gene

HDAC2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HDAC2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

402Connections

2Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

3Debates

Summary

HDAC2 is a gene implicated in neurodegeneration research. Key relationships include: regulates, associated with, activates. Associated with Aging, Als, Alzheimer. Connected to 161 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	HDAC2
Full Name	Histone Deacetylase 2
Chromosome	6q21
Function	HDAC2 encodes histone deacetylase 2, a class I histone deacetylase that regulates gene expression through chromatin remodeling.
Primary Expression	neurons and plays critical roles in synaptic plasticity, memory formation, and transcriptional regulation
Pathways	Apoptosis, Dna Repair, Epigenetic, Hippo, Notch
UniProt ID	[Q92769](https://www.uniprot.org/uniprot/Q92769)
Ensembl ID	ENSG00000196591
OMIM	605185
GeneCards	HDAC2
Human Protein Atlas	HDAC2
Associated Diseases	Als, Alzheimer, Cancer, Colorectal Cancer, Gastric Cancer, Hepatocellular Carcinoma
Known Drugs/Compounds	SULFORAPHANE
Interactions	ACAT1, ACETYL-COA, Actin, Adiponectin, AKT, ALZHEIMER
SciDEX Hypotheses	HDAC2-Specific Repression of PU.1 Pioneer Factor T
KG Connections	402 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

HDAC2 Gene

gene · 790 words

→

HDAC2 Protein — Histone Deacetylase 2

protein · 1386 words

→

Pathway Diagram

graph TD
    HDAC2["HDAC2"]
    HDAC2 -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    HDAC2 -->|"regulates"| Parkinson["Parkinson"]
    HDAC2 -->|"regulates"| Alzheimer["Alzheimer"]
    HDAC2 -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    HDAC2 -->|"regulates"| Inflammation["Inflammation"]
    HDAC2 -->|"regulates"| Huntington["Huntington"]
    HDAC2 -->|"regulates"| Ms["Ms"]
    HDAC2 -.biomarker for.-> Als["Als"]
    HDAC2 -->|"activates"| Anxiety["Anxiety"]
    PLEKHG5["PLEKHG5"] -->|"interacts"| HDAC2
    SIRT6["SIRT6"] -->|"regulates"| HDAC2
    HDAC11["HDAC11"] -->|"expressed in"| HDAC2
    IKBKB["IKBKB"] -.biomarker for.-> HDAC2
    PIK3R1["PIK3R1"] -.biomarker for.-> HDAC2
    GENES["GENES"] -.biomarker for.-> HDAC2
    BDNF["BDNF"] -->|"regulates"| HDAC2
    HDAC3["HDAC3"] -->|"expressed in"| HDAC2
    SIRT5["SIRT5"] -->|"regulates"| HDAC2
    HDAC7["HDAC7"] -->|"expressed in"| HDAC2

Outgoing (236)

Target	Relation	Type	Str
LAPTM4B	associated_with	gene	0.98
Autophagy	regulates	process	0.95
LAPTM4B	binds	protein	0.93
Hepatocellular Carcinoma	associated_with	disease	0.92
Pro-Inflammatory Cytokines	regulates	protein	0.90
epigenetic regulation	participates_in	pathway	0.80
memory loss	causes	phenotype	0.80
Colorectal Cancer	associated_with	disease	0.75
Cancer	associated_with	disease	0.75
miR-34a	targets	gene	0.70
Epigenetic	regulates	pathway	0.70
Als	biomarker_for	disease	0.65
Alzheimer	biomarker_for	disease	0.65
TAU	inhibits	protein	0.65
Alzheimer	activates	disease	0.65
Anxiety	activates	disease	0.65
Ms	activates	disease	0.65
Depression	activates	disease	0.65
AUTOPHAGY	promotes	process	0.65
Inflammation	interacts_with	disease	0.65
Alzheimer	expressed_in	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Alzheimer	associated_with	disease	0.65
HDAC3	associated_with	gene	0.65
Carcinoma	therapeutic_target	disease	0.65
Cancer	expressed_in	disease	0.65
Als	inhibits	disease	0.65
Als	expressed_in	disease	0.65
Aging	inhibits	disease	0.65
Neurodegeneration	regulates	disease	0.65
Cardiac	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Autism	expressed_in	disease	0.65
Parkinson	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Huntington	regulates	disease	0.65
Ms	regulates	disease	0.65
NEURODEGENERATION	associated_with	concept	0.65
Leukemia	activates	disease	0.65
Ischemia	activates	disease	0.65
Als	activates	disease	0.65
Diabetes	activates	disease	0.65
ALS	expressed_in	disease	0.65
Carcinoma	activates	disease	0.65
Als	associated_with	disease	0.65
ALS	activates	disease	0.65
Gastric Cancer	associated_with	disease	0.65

Incoming (166)

Source	Relation	Type	Str
MIR34A	targets	gene	0.95
MIR34A	downregulates	gene	0.90
Creatine Phosphate	downregulates	compound	0.85
AKT	de-SUMOylates	gene	0.80
PLEKHG5	interacts_with	gene	0.80
CANCER	associated_with	gene	0.70
HDAC1	associated_with	gene	0.65
AKT	modifies	gene	0.65
SULFORAPHANE	inhibits	drug	0.65
SIRT1	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
ADNP	associated_with	gene	0.60
HDAC3	inhibits	gene	0.60
HDAC1	inhibits	gene	0.60
CBP	regulates	gene	0.60
GENES	biomarker_for	gene	0.60
LYSOSOME	activates	gene	0.60
AND	activates	gene	0.60
ARID1A	regulates	gene	0.60
ACVR2A	regulates	gene	0.60
MECP2	regulates	gene	0.60
MSH2	associated_with	gene	0.60
MSH3	regulates	gene	0.60
MLH1	associated_with	gene	0.60
MSH6	regulates	gene	0.60
ANGPT1	activates	gene	0.60
CAV1	activates	gene	0.60
BDNF	activates	gene	0.60
MAP2	activates	gene	0.60
SYNAPTOPHYSIN	activates	gene	0.60
MRE11	associated_with	gene	0.60
TRKB	activates	gene	0.60
IL6	interacts_with	gene	0.60
TET2	interacts_with	gene	0.60
BAX	regulates	gene	0.60
BRAF	associated_with	gene	0.60
TGFBR2	regulates	gene	0.60
CANCER	activates	gene	0.60
P53	therapeutic_target	gene	0.60
HDAC	causes	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
WNT	expressed_in	gene	0.60
RNA	activates	gene	0.60
APOPTOSIS	associated_with	gene	0.60
SIRT6	regulates	gene	0.60
HDAC11	expressed_in	gene	0.60
BDNF	regulates	gene	0.60
HDAC3	expressed_in	gene	0.60
SIRT5	regulates	gene	0.60
HDAC7	expressed_in	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
HDAC2 Phospho-Lock Window for Synaptic Gene Silencing	0.643	neurodegeneration	What is the optimal therapeutic window d
HDAC2-Specific Repression of PU.1 Pioneer Factor Target Site	0.415	neurodegeneration	How does HDAC1/2 deletion specifically e

Mentioning Analyses (2)

Scientific analyses that reference this entity

How does HDAC1/2 deletion specifically enhance microglial amyloid phagocytosis c

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.444

Neuroinflammation and microglial priming in early Alzheimer's Disease

neurodegeneration | 2026-04-04 | 14 hypotheses Top: 0.651

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity