gene	0.55
tauopathy	activates	disease	0.55
HSPA1B	activates	gene	0.55
TDP-43	activates	gene	0.55
unfolded protein response	participates_in	pathway	0.55
HSPA8	interacts_with	gene	0.55
HSPBP1	interacts_with	gene	0.55
HSPA1A	interacts_with	gene	0.55
AMYLOID	inhibits	gene	0.50
Chaperone	inhibits	pathway	0.50
Chaperone	regulates	pathway	0.50
Proteostasis	regulates	process	0.50
Neurodegenerative Diseases	associated_with	disease	0.50
disease	associated_with	disease	0.50
Chaperone	associated_with	pathway	0.50
Proteins	associated_with	protein	0.50

Incoming (17)

Source	Relation	Type	Str
DNAJB1	activates	gene	0.75
DNAJA1	activates	gene	0.65
ATP	interacts_with	gene	0.65
HSP110	regulates	gene	0.60
DNMT1	activates	gene	0.55
DNAJB6	associated_with	gene	0.55
BAG1	interacts_with	gene	0.55
HSP110	activates	gene	0.55
APOE4	activates	gene	0.55
HSP110	interacts_with	gene	0.55
DNAJB1	interacts_with	gene	0.55
HSC70	activates	gene	0.55
DNAJB6	inhibits	gene	0.50
DNAJB6	interacts_with	gene	0.50
CHIP	co_expressed_with	protein	0.50
HSC70	co_expressed_with	protein	0.50
DNAJC5	associated_with	gene	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
HSP70/HSP40 Chaperone Complex Secretion	0.380	neurodegeneration	Which specific factors in conditioned me

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HSP40 in their description or question text

No additional research found