gene

dnaja1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about dnaja1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

71Connections

0Hypotheses

0Analyses

50Outgoing

18Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	DNAJA1
Full Name	DnaJ Heat Shock Protein Family (Hsp40) Member A1
Chromosome	9p13.3
Protein Family	DnaJ/Hsp40 family
Protein Type	Chaperone
Function	is an important component in the neurobiology of neurodegenerative diseases.
UniProt ID	[P31689](https://www.uniprot.org/uniprot/P31689)
NCBI Gene ID	1652
Ensembl ID	ENSG00000116001
OMIM	601067
GeneCards	DNAJA1
Human Protein Atlas	DNAJA1
Client protein recognition	Identifies misfolded proteins
Hsp70 recruitment	Recruits Hsp70 (HSPA1A) to substrates
ATP hydrolysis stimulation	Enhances Hsp70 ATPase activity
Associated Diseases	neurodegeneration
Interactions	ATAXIN-3, DNAJB1, DNAJB2, DNAJB6, HUNTINGTON, Proteins
KG Connections	7 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DnaJ Heat Shock Protein Family (Hsp40) Member A1

gene · 740 words

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Pathway Diagram

graph TD
    DNAJA1["DNAJA1"]
    DNAJA1 -.biomarker for.-> Ms["Ms"]
    DNAJA1 -->|"inhibits"| Alzheimer["Alzheimer"]
    DNAJA1 -->|"inhibits"| Huntington["Huntington"]
    DNAJA1 -->|"inhibits"| Parkinson["Parkinson"]
    DNAJA1 -->|"inhibits"| Spinocerebellar_Ataxia["Spinocerebellar Ataxia"]
    DNAJA1 -->|"inhibits"| Ataxia["Ataxia"]
    DNAJA1 -->|"inhibits"| Neuropathy["Neuropathy"]
    ENO1["ENO1"] -.biomarker for.-> DNAJA1
    IREB2["IREB2"] -->|"interacts"| DNAJA1
    DNAJB6["DNAJB6"] -->|"inhibits"| DNAJA1
    HUNTINGTON["HUNTINGTON"] -->|"inhibits"| DNAJA1
    DNAJB1["DNAJB1"] -->|"inhibits"| DNAJA1
    ALZHEIMER["ALZHEIMER"] -->|"inhibits"| DNAJA1
    DNAJB2["DNAJB2"] -->|"inhibits"| DNAJA1
    PARKINSON["PARKINSON"] -->|"inhibits"| DNAJA1

Outgoing (53)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:DNAJA1	data_in	dataset_row	0.00
Huntington	inhibits	disease	0.65
Parkinson	inhibits	disease	0.65
Ms	biomarker_for	disease	0.65
HSP70	activates	gene	0.65
Alzheimer	inhibits	disease	0.65
Neuropathy	inhibits	disease	0.65
Spinocerebellar Ataxia	inhibits	disease	0.65
Ataxia	inhibits	disease	0.65
Huntington	stabilizes	disease	0.65
Neuropathy	stabilizes	disease	0.65
HSP40	activates	gene	0.65
Parkinson	stabilizes	disease	0.65
Alzheimer	stabilizes	disease	0.65
Spinal Muscular Atrophy	inhibits	disease	0.65
DNAJB2	stabilizes	gene	0.60
DNAJB6	stabilizes	gene	0.60
DNAJB1	inhibits	gene	0.60
DNAJB6	inhibits	gene	0.60
PARKINSON	inhibits	gene	0.60
Neuron	inhibits	cell_type	0.60
Fus	inhibits	protein	0.60
protein misfolding	inhibits	process	0.60
FERROPTOSIS	activates	gene	0.60
Ferroptosis	activates	pathway	0.60
GPX4	activates	gene	0.60
PARKINSON'S DISEASE	inhibits	gene	0.60
Huntington's disease	inhibits	disease	0.60
HSPA1A	activates	gene	0.60
FLT1	biomarker_for	gene	0.60
HSPA8	biomarker_for	gene	0.60
ATP1B1	interacts_with	gene	0.60
ATP1B3	interacts_with	gene	0.60
ABCB1	interacts_with	gene	0.60
PARKINSON	stabilizes	gene	0.60
Neuron	stabilizes	cell_type	0.60
Aβ	stabilizes	protein	0.60
HSP70	inhibits	gene	0.60
DNAJB2	inhibits	gene	0.60
tauopathy	activates	disease	0.55
HSP110	activates	gene	0.55
HSC70	activates	gene	0.55
DNAJB1	activates	gene	0.55
HSPA8	activates	gene	0.55
HSPH1	activates	gene	0.55
Neuron	expressed_in	cell_type	0.55
HUNTINGTON	inhibits	gene	0.50
DNAJB2	inhibits	gene	0.50
Proteins	inhibits	protein	0.50
Chaperone	inhibits	pathway	0.50

Incoming (18)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:DNAJA1	data_in	dataset_row	0.00
ALZHEIMER	stabilizes	gene	0.60
HUNTINGTON	stabilizes	gene	0.60
PARKINSON	inhibits	gene	0.60
HUNTINGTON'S DISEASE	inhibits	gene	0.60
NEURODEGENERATIVE DISEASES	inhibits	gene	0.60
AND	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
IREB2	interacts_with	gene	0.60
DNAJB2	inhibits	gene	0.60
ENO1	biomarker_for	gene	0.60
DNAJB1	stabilizes	gene	0.60
HSP70	stabilizes	gene	0.60
HUNTINGTON	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
DNAJB6	inhibits	gene	0.60
DNAJB1	inhibits	gene	0.60
HSP70	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning dnaja1 in their description or question text

No additional research found