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gene 1,299 words KG: DNAJB1
Contents

DNAJB1 Gene

🧬 Gene Info
Gene SymbolDNAJB1
Protein TypeChaperone
Target ClassChaperone
FunctionDNAJB1 serves multiple essential cellular functions:
Mechanism of ActionAllosteric modulation of protein-protein interactions with Hsp70
Subcellular Localization**Cytosol**: Predominant localization
DruggabilityLow (0.35)
Clinical StagePhase I
Molecular Weight38 kDa
Amino Acids340 aa
PathwaysChaperone, Complement, Lysosomal Degradation, Oxidative Stress
UniProt IDM0QXK0
Ensembl IDENSG00000132002
GeneCardsDNAJB1
Human Protein AtlasDNAJB1
Associated DiseasesAls, Alzheimer, Diabetes, Ms, neurodegeneration
Known Drugs/Compounds115-7c, MAL3-101
InteractionsAlpha-Synuclein, ALPHA-SYNUCLEIN, ALZHEIMER, ALZHEIMER'S DISEASE, APOE4, ASTROCYTE
SciDEX TargetView Target Profile (5 clinical trials)
KG Connections234 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (22)

Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72APOE Isoform Expression Across Glial Subtypes
Score: 0.74APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74CYP46A1 Overexpression Gene Therapy
Score: 0.73Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.72APOE Isoform Conversion Therapy
Score: 0.72Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69Cross-Seeding Prevention Strategy
Score: 0.69Glycine-Rich Domain Competitive Inhibition
Score: 0.64Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor
Score: 0.54Cryptic Exon Silencing Restoration
Score: 0.53Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51
pg 1/2Next →

Related Analyses (9)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedWhat are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completedLipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (3)

s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40s:** - Biochemical binding assays measuring PROTAC selectivi
falsification · proposed · Score: 0.40s:** - Single-cell RNA-seq to measure editing efficiency acr
falsification · proposed · Score: 0.40

See Also (15)

Swedish BioFINDER 2 Study: Biomarkers and Neurodegenera
clinical · Pages share 7 hypothesesDALY Methodology — Neurodegeneration
disease · Pages share 7 hypothesesExosomal Biomarkers in Neurodegeneration
biomarker · Pages share 7 hypothesesOlfactory Mucosa, Blood and Urine for Identification of
clinical · Pages share 7 hypothesesExosomal miR-155 in Neurodegeneration
biomarker · Pages share 7 hypotheses

Knowledge Graph (12 edges)

HSPA1A interacts_with DNAJB1
HSP90AA1 interacts_with DNAJB1
DNAJB1 associated_with neurodegeneration
DNAJB1 interacts_with HSPA1A
DNAJB1 interacts_with HSP90AA1
DNAJB1 interacts_with FKBP5
FKBP5 interacts_with DNAJB1
APOE co_discussed DNAJB1
DNAJB1 co_discussed ST6GAL1
DNAJB1 co_discussed FUT8

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