protein

HUNTINGTIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HUNTINGTIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

815Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

HUNTINGTIN is a protein involved in neurodegeneration research. Key relationships include: associated with, contributes to, regulates. Associated with ALS, Aging, Als. Connected to 136 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	HUNTINGTIN
Full Name	Huntingtin (HTT)
Protein Type	Protein
Function	is a large protein encoded by the HTT gene, most famous for its role in Huntington's disease where CAG repeat expansion in the first exon leads to mutant huntingtin (mHTT).
Molecular Weight	350 kDa
Amino Acids	144 aa
Pathways	NF-κB
UniProt ID	Search UniProt
GeneCards	HUNTINGTIN
Human Protein Atlas	HUNTINGTIN
Normal range	10-35 glutamine residues
Reduced penetrance	36-39 glutamines
Associated Diseases	Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Ataxia
Known Drugs/Compounds	RAPAMYCIN
Interactions	Actin, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, amyotrophic lateral sclerosis
KG Connections	654 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: HUNTINGTIN — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Huntingtin (HTT)

protein · 3134 words

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Pathway Diagram

graph TD
    HUNTINGTIN["HUNTINGTIN"]
    HUNTINGTIN -->|"regulates"| BDNF["BDNF"]
    HUNTINGTIN -->|"regulates"| BDNF_synthesis["BDNF synthesis"]
    HUNTINGTIN -->|"regulates"| BDNF_transport["BDNF transport"]
    HUNTINGTIN -->|"causes"| Huntington_s_disease["Huntington's disease"]
    HUNTINGTIN -->|"expressed in"| cerebrospinal_fluid["cerebrospinal fluid"]
    HUNTINGTIN -->|"regulates"| Aging["Aging"]
    HUNTINGTIN -->|"regulates"| Alzheimer["Alzheimer"]
    HUNTINGTIN -->|"regulates"| Parkinson["Parkinson"]
    HUNTINGTIN -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    HUNTINGTIN -->|"regulates"| Stroke["Stroke"]
    HTT["HTT"] -->|"encodes"| HUNTINGTIN
    antisense_oligonucleotides["antisense oligonucleotides"] -->|"inhibits"| HUNTINGTIN
    NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"] -->|"regulates"| HUNTINGTIN
    BCL_2["BCL-2"] -->|"regulates"| HUNTINGTIN
    STROKE["STROKE"] -->|"regulates"| HUNTINGTIN
    MITOCHONDRIA["MITOCHONDRIA"] -->|"regulates"| HUNTINGTIN
    PRESENILIN_1["PRESENILIN-1"] -->|"regulates"| HUNTINGTIN
    PRESENILIN["PRESENILIN"] -->|"regulates"| HUNTINGTIN
    ALZHEIMER["ALZHEIMER"] -->|"regulates"| HUNTINGTIN
    EXERCISE["EXERCISE"] -->|"regulates"| HUNTINGTIN

Outgoing (495)

Target	Relation	Type	Str
BDNF	transports	gene	0.90
BDNF	regulates	protein	0.90
BDNF synthesis	regulates	pathway	0.90
BDNF transport	regulates	pathway	0.90
Tau Pathology	promotes	mechanism	0.85
DNA damage response	regulates	process	0.80
Huntington's disease	implicated_in	disease	0.80
polyglutamine	aggregates_with	compound	0.80
chromatin remodeling	regulates	process	0.80
RNA processing	regulates	process	0.80
AUTOPHAGY	inhibits	phenotype	0.70
AUTOPHAGY	treats	phenotype	0.70
cerebrospinal fluid	expressed_in	process	0.70
Huntington's disease	causes	disease	0.70
Huntington	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Multiple Sclerosis	contributes_to	disease	0.65
Ataxia	therapeutic_target	disease	0.65
Parkinson	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Ataxia	associated_with	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Huntington	expressed_in	disease	0.65
Inflammation	therapeutic_target	disease	0.65
ALS	inhibits	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Huntington	transports	disease	0.65
Neuroinflammation	contributes_to	disease	0.65
Als	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
Dementia	associated_with	disease	0.65
ALS	activates	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Spinocerebellar Ataxia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Spinal Muscular Atrophy	associated_with	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Inflammation	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Alzheimer	activates	disease	0.65
Ms	causes	disease	0.65
Huntington	activates	disease	0.65
Multiple Sclerosis	therapeutic_target	disease	0.65
Als	stabilizes	disease	0.65
Als	causes	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Aging	regulates	disease	0.65
Huntington	causes	disease	0.65

Incoming (320)

Source	Relation	Type	Str
TAU	interacts_with	protein	0.90
HTT	encodes	gene	0.70
antisense oligonucleotides	inhibits	drug	0.70
HUNTINGTON'S DISEASE	encodes	disease	0.65
HUNTINGTON'S DISEASE	targets	disease	0.65
KYNURENINE	interacts_with	phenotype	0.65
FUS	regulates	gene	0.65
DNAJB1	causes	gene	0.65
NEURONS	produces	cell_type	0.60
DNAJB6	interacts_with	gene	0.60
CDK4	inhibits	gene	0.60
JNK	inhibits	gene	0.60
HDAC4	inhibits	gene	0.60
CDK2	inhibits	gene	0.60
TDP-43	interacts_with	gene	0.60
AGING	therapeutic_target	gene	0.60
RAB7	associated_with	gene	0.60
ATG5	associated_with	gene	0.60
ENDOSOME	associated_with	gene	0.60
RNA	stabilizes	gene	0.60
DNA	interacts_with	gene	0.60
RNA	stabilizes	gene	0.60
MTORC1	associated_with	gene	0.60
NEURODEGENERATIVE DISORDERS	regulates	gene	0.60
MAP1LC3	associated_with	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
GSK3	contributes_to	gene	0.60
NEUROINFLAMMATION	therapeutic_target	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
APOPTOSIS	activates	gene	0.60
DNA	activates	gene	0.60
SYNAPSE	inhibits	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
GENES	inhibits	gene	0.60
NEUROTOXICITY	inhibits	gene	0.60
P21	inhibits	gene	0.60
NEURON	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
SMN1	associated_with	gene	0.60
ALS	associated_with	gene	0.60
HTT	associated_with	gene	0.60
DNMT1	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
ACTB	associated_with	gene	0.60
SETX	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
HUNTINGTIN	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
HUNTINGTIN	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HUNTINGTIN in their description or question text

No additional research found